Mechanics of arterial subfailure with increasing loading rate

Stemper, Brian D.; Yoganandan, Narayan; Pintar, Frank A.

doi:10.1016/j.jbiomech.2006.07.005

Cited by 32 publications

(22 citation statements)

References 42 publications

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“…The poorer quality of the curve fits in the axial direction can be partially attributed to the fragmented and discontinuous curve profile, which is likely because of pulling against the main fibre orientation [45]. Similar effects have been observed in other failure tests such as peel testing [59].…”

Section: Parameter Fitting and Effects Of Digestion 421 Quality Ansupporting

confidence: 64%

“…However, a possible explanation is that preconditioning was performed up to 15 mm and samples were extended further than this when stretched to failure. Thus the region between 15 mm displacement and failure will show greater time-dependent behaviour and it has been previously shown that loading rate affects the failure stress and stretch [45,46,47]. Nevertheless, all tests were performed under the same conditions and as such all comparisons between treatment types remain valid.…”

Section: Mechanical Tests and Effects Of Digestionmentioning

confidence: 99%

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Creating a model of diseased artery damage and failure from healthy porcine aorta

Noble

Smulders

Green

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/) eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request.Creating a model of diseased artery damage and failure from healthy porcine aorta AbstractLarge quantities of diseased tissue are required in the research and development of new generations of medical devices, for example for use in physical testing. However, these are difficult to obtain. In contrast, porcine arteries are readily available as they are regarded as waste. Therefore, reliable means of creating from porcine tissue physical models of diseased human tissue that emulate well the associated mechanical changes would be valuable. To this end, we studied the effect on mechanical response of treating porcine thoracic aorta with collagenase, elastase and glutaraldehyde. The alterations in mechanical and failure properties were assessed via uniaxial tension testing. A constitutive model composed of the Gasser-Ogden-Holzapfel model, for elastic response, and a continuum damage model, for the failure, was also employed to provide a further basis for comparison [1,2]. For the concentrations used here it was found that: collagenase treated samples showed decreased fracture stress in the axial direction only; elastase treated samples showed increased fracture stress in the circumferential direction only; and glutaraldehyde samples showed no change in either direction. With respect to the proposed constitutive model, both collagenase and elastase had a strong effect on the fibre-related terms. The model more closely captured the tissue response in the circumferential direction, due to the smoother and sharper transition from damage initiation to complete failure in this direction. Finally, comparison of the results with those of tensile tests on diseased tissues suggests these treatments indeed provide a basis for creation of physical models of diseased arteries.

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Section: Parameter Fitting and Effects Of Digestion 421 Quality Ansupporting

confidence: 64%

Section: Mechanical Tests and Effects Of Digestionmentioning

confidence: 99%

Creating a model of diseased artery damage and failure from healthy porcine aorta

Noble

Smulders

Green

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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“…27 Using an identical protocol, the present authors determined that increasing loading rate significantly increased subfailure and ultimate stress and elastic modulus, and significantly decreased subfailure and ultimate strain. 53 Therefore, present results may underestimate stress and elastic modulus, and overestimate strains, in comparison to real-world BCAI.…”

Section: Effect Of Loading Rate and Storage Protocolmentioning

confidence: 68%

Biomechanical Characterization of Internal Layer Subfailure in Blunt Arterial Injury

et al. 2006

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Blunt carotid artery injuries occur in 0.3% of blunt injured patients and may lead to devastating neurological consequences. However, arterial mechanics leading to internal layer subfailure have not been quantified. Twenty-two human carotid artery segments and 18 porcine thoracic aorta segments were opened to expose the intimal side and longitudinally distracted to failure. Porcine aortas were a geometrically accurate model of human carotid arteries. Internal layer subfailures were identified using videography and correlated with mechanical data. Ninety-three percent (93%) of vessels demonstrated subfailure prior to catastrophic failure. All subfailures occurred on the intimal surface. Initial subfailure occurred at 79% of the stress and 85% of the strain to catastrophic failure in younger porcine specimens, compared to 44% and 60%, respectively, in older human specimens. In most cases, multiple subfailures occurred prior to catastrophic failure. Due to limitations in human specimen quality (age, prior storage), young and fresh porcine aorta specimens are likely a more accurate model of clinical blunt carotid artery injuries. Present results indicate that vessels are acutely capable of maintaining physiologic function following initial subfailure. Delayed symptomatology commonly associated with blunt arterial injuries is explained by this mechanics-based and experimentally quantified onset of subcatastrophic failure.

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“…This clamping device was capable to reduce the local effect efficiently. Researchers have reported contradicting results about the relationship of stress and strain rate [4,[29][30][31][32][33]. Tanaka and Fung [4] tested canine aorta, obtained from different places along the aorta tree, in Krebs Ringer solution at 37 • C, pH 7.3-7.4.…”

Section: Discussionmentioning

confidence: 99%