Mechanism and rational combinations with GP‐2250, a novel oxathiazine derivative, in ovarian cancer
Mark S. Kim,
Deanna Glassman,
Katelyn F. Handley
et al.
Abstract:BackgroundGP‐2250, a novel analog of taurultam (TRLT), has emerged as a potent anti‐neoplastic drug; however, the mechanisms underlying its effects are not well understood. Here, we investigated the mechanism of action and the biological effects of GP‐2250 using in vitro and in vivo models.MethodsWe carried out a series of in vitro (MTT assay, Annexin V/PI assay, colony formation assay, reverse‐phase protein array [RPPA], and HRLC/IC analysis) to determine the biological activity of GP‐2250 and investigate the… Show more
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