Mechanically induced defects in quartz and their impact on pathogenicity

Fubini, Bice; Giamello, Elio; Pugliese, Luisa; Volante, Marco

doi:10.1016/0167-2738(89)90238-5

Cited by 39 publications

(46 citation statements)

References 18 publications

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“…Figure 1 reports the typical spectrum of a pure quartz dust ground in dry air (a), after contact with oxygen and subsequent evacuation at 77 K (b), under 25 Tom of oxygen (c) and of the standard aged dust (Min-U-Sil), both in vacuum (d ), and under 25 Tom of oxygen (e). The spectra under vacuum have been largely discussed in previous papers (7,9); they are produced by the cleavage of Si-&Si bonds during grinding and subsequent reaction with atmospheric components. The final product is mainly SO2.…”

Section: Resultsmentioning

confidence: 99%

“…pointed out that these paramagnetic species are rather stable with time and mild thermal treatments (9). Moreover, the modifications detected in the EPR spectrum after long standing in aqueous solutions mimicking the biological environment do not seem to indicate that these particular radical species are the only initiators of the pathogenic process (10,11).…”

Section: Introductionmentioning

confidence: 99%

“…The spectra were recorded in vacuo at 77 K . These are appropriate conditions for detection of most of the surface paramagnetic species (9).…”

Section: Electron Spin Resonancementioning

confidence: 99%

“…Among the various surface functionalities which may be regarded as possible initiators of the chain of events ending up in formation of the pneumonoconiotic lesions typical of silicosis, surface radicals should be taken into account. Indeed, such a hypothesis has been recently put forward by some of us and other authors (7)(8)(9)(10)(11)(12)(13)(14)(15). Various radical centres are in fact present at the surface of freshly ground and of aged dusts, originated by rupture of the silicon-oxygen bond and subsequent reaction of dangling bonds with atmospheric components.…”

Section: Introductionmentioning

confidence: 99%

“…Various radical centres are in fact present at the surface of freshly ground and of aged dusts, originated by rupture of the silicon-oxygen bond and subsequent reaction of dangling bonds with atmospheric components. Active oxygen forms, such as silylperoxide, SiO2' and superoxide 0 2 -anions, whose potential toxicity is widely accepted, have been suggested to exist on samples ground in air (8)(9)(10)(11)(12). The assignments have been made on the basis of literature data both on bulk (16,17) and on powdered samples (18)(19)(20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

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A novel type of active site at the surface of crystalline SiO₂ (a-quartz) and its possible impact on pathogenicity

Costa¹,

Fubini²,

Giamello³

et al. 1991

Can. J. Chem.

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A new type of surface site, different from those previously described, which gives rise to a paramagnetic oxygen species upon adsorption of 0 2 at low temperature, has been found at the surface of crystalline quartz. This site is abundant on freshly cleaved surfaces or on chemically etched ones but absent on crystal growth faces or on samples annealed at high temperature. The abundance of this site is not related to the other surface radicals characteristic of the quartz surface originated by mechanical grinding in air. The EPR spectral features of the signal suggest an ozonide type radical 03-. The adsorption of oxygen onto quartz dusts variously treated in order to modulate their fibrogenic potential in vivo indicates that a relationship may exist between the presence of this site and quartz pathogenicity.Key words: quartz, oxygen radical species, ozonide, silicosis, EPR.DOMINIQUE COSTA, BICE FUBINI, ELIO GIAMELLO et MARCO VOLANTE. Can. J. Chern. 69, 1427 (1991).On a trouvC i la surface du quartz cristallin un nouveau site de surface, diffkrent de ceux dCcrits anterieurement, qui conduit i une espkce d'oxygkne paramagnktique lors de l'adsorption de l'oxygkne i basse tempkrature. Ce site se trouve en abondance sur les surfaces fraichement coupCes ou sur celles qui sont dCcapCes alors qu'il est absent sur les faces des cristaux en croissance ou sur des Cchantillons condensCs i haute tempirature. L'abondance de ce site n'est pas reliC aux radicaux de surface caractCristiques de la surface du quartz travaillke par broyage mkcanique dans l'air. Les caractkristiques spectrales du signal en W E suggkrent un radical du type ozonide 0 3 -. L'adsorption de l'oxyg5ne sur de la poussikre de quartz, traitke de diffCrentes faqons dans le but de moduler leur potentiel fibrogknique in vivo, indique qu'il peut exister une relation entre la prCsence de ce site et la pathonCgicitC du quartz.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The spectra were recorded in vacuo at 77 K . These are appropriate conditions for detection of most of the surface paramagnetic species (9).…”

