Mechanism and regulation of cargo entry into the Commander recycling pathway
Rebeka Butkovič,
Alexander P. Walker,
Michael D. Healy
et al.
Abstract:Commander is a multiprotein complex that orchestrates endosomal recycling of diverse integral cargo proteins and in humans is required for normal skeletal, brain, kidney, and cardiovascular development. While the structure of this complex has recently been described, the central question of how cargo proteins are selected for entry into the Commander recycling pathway remains unclear. Here using recombinant protein reconstitution andin silicopredictions we identify the evolutionary conserved mechanism through … Show more
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