Mechanically robust, photopatternable conductive hydrogel composites

Pal, Raktim; Turner, Emigdio E.; Chalfant, Benjamin H.; Yadavalli, Vamsi K.

doi:10.1016/j.reactfunctpolym.2017.09.006

Cited by 26 publications

(20 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was observed that the conductivity of GelMA‐PEDOT/PSS significantly increased from 6.1 × 10 −3 to 1 × 10 −2 S cm −1 , with an increase in the PEDOT/PSS content from 1 to 1.5 wt %. The cause of this phenomenon probably lie not only in the decent electrical conductivity of PEDOT/PSS that was dispersed uniformly in the polymeric network, but also in PSS that provides the continuous transporting path for electrons …”

Section: Resultsmentioning

confidence: 99%

“…The method used for obtaining electrically conductive hydrogels (ECHs) that can be used as an electro‐responsive drug carrier is to integrate conductive polymers such as polypyrrole, polyaniline, poly(3,4‐ethylenedioxythiophene) (PEDOT) into the hydrogel network structure. ECHs are employed for controlled drug release system as ECHs not only exhibit a strong combination of biocompatibility and conductivity but also have a three‐dimensional and crosslinked porous structure that can hold a large amount of the water . In addition, they change its volume or its shape in response to electric stimuli owing to their conductive properties …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Electrically controlled release of 5‐fluorouracil from conductive gelatin methacryloyl‐based hydrogels

Oktay

Alemdar

2018

J of Applied Polymer Sci

View full text Add to dashboard Cite

Herein, electro‐responsive hydrogels were obtained by incorporation of poly(3,4‐ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT/PSS) into the gelatin methacryloyl (GelMA) by using photopolymerization technique. Hydrogels were characterized by FTIR and scanning electron microscopy analyses. Cytotoxicity tests were performed by L929 cell lines to determine cell compatibility. Swelling tests were conducted to investigate the water uptake capacity of hydrogels. 5‐fluorouracil (5‐FU) was selected as a model drug as it is known as a topical drug for some skin cancer type treatment. The release of 5‐FU from the hydrogel was provided in efficient and controlled manner at simulated skin cancer (pH = 5.5) and under 0 and 1.5 V. The simulated drug delivery experiments conducted in vitro revealed that the drug releasing amount was higher when voltage is applied to the hydrogels. All results visualized that the obtained GelMA‐based PEDOT/PSS hydrogels with enhanced electrical properties could be a potential candidate as an electrically sensitive drug carrier for treatment of skin cancer in the future applications. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 46914.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrically controlled release of 5‐fluorouracil from conductive gelatin methacryloyl‐based hydrogels

Oktay

Alemdar

2018

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…CPH have been suggested as suitable candidates for interfacial modification since they can combine both electrochemical and biochemical qualities in one material . In recent years, a wide range of different CPHs have been suggested as interesting candidates for neural probes and many studies have investigated the micropatterning of CPHs, for example, via photolithography, inkjet printing, mold casting, or electrodeposition . Alternatively, it is possible to coat the entire device with the hydrogel and subsequently deposit the conducting polymer into the hydrogel matrix, so that a conducting network is formed at the electrode surfaces only .…”

Section: Discussionmentioning

confidence: 99%

“…In an ideal scenario, the CPH can then be coated onto selected electrode sites, for example, as a drug‐release system, while other electrodes remain available for alternative functionalizations. A possible method for micropatterning CPHs, based on a phytic acid gelated polyaniline hydrogel by inkjet printing or spray coating, has been reported by Pan et al Other reported techniques include mold casting, photolithography, or electrodeposition . Several CPHs used for neural interfaces are based on dip coating the hydrogel onto the entire surface of the device followed by the deposition of the CP selectively at the electrode site .…”

Section: Introductionmentioning

confidence: 99%

Wafer‐Scale Fabrication of Conducting Polymer Hydrogels for Microelectrodes and Flexible Bioelectronics

et al. 2019

View full text Add to dashboard Cite

Future‐oriented directions in neural interface technologies point towards the development of multimodal devices that combine different functionalities such as neural stimulation, neurotransmitter sensing, and drug release within one platform. Conducting polymer hydrogels (CPHs) are suggested as materials for the coating of standard metal electrodes to add functionalities such as local delivery of therapeutic drugs. However, to make such coatings truly useful for multimodal devices, it is necessary to develop process technologies that allow the micropatterning of CPHs onto selected electrode sites. In this study, a wafer‐scale fabrication procedure is presented, which is used to coat the CPH, based on the hydrogel P(DMAA‐co‐5%MABP‐co‐2,5%SSNa) and the conducting polymer poly(3,4‐ethylenedioxythiophene) (PEDOT), onto flexible neural probes. The resulting material has favorable properties for the generation of recording electrodes and in addition offers a convenient platform for biofunctionalization. By controlling the PEDOT content within the hydrogel matrix, charge injection limits of up to 3.7 mC cm−2 are obtained. Long‐term stability is tested by immersing coated samples in phosphate‐buffered saline solution at 37 °C for 1 year. Non‐cytotoxicity of the coatings is confirmed with a direct cell culture test using a fluorescent neuroblastoma cell line.

show abstract

“…However, the double network hydrogel can easily suffer from the irreversible softening and the non‐self‐healing due to the permanent fracture of the covalent bonds . Chen et al designed a highly stretchable hybrid double network hydrogel with excellent self‐healing property, but the shortcoming with poor tensile strength restricts its further application . When compared with double network hydrogel, the typical TN achieves excellent self‐healing and tensile strength due to its special network structure .…”

Section: Introductionmentioning

confidence: 99%

Bimetallic ions synergistic cross‐linking high‐strength rapid self‐healing antibacterial hydrogel

Wang

Feng

et al. 2018

Polymer Engineering & Sci

View full text Add to dashboard Cite

In this work, a novel PAA‐Fe3+‐Al3+ hydrogel with triple network structure (TN) was synthesized via bimetallic ions synergistic cross‐linking strategy. As‐synthesized samples were characterized by scanning electron microscope, Fourier transform infrared analysis, and X‐ray diffractometer. The relevant experiment results demonstrated that the hydrogel can rapidly self‐heal in ambient temperature without any external stimulus with 95% healing efficiency in 60 s. Simultaneously, the relatively rapid self‐healing of PAA‐Fe3+‐Al3+ polymer can be obtained through the coordination of metal ions with the COO− in PAA and the oxygen of agar in the TN hydrogel system. And the prepared hydrogels demonstrate excellent mechanical properties—high tensile strength (the tensile strain ≈ 1.011 mm/mm, tensile stress ≈ 0.34 MPa) and large elasticity (the elongation at break ≈ 74%). Especially, the antimicrobial activity of the novel hydrogel against Staphylococcus aureus and Escherichia coli bacteria was investigated using the inhibition zone method, showing remarkable antibacterial activity. POLYM. ENG. SCI., 59:919–927, 2019. © 2018 Society of Plastics Engineers

show abstract

Mechanically robust, photopatternable conductive hydrogel composites

Cited by 26 publications

References 57 publications

Electrically controlled release of 5‐fluorouracil from conductive gelatin methacryloyl‐based hydrogels

Electrically controlled release of 5‐fluorouracil from conductive gelatin methacryloyl‐based hydrogels

Wafer‐Scale Fabrication of Conducting Polymer Hydrogels for Microelectrodes and Flexible Bioelectronics

Bimetallic ions synergistic cross‐linking high‐strength rapid self‐healing antibacterial hydrogel

Contact Info

Product

Resources

About