Mechanism and Suppression of Physisorbed-Water-Caused Hysteresis in Graphene FET Sensors

Bartošík, Miroslav; Mach, Jindřich; Piastek, Jakub; Nezval, David; Konečný, Martin; Švarc, Vojtěch; Ensslin, Klaus; Šikola, Tomáš

doi:10.1021/acssensors.0c01441

Cited by 17 publications

(13 citation statements)

References 44 publications

(65 reference statements)

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“…The possible reason of the V Dirac shift is due to the interaction between the device and the ions in PBS solution, and the Dirac point shifts of the GO/Gr FET and Gr FET are comparable with the previous reports and acceptable in real applications [ 53 ]. To further confirm the stability of the GO/Gr and Gr FETs, we performed the hysteresis test since the Gr FET normally exhibits hysteresis due to water absorption on the channel surface when it works as biosensors [ 54 ]. As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Graphene oxide-graphene Van der Waals heterostructure transistor biosensor for SARS-CoV-2 protein detection

Gao

Chu

Han

et al. 2022

Talanta

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The current outbreaking of the coronavirus SARS-CoV-2 pandemic threatens global health and has caused serious concern. Currently there is no specific drug against SARS-CoV-2, therefore, a fast and accurate diagnosis method is an urgent need for the diagnosis, timely treatment and infection control of COVID-19 pandemic. In this work, we developed a field effect transistor (FET) biosensor based on graphene oxide-graphene (GO/Gr) van der Waals heterostructure for selective and ultrasensitive SARS-CoV-2 proteins detection. The GO/Gr van der Waals heterostructure was in-situ formed in the microfluidic channel through π-π stacking. The developed biosensor is capable of SARS-CoV-2 proteins detection within 20 min in the large dynamic range from 10 fg/mL to 100 pg/mL with the limit of detection of as low as ∼8 fg/mL, which shows ∼3 × sensitivity enhancement compared with Gr-FET biosensor. The performance enhancement mechanism was studied based on the transistor-based biosensing theory and experimental results, which is mainly attributed to the enhanced SARS-CoV-2 capture antibody immobilization density due to the introduction of the GO layer on the graphene surface. The spiked SARS-CoV-2 protein samples in throat swab buffer solution were tested to confirm the practical application of the biosensor for SARS-CoV-2 proteins detection. The results indicated that the developed GO/Gr van der Waals heterostructure FET biosensor has strong selectivity and high sensitivity, providing a potential method for SARS-CoV-2 fast and accurate detection.

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Section: Resultsmentioning

confidence: 99%

Graphene oxide-graphene Van der Waals heterostructure transistor biosensor for SARS-CoV-2 protein detection

Gao

Chu

Han

et al. 2022

Talanta

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“…This can cause uncertainty in evaluating the doping level of graphene and the subsequent amount of detected molecules. 51 , 52 To test the stability of Gr-FET devices, we monitored the channel resistance of our samples every week (in air) under ambient lab conditions (humidity < 30%). As shown in Figure 4 f, a very small change in resistance was observed over a period of 6 weeks which demonstrates the stability of our devices.…”

Section: Results and Discussionmentioning

confidence: 99%

Graphene-Based Field-Effect Transistor for Ultrasensitive Immunosensing of SARS-CoV-2 Spike S1 Antigen

Shahdeo

Chauhan

Majumdar

et al. 2022

ACS Appl. Bio Mater.

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Coronavirus disease (COVID-19) is an infectious disease that has posed a global health challenge caused by the SARS-CoV-2 virus. Early management and diagnosis of SARS-CoV-2 are crucial for the timely treatment, traceability, and reduction of viral spread. We have developed a rapid method using a Graphene-based Field-Effect Transistor (Gr-FET) for the ultrasensitive detection of SARS-CoV-2 Spike S1 antigen (S1-Ag). The in-house developed antispike S1 antibody (S1-Ab) was covalently immobilized on the surface of a carboxy functionalized graphene channel using carbodiimide chemistry. Ultraviolet–visible spectroscopy, Fourier-Transform Infrared Spectroscopy, X-ray Photoelectron Spectroscopy (XPS), Atomic Force Microscopy (AFM), Optical Microscopy, Raman Spectroscopy, Scanning Electron Microscopy (SEM), Enzyme-Linked Immunosorbent Assays (ELISA), and device stability studies were conducted to characterize the bioconjugation and fabrication process of Gr-FET. In addition, the electrical response of the device was evaluated by monitoring the change in resistance caused by Ag–Ab interaction in real time. For S1-Ag, our Gr-FET devices were tested in the range of 1 fM to 1 μM with a limit of detection of 10 fM in the standard buffer. The fabricated devices are highly sensitive, specific, and capable of detecting low levels of S1-Ag.

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“…Bartošík et al found that the p-doping of graphene FET sensors is caused by the capture of graphene due to the chemical adsorption of water on the graphene–SiO 2 interface [ 37 ]. As shown in Figure 3 a, when water molecules are physically adsorbed on the graphene surface at higher relative humidity (RH%), the water molecules are captured by graphene due to chemical adsorption on the graphene–SiO 2 interface.…”

Section: Sensing Principlementioning

confidence: 99%

“… ( a ) Schematic diagram of the initial state of a graphene FET after physical interaction of electrons with water; ( b ) electrons change immediately after the gate voltage is applied; ( c , d ) schematic diagram of the state when a more extended grid voltage is applied ( c ) at lower and ( d ) at higher relative humidity [ 37 ]. Copyright (2020), used with permission from Elsevier.…”

Section: Figurementioning

confidence: 99%

Research Progress of Graphene and Its Derivatives towards Exhaled Breath Analysis

Yang

Tian

et al. 2022

Biosensors

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The metabolic process of the human body produces a large number of gaseous biomarkers. The tracking and monitoring of certain diseases can be achieved through the detection of these markers. Due to the superior specific surface area, large functional groups, good optical transparency, conductivity and interlayer spacing, graphene, and its derivatives are widely used in gas sensing. Herein, the development of graphene and its derivatives in gas-phase biomarker detection was reviewed in terms of the detection principle and the latest detection methods and applications in several common gases, etc. Finally, we summarized the commonly used materials, preparation methods, response mechanisms for NO, NH3, H2S, and volatile organic gas VOCs, and other gas detection, and proposed the challenges and prospective applications in this field.

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Mechanism and Suppression of Physisorbed-Water-Caused Hysteresis in Graphene FET Sensors

Cited by 17 publications

References 44 publications

Graphene oxide-graphene Van der Waals heterostructure transistor biosensor for SARS-CoV-2 protein detection

Graphene oxide-graphene Van der Waals heterostructure transistor biosensor for SARS-CoV-2 protein detection

Graphene-Based Field-Effect Transistor for Ultrasensitive Immunosensing of SARS-CoV-2 Spike S1 Antigen

Research Progress of Graphene and Its Derivatives towards Exhaled Breath Analysis

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