Mechanical support of total cavopulmonary connection with an axial flow pump

Riemer, R. Kirk; Amir, Gabriel; Reichenbach, Steven H.; Reinhartz, Olaf

doi:10.1016/j.jtcvs.2004.12.037

Cited by 61 publications

(47 citation statements)

References 8 publications

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“…A new design, recently presented 21 by this team, indicates their exploration of a unique bi-conical impeller pump or disk to stabilize flow directionality in the TCPC junction. Riemer et al 19 at the Stanford University have used a sheep model of the TCPC to test the response to the Thoratec HeartMate II axial flow blood pump (Thoratec Corporation, Pleasanton, CA, USA). These studies demonstrated a baseline return of cardiac output, IVC flow, and arterial pressures.…”

Section: Discussionmentioning

confidence: 99%

Numerical, Hydraulic, and Hemolytic Evaluation of an Intravascular Axial Flow Blood Pump to Mechanically Support Fontan Patients

et al. 2010

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Currently available mechanical circulatory support systems are limited for adolescent and adult patients with a Fontan physiology. To address this growing need, we are developing a collapsible, percutaneously-inserted, axial flow blood pump to support the cavopulmonary circulation in Fontan patients. During the first phase of development, the design and experimental evaluation of an axial flow blood pump was performed. We completed numerical modeling of the pump using computational fluid dynamics analysis, hydraulic testing of a plastic pump prototype, and blood bag experiments (n=7) to measure the levels of hemolysis produced by the pump. Statistical analyses using regression were performed. The prototype with a 4-bladed impeller generated a pressure rise of 2-30 mmHg with a flow rate of 0.5-4 L/min for 3000-6000 RPM. A comparison of the experimental performance data to the numerical predictions demonstrated an excellent agreement with a maximum deviation being less than 6%. A linear increase in the plasma-free hemoglobin (pfHb) levels during the 6-h experiments was found, as desired. The maximum pfHb level was measured to be 21 mg/dL, and the average normalized index of hemolysis was determined to be 0.0097 g/100 L for all experiments. The hydraulic performance of the prototype and level of hemolysis are indicative of significant progress in the design of this blood pump. These results support the continued development of this intravascular pump as a bridge-to-transplant, bridge-to-recovery, bridge-to-hemodynamic stability, or bridge-to-surgical reconstruction for Fontan patients.

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Section: Discussionmentioning

confidence: 99%

Numerical, Hydraulic, and Hemolytic Evaluation of an Intravascular Axial Flow Blood Pump to Mechanically Support Fontan Patients

et al. 2010

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“…The prospect of a mechanical Fontan support device has been raised and a number of designs have undergone mathematical modeling (160,161) and animal studies. (162)(163)(164) Conflict of interest: none declared.…”

Section: Role Of Transplantationmentioning

confidence: 99%

Management of the Fontan circulation in the adult patient

Clift

2017

SAHJ

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“…· Reports of ventricular assist device use in Fontan patients are rare and in general document technical aspects of the implant, clinical improvement, and a successful bridge to transplantation [47–50]. There is only one reported case using a total artificial heart in a single-ventricle Fontan patient who recovered and eventually went on to have heart transplant [51].…”

Section: Assist Devicesmentioning

confidence: 99%

Fontan Liver Disease: Review of an Emerging Epidemic and Management Options

Bradley

Hendrickson

Daniels

2015

Curr Treat Options Cardio Med

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Opinion statement Adults with complex congenital heart disease that resulted in a Fontan procedure frequently experience late cardiac failure. Increasingly, liver disease is recognized as an important complication of single-ventricle anatomy and Fontan physiology; however, there is no consensus regarding liver evaluation in this population. Here, we review what is known about liver disease in this unique group and propose screening and prevention measures. We also review controversial treatment areas including assist devices and transplantation, with a review of outcomes in isolated heart and combined heart-liver transplant.

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Mechanical support of total cavopulmonary connection with an axial flow pump

Cited by 61 publications

References 8 publications

Numerical, Hydraulic, and Hemolytic Evaluation of an Intravascular Axial Flow Blood Pump to Mechanically Support Fontan Patients

Numerical, Hydraulic, and Hemolytic Evaluation of an Intravascular Axial Flow Blood Pump to Mechanically Support Fontan Patients

Management of the Fontan circulation in the adult patient

Fontan Liver Disease: Review of an Emerging Epidemic and Management Options

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