Section: Electron Spin Resonancementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A novel type of active site at the surface of crystalline SiO₂ (a-quartz) and its possible impact on pathogenicity

Costa¹,

Fubini²,

Giamello³

et al. 1991

Can. J. Chem.

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Reaction with Water Vapor Defines Surface Reconstruction and Membranolytic Activity of Quartz Milled in Different Molecular Environments

Bellomo,

Lagostina,

Pavan

et al. 2023

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Industrial processing of quartz (SiO2) and quartz‐containing materials produces toxic dust. Fracturing quartz crystals opens the Si‒O bond and produces highly reactive surface species which mainly react with molecules like water and oxygen. This surface‐reconstruction process forms silanol (Si‒OH) on the quartz surface, which can damage biological membranes under specific configurations. To comprehend the impact of the quartz surface restructuring on membranolytic activity, the formation and reactivity of quartz radicals produced in four distinct molecular environments with electron paramagnetic resonance (EPR) spectroscopy are evaluated and their membranolytic activity is measured through in vitro hemolysis test. The four molecular environments are formulated with and without molecular water vapor and oxygen (±H2O/±O2). The absence of water favored the formation of surface radical species. In water‐rich environments, diamagnetic species prevailed due to radical recombination. Quartz milled in −H2O/±O2 acquired membranolytic activity when exposed to water vapor, unlike quartz milled in +H2O/±O2. After being stabilized by reaction with water vapor, the membranolytic activity of quartz is maintained over time. It is demonstrated that the type and the reactivity of radical sites on quartz are modulated by the outer molecular environment, ultimately determining the biological activity of milled quartz dust.

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The surface reactivity and implied toxicity of ash produced from sugarcane burning

Blond

Tomatis

Horwell

et al. 2012

Environmental Toxicology

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58'scavenge' an external source of hydroxyl radicals, which may be indicative of defects on the 59 particle surfaces that may interfere with cellular processes. The bio-available iron on the particle 60 surfaces was low (2-3 µmol m -2 ) indicating a low propensity for iron-catalysed radical generation. 61The sample surfaces were all hydrophilic and slightly acidic, which may be due to the presence of

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Mechanically induced defects in quartz and their impact on pathogenicity

Cited by 39 publications

References 18 publications

A novel type of active site at the surface of crystalline SiO₂ (a-quartz) and its possible impact on pathogenicity

A novel type of active site at the surface of crystalline SiO₂ (a-quartz) and its possible impact on pathogenicity

Reaction with Water Vapor Defines Surface Reconstruction and Membranolytic Activity of Quartz Milled in Different Molecular Environments

The surface reactivity and implied toxicity of ash produced from sugarcane burning

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Mechanically induced defects in quartz and their impact on pathogenicity

Cited by 39 publications

References 18 publications

A novel type of active site at the surface of crystalline SiO2 (a-quartz) and its possible impact on pathogenicity

A novel type of active site at the surface of crystalline SiO2 (a-quartz) and its possible impact on pathogenicity

Reaction with Water Vapor Defines Surface Reconstruction and Membranolytic Activity of Quartz Milled in Different Molecular Environments

The surface reactivity and implied toxicity of ash produced from sugarcane burning

Contact Info

Product

Resources

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A novel type of active site at the surface of crystalline SiO₂ (a-quartz) and its possible impact on pathogenicity

A novel type of active site at the surface of crystalline SiO₂ (a-quartz) and its possible impact on pathogenicity