Mechanism and physical activities in bone-skeletal muscle crosstalk

Zhao, Zhonghan; Yan, Kai; Guan, Qiao; Guo, Qiang; Zhao, Can

doi:10.3389/fendo.2023.1287972

Cited by 2 publications

(1 citation statement)

References 83 publications

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“…The exact mechanisms behind this process are not yet fully understood, but it appears that IGF-1 plays a fundamental role. RT can lead to an increase in IGF-1 secretion by skeletal muscle, which in turn promotes the hypertrophy of muscle fibers, enhances muscle strength, and prevents muscle loss [221][222][223]. According to recent studies, patients with Crohn's disease who practiced RT showed significant improvements in muscle strength, muscle function, and bone mineral density [224,225].…”

Section: Resistance Trainingmentioning

confidence: 99%

Navigating the Intersection: Sarcopenia and Sarcopenic Obesity in Inflammatory Bowel Disease

Calvez,

Becherucci,

Covello

et al. 2024

Biomedicines

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Inflammatory bowel diseases (IBDs) are intricate systemic conditions that can extend beyond the gastrointestinal tract through both direct and indirect mechanisms. Sarcopenia, characterized by a reduction in muscle mass and strength, often emerges as a consequence of the clinical course of IBDs. Indeed, sarcopenia exhibits a high prevalence in Crohn’s disease (52%) and ulcerative colitis (37%). While computed tomography and magnetic resonance imaging remain gold-standard methods for assessing muscle mass, ultrasound is gaining traction as a reliable, cost-effective, and widely available diagnostic method. Muscle strength serves as a key indicator of muscle function, with grip strength test emerging nowadays as the most reliable assessment method. In IBDs, sarcopenia may arise from factors such as inflammation, malnutrition, and gut dysbiosis, leading to the formulation of the ‘gut–muscle axis’ hypothesis. This condition determines an increased need for surgery with poorer post-surgical outcomes and a reduced response to biological treatments. Sarcopenia and its consequences lead to reduced quality of life (QoL), in addition to the already impaired QoL. Of emerging concern is sarcopenic obesity in IBDs, a challenging condition whose pathogenesis and management are still poorly understood. Resistance exercise and nutritional interventions, particularly those aimed at augmenting protein intake, have demonstrated efficacy in addressing sarcopenia in IBDs. Furthermore, anti-TNF biological therapies showed interesting outcomes in managing this condition. This review seeks to furnish a comprehensive overview of sarcopenia in IBDs, elucidating diagnostic methodologies, pathophysiological mechanisms, and clinical implications and management. Attention will also be paid to sarcopenic obesity, exploring the pathophysiology and possible treatment modalities of this condition.

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Section: Resistance Trainingmentioning

confidence: 99%

Navigating the Intersection: Sarcopenia and Sarcopenic Obesity in Inflammatory Bowel Disease

Calvez,

Becherucci,

Covello

et al. 2024

Biomedicines

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From Plant to Patient: The Metabolic Benefits of Phytoestrogens

Kumar Verma,

Kumar Singh,

Tripathi

2024

Herbs and Spices - New Perspectives in Human Health and Food Industry [Working Title]

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In recent years, there has been a growing interest in the potential health benefits of phytoestrogens, a diverse group of naturally occurring compounds found in plants. These compounds, with structural similarities to estrogen, are found in foods such as soybeans, flaxseeds and sesame seeds, and are studied for their roles in modulating hormonal activity and antioxidant properties. Their estrogen-like functions make them particularly interesting in managing conditions exacerbated by hormonal imbalances, such as type 2 diabetes, obesity, cardiovascular diseases, and osteoporosis. Phytoestrogens enhance insulin sensitivity and glucose metabolism, while their anti-oxidant properties neutralize free radicals and inhibit lipid peroxidation. They also influence fat metabolism and reduce adipogenesis, addressing oxidative stress and inflammation. Their estrogenic effects improve bone mineral density and reduce fracture risks, particularly in postmenopausal women, highlighting their broad potential in metabolic disease management. This growing body of research suggests that phytoestrogens, due to their unique properties and diverse mechanisms of action, could be a valuable addition to dietary and therapeutic strategies in the prevention and management of various metabolic diseases. This chapter delves into the multifaceted roles of phytoestrogens in metabolic disorders, with a special focus on their antioxidant properties.

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Mechanism and physical activities in bone-skeletal muscle crosstalk

Cited by 2 publications

References 83 publications

Navigating the Intersection: Sarcopenia and Sarcopenic Obesity in Inflammatory Bowel Disease

Navigating the Intersection: Sarcopenia and Sarcopenic Obesity in Inflammatory Bowel Disease

From Plant to Patient: The Metabolic Benefits of Phytoestrogens

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