Mechanically tuned vascular graft demonstrates rapid endothelialization and integration into the porcine iliac artery wall

Maleckis, Kaspars; Kamenskiy, Alexey; Lichter, Eliezer Z.; Oberley‐Deegan, Rebecca E.; Dzenis, Yuris A.; MacTaggart, Jason N.

doi:10.1016/j.actbio.2021.01.047

Cited by 15 publications

(30 citation statements)

References 64 publications

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“…Compared with a standard polytetrafluoroethylene prosthesis, the synthetic material under study had better endothelization and colonization of stroma cells. Additionally, an elastomeric nanofibrillar prosthesis demonstrated rapid integration into the vascular bed in an experiment on rabbits [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta

Gorodkov

Tsygankov

Шепелев

et al. 2022

JFB

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A significant drawback of the rigid synthetic vascular prostheses used in the clinic is the mechanical mismatch between the implant and the prosthetic vessel. When placing prostheses with radial elasticity, in which this deficiency is compensated, the integration of the graft occurs more favorably, so that signs of cell differentiation appear in the prosthesis capsule, which contributes to the restoration of vascular tone and the possibility of vasomotor reactions. Aortic prostheses fabricated by electrospinning from a blend of copolymers of vinylidene fluoride with hexafluoropropylene (VDF/HFP) had a biomechanical behavior comparable to the native aorta. In the present study, to ensure mechanical stability in the conditions of a living organism, the fabricated blood vessel prostheses (BVP) were cross-linked with γ-radiation. An optimal absorbed dose of 0.3 MGy was determined. The obtained samples were implanted into the infrarenal aorta of laboratory animals—Landrace pigs. Histological studies have shown that the connective capsule that forms around the prosthesis has signs of high tissue organization. This is evidenced by the cells of the fibroblast series located in layers oriented along and across the prosthesis, similar to the orientation of cells in a biological arterial vessel.

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Section: Discussionmentioning

confidence: 99%

Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta

Gorodkov

Tsygankov

Шепелев

et al. 2022

JFB

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“…It is critical for the long-term patency of any vascular graft given that numerous studies have reported about complications and lost graft patency results from a mechanical mismatch between the graft and its adjoining natural vessel. 20,24,25 In the normal human blood pressure range, the compliance of the composite vascular graft was 3.03 AE 0.69%/100 mmHg. At hypotensive and hypertensive blood pressure ranges, the compliance of the composite graft was 3.93 AE 1.05%/100 mmHg and 3.35 AE 1.33%/100 mmHg, respectively (Table 2).…”

Section: The Composite Vascular Graft Has Sufficient Mechanical Strengthmentioning

confidence: 99%

A textile-reinforced composite vascular graft that modulates macrophage polarization and enhances endothelial cell migration, adhesion and proliferation in vitro

et al. 2023

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“…The complete remodeling of vascular wall structure is affected by many factors, such as the mechanical properties of materials, hemodynamics, plasma protein adhesion, and drug effects. 98,[201][202][203] Therefore, it is determined that the endothelialization design strategy should be a holistic consideration of the post-implantation pathological environment rather than surface modification under the influence of a single factor. This means that not only the effectiveness, feasibility, and time-sequence of the modification method need to be considered, but also the impact of the material surface on the entire vascular microenvironment, including cells, blood, and tissues (Figure 3): Implant material-Blood: After implantation, the material first faces the blood environment.…”

Section: Electrostatic Interaction 196 Selenium Compoundsmentioning

confidence: 99%

Endothelialization strategy of implant materials surface: The newest research in recent 5 years

Bian

Chen

Weng

et al. 2022

Journal of Applied Biomaterials & Functional Materials

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In recent years, more and more metal or non-metal materials have been used in the treatment of cardiovascular diseases, but the vascular complications after transplantation are still the main factors restricting the clinical application of most grafts, such as acute thrombosis and graft restenosis. Implant materials have been extensively designed and surface optimized by researchers, but it is still too difficult to avoid complications. Natural vascular endodermis has excellent function, anti-coagulant and anti-intimal hyperplasia, and it is also the key to maintaining the homeostasis of normal vascular microenvironment. Therefore, how to promote the adhesion of endothelial cells (ECs) on the surface of cardiovascular materials to achieve endothelialization of the surface is the key to overcoming the complications after implant materialization. At present, the surface endothelialization design of materials based on materials surface science, bioactive molecules, and biological function intervention and feedback has attracted much attention. In this review, we summarize the related research on the surface modification of materials by endothelialization in recent years, and analyze the advantages and challenges of current endothelialization design ideas, explain the relationship between materials, cells, and vascular remodeling in order to find a more ideal endothelialization surface modification strategy for future researchers to meet the requirements of clinical biocompatibility of cardiovascular materials.

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Mechanically tuned vascular graft demonstrates rapid endothelialization and integration into the porcine iliac artery wall

Cited by 15 publications

References 64 publications

Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta

Influence of γ-Radiation on Mechanical Stability to Cyclic Loads Tubular Elastic Matrix of the Aorta

A textile-reinforced composite vascular graft that modulates macrophage polarization and enhances endothelial cell migration, adhesion and proliferation in vitro

Endothelialization strategy of implant materials surface: The newest research in recent 5 years

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