Mechanism and Extensibility of the Reaction

Applications of CeCl3 as an Environmental Friendly Promoter in Organic Chemistry

“…For this reason, this type of reaction has not yet found general synthetic applications, especially for the extreme reaction conditions required . Even though organocerium reagents are reactive toward acidic hydrogen, some reaction conditions have been reported allowing an efficient cross-coupling between various RLi/CeCl 3 complexes and a range of allyl, homoallyl, and propargyl alcohols . The combination of both organollithium compounds and lithium hydride with dry CeCl 3 works very well (Scheme ), and products are obtained in moderate to good yields and without chromatographic purification of the crude product.…”