Mechanics of Fresh, Refrigerated, and Frozen Arterial Tissue

Stemper, Brian D.; Yoganandan, Narayan; Stineman, Michael R.; Gennarelli, Thomas A.; Baisden, Jamie; Pintar, Frank A.

doi:10.1016/j.jss.2006.09.001

Cited by 154 publications

(114 citation statements)

References 61 publications

(44 reference statements)

Supporting

Mentioning

102

Contrasting

Order By: Relevance

“…This suggested that the proposed protocol did not modify the ultimate strain of the blood vessels under the conditions employed herein. A similar result has been previously reported investigating the mechanics of arterial tissue stored in several conditions, showing that the ultimate strain of the treated samples did not differ from the control case (41).…”

Section: Discussionsupporting

confidence: 89%

Decellularized bovine reinforced vessels for small-diameter tissue-engineered vascular grafts

Grandi

Baiguera²,

Martorina³

et al. 2011

Int J Mol Med

View full text Add to dashboard Cite

Abstract. The aim of the present study was to investigate the influence of a decellularization protocol on the structure and the mechanical behavior of small-diameter (<6 mm) tibial calf arteries and veins. Calf vessels were decellularized by a detergent-enzymatic method (DEM), partially hydrolyzed with trypsin and subsequently cross-linked using poly(ethylene glycol) diglycidyl ether. Our results showed that i) the DEM can be considered a simple and valuable procedure for the preparation of complete acellular arteries and veins able to preserve a high degree of collagen and elastic fibers, and ii) poly(ethylene glycol) diglycidyl ether cross-linking treatment provides appropriate mechanical reinforcement of blood vessels. Histologically, the decellularized vessels were obtained employing the detergent-enzymatic procedure and their native extracellular matrix histoarchitecture and components remained well preserved. Moreover, the decellularization protocol can be considered an effective method to remove HLA class I antigen expression from small-diameter tibial calf arteries and veins. Cytocompatibility of decellularized cross-linked vessels was evaluated by endothelial and smooth muscle cell seeding on luminal and adventitial vessel surfaces, respectively.

show abstract

Section: Discussionsupporting

confidence: 89%

Decellularized bovine reinforced vessels for small-diameter tissue-engineered vascular grafts

Grandi

Baiguera²,

Martorina³

et al. 2011

Int J Mol Med

View full text Add to dashboard Cite

show abstract

“…The magnitude of the stress in the control samples is higher here than reported in other publications [44]. However, a possible explanation is that preconditioning was performed up to 15 mm and samples were extended further than this when stretched to failure.…”

Section: Mechanical Tests and Effects Of Digestioncontrasting

confidence: 55%

Creating a model of diseased artery damage and failure from healthy porcine aorta

Noble

Smulders

Green

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

View full text Add to dashboard Cite

Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/) eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request.Creating a model of diseased artery damage and failure from healthy porcine aorta AbstractLarge quantities of diseased tissue are required in the research and development of new generations of medical devices, for example for use in physical testing. However, these are difficult to obtain. In contrast, porcine arteries are readily available as they are regarded as waste. Therefore, reliable means of creating from porcine tissue physical models of diseased human tissue that emulate well the associated mechanical changes would be valuable. To this end, we studied the effect on mechanical response of treating porcine thoracic aorta with collagenase, elastase and glutaraldehyde. The alterations in mechanical and failure properties were assessed via uniaxial tension testing. A constitutive model composed of the Gasser-Ogden-Holzapfel model, for elastic response, and a continuum damage model, for the failure, was also employed to provide a further basis for comparison [1,2]. For the concentrations used here it was found that: collagenase treated samples showed decreased fracture stress in the axial direction only; elastase treated samples showed increased fracture stress in the circumferential direction only; and glutaraldehyde samples showed no change in either direction. With respect to the proposed constitutive model, both collagenase and elastase had a strong effect on the fibre-related terms. The model more closely captured the tissue response in the circumferential direction, due to the smoother and sharper transition from damage initiation to complete failure in this direction. Finally, comparison of the results with those of tensile tests on diseased tissues suggests these treatments indeed provide a basis for creation of physical models of diseased arteries.

show abstract

“…Plaque samples were endarterectomised in toto with preservation of plaque structural integrity when cutting along the longitudinal length of the specimen. Samples were taken from the hospital and frozen in phosphate buffer solution (Fisher Scientific, Product code: 12821680) at -20°C as this method of storage has been shown to have no significant effects on arterial tissue mechanical properties [50][51][52].…”

Section: Patient Characteristicsmentioning

confidence: 99%

The influence of composition and location on the toughness of human atherosclerotic femoral plaque tissue

et al. 2016

View full text Add to dashboard Cite

The toughness of femoral atherosclerotic tissue is of pivotal importance to understanding the mechanism of luminal expansion during cutting balloon angioplasty (CBA) in the peripheral vessels. Furthermore, the ability to relate this parameter to plaque composition, pathological inclusions and location within the femoral vessels would allow for the improvement of existing CBA technology and for the stratification of patient treatment based on the predicted fracture response of the plaque tissue to CBA. Such information may lead to a reduction in clinically observed complications, an improvement in trial results and an increased adoption of the CBA technique to reduce vessel trauma and further endovascular treatment uptake.This study characterises the toughness of atherosclerotic plaque extracted from the femoral arteries of ten patients using a lubricated guillotine cutting test to determine the critical energy release rate. This information is related to the location that the plaque section was removed from within the femoral vessels and the composition of the plaque tissue,

show abstract

Mechanics of Fresh, Refrigerated, and Frozen Arterial Tissue

Cited by 154 publications

References 61 publications

Decellularized bovine reinforced vessels for small-diameter tissue-engineered vascular grafts

Decellularized bovine reinforced vessels for small-diameter tissue-engineered vascular grafts

Creating a model of diseased artery damage and failure from healthy porcine aorta

The influence of composition and location on the toughness of human atherosclerotic femoral plaque tissue

Contact Info

Product

Resources

About