Mechanism associated with changes in male reproductive functions during ageing process

Ajayi, Ayodeji Folorunsho; Onaolapo, Moyinoluwa Comfort; Omole, Ayomide Isaac; Adeyemi, Wale Johnson; Oluwole, David Tolulope

doi:10.1016/j.exger.2023.112232

Cited by 8 publications

(2 citation statements)

References 113 publications

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“…Ageing is a natural process during which human experience declines in their somatosensory systems [ 5 , 6 ], and a change in pain experience is one typical effect of ageing [ 7 , 8 ]. Somatosensory declines tend to make individuals more susceptible to injury [ 2 ], suggesting age-related decreases in pain sensitivity [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Age-associated changes in multimodal pain perception

Zhi,

Zhang,

Zhang

et al. 2024

Age and Ageing

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Background Pain sensitivity varies across multimodal somatosensory stimuli that can rely on different conductive fibres, which, when damaged, will lead to neuropathies. However, there is limited research examining the characteristics of perceived pain, particularly as affected by the ageing process, as induced by various somatosensory stimuli that may rely on small or large fibres. Methods Using heat and pressure stimuli on small and large fibres separately on both younger and older adults, this study examined age-associated changes in pain perception by measuring self-reported pain sensitivity, pain threshold and pain discriminability. Results Heat pain threshold was significantly positively correlated with age, but not pressure pain threshold. Pain threshold increased and pain discriminability decreased in response to heat stimuli in the older participants compared with the younger ones. Conclusion An age-associated decline in heat pain perception was observed, suggesting an earlier degradation of heat perception. These findings provide new insight into understanding and assessing somatosensory disorders, which can help ageing populations better maintain healthy sensory functioning.

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Section: Introductionmentioning

confidence: 99%

Age-associated changes in multimodal pain perception

Zhi,

Zhang,

Zhang

et al. 2024

Age and Ageing

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“…Under physiological conditions, ROS are converted by the action of the antioxidant enzyme SOD into hydrogen peroxide, which is metabolized by CAT and GPX into water and oxygen, thus lowering intracellular stress [16]. The imbalance of these antioxidant defense mechanisms is correlated with an impairment of ejaculate quality, with testicular morphological changes leading to male infertility [17].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress Biomarkers in Male Infertility: Established Methodologies and Future Perspectives

Mottola,

Palmieri,

Carannante

et al. 2024

Genes

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Male fertility can be affected by oxidative stress (OS), which occurs when an imbalance between the production of reactive oxygen species (ROS) and the body’s ability to neutralize them arises. OS can damage cells and influence sperm production. High levels of lipid peroxidation have been linked to reduced sperm motility and decreased fertilization ability. This literature review discusses the most commonly used biomarkers to measure sperm damage caused by ROS, such as the high level of OS in seminal plasma as an indicator of imbalance in antioxidant activity. The investigated biomarkers include 8-hydroxy-2-deoxyguanosine acid (8-OHdG), a marker of DNA damage caused by ROS, and F2 isoprostanoids (8-isoprostanes) produced by lipid peroxidation. Furthermore, this review focuses on recent methodologies including the NGS polymorphisms and differentially expressed gene (DEG) analysis, as well as the epigenetic mechanisms linked to ROS during spermatogenesis along with new methodologies developed to evaluate OS biomarkers. Finally, this review addresses a valuable insight into the mechanisms of male infertility provided by these advances and how they have led to new treatment possibilities. Overall, the use of biomarkers to evaluate OS in male infertility has supplied innovative diagnostic and therapeutic approaches, enhancing our understanding of male infertility mechanisms.

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