Mechanically-reinforced biocompatible hydrogels based on poly(N-isopropylacrylamide) and star-shaped polycaprolactones

Damonte, Giacomo; Cozzani, Martina; Di Lisa, Donatella; Pastorino, Laura; Mariani, Alberto; Monticelli, Orietta

doi:10.1016/j.eurpolymj.2023.112239

Cited by 3 publications

(2 citation statements)

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“…As will be shown later by discussing the reviewed publications, the easiest way to increase the number of available systems lies in copolymerization and functionalization [42,43], the latter being generally employed to impart particular properties to the final material. Relative to copolymerization, as will be seen, the tendency is to use a reasonably small number of monomers (e.g., acrylamide, acrylic, itaconic acid, N-isopropylacrylamide, 2-hydroxyethylacrylate, etc.…”

Section: Monomersmentioning

confidence: 99%

Polymer Hydrogels and Frontal Polymerization: A Winning Coupling

Mariani,

Malucelli

2023

Polymers

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Polymer hydrogels are 3D networks consisting of hydrophilic crosslinked macromolecular chains, allowing them to swell and retain water. Since their invention in the 1960s, they have become an outstanding pillar in the design, development, and application of engineered polymer systems suitable for biomedical and pharmaceutical applications (such as drug or cell delivery, the regeneration of hard and soft tissues, wound healing, and bleeding prevention, among others). Despite several well-established synthetic routes for developing polymer hydrogels based on batch polymerization techniques, about fifteen years ago, researchers started to look for alternative methods involving simpler reaction paths, shorter reaction times, and lower energy consumption. In this context, frontal polymerization (FP) has undoubtedly become an alternative and efficient reaction model that allows for the conversion of monomers into polymers via a localized and propagating reaction—by means of exploiting the formation and propagation of a “hot” polymerization front—able to self-sustain and propagate throughout the monomeric mixture. Therefore, the present work aims to summarize the main research outcomes achieved during the last few years concerning the design, preparation, and application of FP-derived polymeric hydrogels, demonstrating the feasibility of this technique for the obtainment of functional 3D networks and providing the reader with some perspectives for the forthcoming years.

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Section: Monomersmentioning

confidence: 99%

Polymer Hydrogels and Frontal Polymerization: A Winning Coupling

Mariani,

Malucelli

2023

Polymers

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“…This property makes it suitable for drug delivery; applying a PNIPAM-based gel on the skin can increase drug retention in the epidermis and reduce drug penetration into the skin [84] . Shivshetty with tunable kinetic release and swelling ratio, biocompatibility, and thermo-reactivity [86] .…”

Section: Poly (N-isopropyl Acrylamide) Hydrogelsmentioning

confidence: 99%

Novel Studies in the Designs of Natural, Synthetic, and Compound Hydrogels with Biomedical Applications

Cuéllar Gaona,

Ibarra Alonso,

Narro Céspedes

et al. 2023

Rev. Mex. Ing. Biomed.

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Hydrogels are gaining widespread popularity in the biomedical field due to their extraordinary properties, such as biocompatibility, biodegradability, zero toxicity, easy processing, and similarity to physiological tissue. They have applications in controlled drug release, wound dressing, tissue engineering, and regenerative medicine. Among these applications, hydrogels as a controlled drug delivery system stands out, which releases active substances in precise amounts and at specific times. To explore the latest advances in the design of hydrogels, a literature review of articles published in indexed scientific journals, in Scopus and Science Direct, was carried out. This review aimed to discover and describe the most innovative hydrogel research with applications in the biomedical field; hydrogels synthesized with polymers of different origins were selected, such as; i. Natural (dextran, agarose, chitosan, etc.); ii. Synthetic (polyacrylamide, polyethylene glycol, polyvinyl alcohol, etc.); iii. Composites (interpenetrants, hybrid crosslinkers, nanocomposites, etc.). Comparative analysis revealed that hydrogels with composite materials show the most promise. These composite hydrogels combine the advantages of different polymers or incorporate additional components, offering enhanced properties and functionalities. In summary, hydrogels are versatile biomaterials with immense potential in biomedicine. Their unique properties make them suitable for diverse applications. However, innovative designs and formulations must continue to be explored to further advance the capabilities of hydrogels and expand their biomedical applications.

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