Mechanics of collagen–hydroxyapatite model nanocomposites

Libonati, Flavia; Nair, Arun K.; Vergani, L.; Buehler, Markus J.

doi:10.1016/j.mechrescom.2013.08.008

Cited by 43 publications

(38 citation statements)

References 34 publications

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“…Hydroxyapatite and collagen represent the basic building blocks of bone that are arranged at various lengthscales to form a complex hierarchical structure [3,4]. Hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 ] exhibits excellent biocompatibility, bioactivity, strong plasticity, outstanding mechanical properties and osteoconductivity in vivo.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Hydroxyapatite/Collagen (HA/COL) Composite Powder Using a Novel Precipitation Technique

Yoruç

Aydınoğlu

2015

Acta Phys. Pol. A

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A new biomimetic precipitation technique was developed to synthesize hydroxyapatite/collagen nanocomposites. The componential and morphological properties of nano-composites were investigated. It was revealed that the inorganic phase in the nano-composite was carbonate-substituted hydroxyapatite with low crystallinity. Indeed both characteristic peaks for HA and Col molecule and shifts of the characteristic peaks have indicated on HA-Col bonding. Morphology studies showed that hydroxyapatite particles with the average size of 50 nm were distributed homogeneously in the polymer matrix. According to the TEM micrographs, inorganic particles were needle-like and had regular crystallographic orientation. These results suggest that the hydroxyapatite/collagen nano-composites are promising biomaterials for bone tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Hydroxyapatite/Collagen (HA/COL) Composite Powder Using a Novel Precipitation Technique

Yoruç

Aydınoğlu

2015

Acta Phys. Pol. A

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“…Recently, Fathima et al showed that the extent of cross linking in collagen samples modified by different chemical agents alter significantly the dynamics of bound water on the NMR time scale 57 . Libonati et al 58 performed molecular dynamic simulations in a collagen-hydroxyapatite nanocomposite (in both dry and wet cases). Their work showed that the hydrogen bonds between collagen and hydroxyapatite play an important role in fracture resistance.…”

Section: Resultsmentioning

confidence: 99%

Behavior of Water in Collagen and Hydroxyapatite Sites of Cortical Bone: Fracture, Mechanical Wear, and Load Bearing Studies

et al. 2015

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The mechanical properties of cortical bone, which is largely comprised of collagen, hydroxyapatite, and water, are known to hinge on hydration. Recently, the characteristics of water in bone have drawn attention as potential markers of bone quality. We report on the dynamics, diffusion, population, and exchange of water in cortical bone by NMR relaxation and diffusion methodologies. Relaxation measurements over timescales ranging from 0.001 to 4.2 s reveal two distinguishable water environments. Systematic exposure to ethylenediaminetetraacetic acid or collagenase reveals one peak in our 2D relaxation map belonging to water present in the hydroxyapatite rich environment, and a second peak with shorter relaxation times arising from a collagen rich site. Diffusion-T2 measurements allowed for direct measurement of the diffusion coefficient of water in all observable reservoirs. Further, deuterium relaxation methods were applied to study cortical bone under an applied force, following mechanical wear or fracture. The tumbling correlation times of water reduce in all three cases, indicating that water dynamics may be used as a probe of bone quality. Lastly, changes in the relative populations and correlation times of water in bone under an applied force suggest that load bearing occurs largely in the collagen rich environment and is reversible.

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“…The Ca + in the HA likely forms hydrogen bonds with the CONH and OH groups in the collagen. These bonds probably form with the proline and lysine in the collagen …”

Section: Discussionmentioning

confidence: 99%

Synthesis and characterization of a novel scaffold for bone tissue engineering based on Wharton's jelly

Martinez

Fernández

Prado

et al. 2017

J Biomedical Materials Res

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A composite is a material made of more than one component, and the bond between the components is on a scale larger than the atomic scale. The objective of the present study was to synthesize and perform the structural characterization and biological evaluation of a new biocomposite (BCO) based on a novel combination of an organic and an inorganic phase, for bone tissue engineering applications. The organic phase consisted of Wharton's jelly (WJ), which was obtained from embryonic tissue following a protocol developed by our laboratory. The inorganic phase consisted of bioceramic particles (BC), produced by sintering hydroxyapatite (HA) with β- tricalcium phosphate (β-TCP), and bioactive glass particles (BG). Each phase of the BCO was fully characterized by SEM, EDS, XRD, and FTIR. Biocompatibility was evaluated in vivo in the tibiae of Wistar rats (n = 40). Histological evaluation was performed at 0, 1, 7, 14, 30, and 60 days. XRD showed the phases corresponding to HA and β-TCP, whereas diffractogram of BG showed it to have an amorphous structure. EDS showed mainly Si and Na, Ca, P in BG, and Ca and P in HA and β-TCP. FTIR identified bonds between the organic and inorganic phases. From a mechanical viewpoint, the composite showed high flexural strength of 40.3 ± 0.8 MPa. The synthesized BCO exhibited adequate biocompatibility as shown by formation of lamellar type bone linked by BG and BC particles. The biomaterial presented here showed excellent mechanical and biocompatibility properties for its potential clinical use. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1034-1045, 2017.

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Mechanics of collagen–hydroxyapatite model nanocomposites

Cited by 43 publications

References 34 publications

Synthesis of Hydroxyapatite/Collagen (HA/COL) Composite Powder Using a Novel Precipitation Technique

Synthesis of Hydroxyapatite/Collagen (HA/COL) Composite Powder Using a Novel Precipitation Technique

Behavior of Water in Collagen and Hydroxyapatite Sites of Cortical Bone: Fracture, Mechanical Wear, and Load Bearing Studies

Synthesis and characterization of a novel scaffold for bone tissue engineering based on Wharton's jelly

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