Mechanical ventilation: past lessons and the near future

Marini, John J.

doi:10.1186/cc11499

Cited by 41 publications

(32 citation statements)

References 62 publications

(60 reference statements)

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“…Actually, widespread use of protective ventilation in patients without ARDS is still an M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 9 ongoing debate (36,37), but evidence favoring its use in all mechanically ventilated patients is growing (34). In the specific setting of cardiac surgery, there is a strong rationale for using protective ventilation.…”

Section: Tidal Volumementioning

confidence: 99%

Perioperative ventilatory strategies in cardiac surgery

Lellouche

Delorme

Bussières

et al. 2015

Best Practice & Research Clinical Anaesthesiology

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Section: Tidal Volumementioning

confidence: 99%

Perioperative ventilatory strategies in cardiac surgery

Lellouche

Delorme

Bussières

et al. 2015

Best Practice & Research Clinical Anaesthesiology

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“…It is associated with various side effects, including injury to the airways and lung parenchyma due to its invasive nature (9). These side effects led to the invention of modern mechanical ventilation methods including high frequency oscillatory ventilation (HFOV), which can be set to trigger or to coincide with the baby's inspiratory efforts (10,11).…”

Section: Introductionmentioning

confidence: 99%

Different ventilation modes combined with ambroxol in the treatment of respiratory distress syndrome in premature infants

Zhou

Zhai

et al. 2016

Experimental and Therapeutic Medicine

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The aim of the present study was to compare the effectiveness of different modes of mechanical ventilation in combination with secretolytic therapy with ambroxol in premature infants with respiratory distress syndrome. Seventy-three premature infants with hyaline membrane disease (HMD) (stage III–IV), also known as respiratory distress syndrome, who were supported by mechanical ventilation in the neonatal intensive care unit (NICU) of Xuzhou Central Hospital, were involved in the present study, between January 2013 and February 2015. Forty cases were randomly selected and treated with high frequency oscillatory ventilation (HFOV), forming the HFOV group, whereas 33 cases were selected and treated with conventional mechanical ventilation (CMV), forming the CMV group. Patients in the two groups were administered ambroxol intravenously at a dosage rate of 30 mg/kg body weight at the beginning of the study. The present study involved monitoring the blood gas index as well as changes in the respiratory function index in the two groups. Additionally, the incidence of complications in the premature infants in the two groups was observed prior to and following the ventilation. Pulmonary arterial oxygen tension (PaO2), the PaO2/fraction of inspired oxygen (FiO2) ratio, the oxygenation index [OI = 100 × mean airway pressure (MAP) × FiO2/PaO2], as well as the arterial/alveolar oxygen partial pressure ratio (a/APO2) = PaO2/(713 × FiO2 partial pressure of carbon dioxide (PaCO2)/0.8) of the patients in the HFOV group after 1, 12 and 24 h of treatment were significantly improved as compared to the patients of the CMV group. However, there was no significant difference between patients in the two groups with regard to the number of mortalities, complications such as pneumothorax, bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), intraventricular hemorrhage (IVH), periventricular leukomalacia (PVL), and the time of ventilation. In conclusion, combining HFOV with ambroxol secretolytic therapy is a more viable option, as the combined treatment resulted in significant improvements in arterial blood gas levels, oxygenation and the respiratory function of lungs in preterm infants.

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“…This expansion of extracorporeal support beyond life-threatening hypoxemia to life-threatening ventilator-associated lung injury remains to be tested (148). …”

Section: Therapy To Alter the Trajectory Of Ardsmentioning

confidence: 99%

Reducing the Burden of Acute Respiratory Distress Syndrome

Fuller¹,

Mohr

Hotchkiss³

et al. 2014

Shock

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The mortality for acute respiratory distress syndrome (ARDS) remains unacceptably high. Success in clinical trials has been limited, resulting in a lack of effective therapies to treat the syndrome. The projected increase in mechanically ventilated patients and global need for critical care services suggests that the clinical and research landscape in ARDS can no longer be confined to the intensive care unit (ICU). A demonstrable minority of patients present to the emergency department (ED) with ARDS, and ARDS onset typically occurs shortly after ICU admission. Furthermore, the ED is an entry point for many of the highest risk patients for ARDS development and progression. These facts, combined with prolonged lengths of stay in the ED, suggest that the ED could represent a window of opportunity for treatment and preventive strategies, as well as clinical trial enrollment. This review aims to discuss some of the potential strategies which may prevent or alter the trajectory of ARDS, with a focus on the potential role the ED could play in reducing the burden of this syndrome.

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Mechanical ventilation: past lessons and the near future

Cited by 41 publications

References 62 publications

Perioperative ventilatory strategies in cardiac surgery

Perioperative ventilatory strategies in cardiac surgery

Different ventilation modes combined with ambroxol in the treatment of respiratory distress syndrome in premature infants

Reducing the Burden of Acute Respiratory Distress Syndrome

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