Mechanical stress induces expression of cytokines in human periodontal ligament cells

Yamamoto, Toshiro; Kita, Masakazu; Kimura, Ikuo; Oseko, Fumishige; Terauchi, Ryu; Takahashi, Kenji; Kubo, Toshikazu; Kanamura, Narisato

doi:10.1111/j.1601-0825.2005.01179.x

Cited by 67 publications

(52 citation statements)

References 15 publications

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“…The results of the current study indicate that various fibroblastic cells naturally produce OPG, thereby supporting the inhibitory roles of fibroblasts on osteoclastogenesis. There are also significant findings showing that mechanical force induces the production of both OPG and RANKL by PLF, while OPG is predominant over RANKL [Yamamoto et al, 2006;Nakajima et al, 2008;Kook et al, 2009]. Importantly, however, the results from GCF analysis showed that the levels of RANKL are naturally higher than those of OPG in this cell type.…”

Section: Discussionmentioning

confidence: 68%

Human periodontal ligament fibroblasts stimulate osteoclastogenesis in response to compression force through TNF-α-mediated activation of CD4+ T cells

2011

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Periodontal ligament fibroblasts (PLF) sense and respond to mechanical stimuli and participate in alveolar bone resorption during orthodontic treatments. This study examined how PLF influence osteoclastogenesis from bone marrow-derived macrophages (BMM) after application of tension or compression force. We also investigated whether lymphocytes could be a primary stimulator of osteoclastic activation during alveolar bone remodeling. We found that mechanical forces inhibited osteoclastic differentiation from BMM in co-cultures with PLF, with PLF producing predominantly osteoprotegerin (OPG) rather than receptor activator of nuclear factor-kappaB (NF-κB) ligand (RANKL). In particular, PLF increased the expression of tumor necrosis factor (TNF)-α in response to compression. Additional experiments showed the presence of CD4- and B220-positive cells with a subsequent increase in tartrate-resistant acid phosphatase (TRAP)-positive cells and RANKL expression only at the compression side of the force-subjected periodontal tissues. Exogenous TNF-α increased the number of TRAP-positive cells and pit formation in the co-cultures of BMM with Jurkat, but not with BJAB cells and this effect was almost completely inhibited by antibodies to TNF-α or TNF receptor. Collectively, the current findings suggest that PLF secrete relatively higher levels of TNF-α at the compression side than at the tension side and this imbalance leads to RANKL expression by activating CD4+ T cells, thereby facilitating bone resorption during orthodontic tooth movement.

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Section: Discussionmentioning

confidence: 68%

Human periodontal ligament fibroblasts stimulate osteoclastogenesis in response to compression force through TNF-α-mediated activation of CD4+ T cells

2011

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“…In addition, clinical studies have demonstrated that levels of cytokines, such as interleukin (IL) 1β, IL8, and cyclooxygenase (COX) 2, are increased in gingival crevicular fluid in orthodontic patients during active therapy [25]. Although the enhanced production of proinflammatory cytokines may indeed be due to the additional plaque accumulation caused by orthodontic appliances, a number of invitro studies point to the fact that these molecules can also be upregulated by biomechanical forces [28,32]. Therefore, orthodontic forces in combination with occlusal forces could accelerate periodontal destruction by the enhancement of periodontal inflammation.…”

Section: Introductionmentioning

confidence: 99%

“…Interleukin (IL) 1β, IL8 und Zyklooxygenase (COX) 2 in der gingivalen Sulkusflüssigkeit bei kieferorthopädischen Patienten wäh-rend der aktiven Therapie erhöht ist [25]. Obwohl die verstärkte Synthese proinflammatorischer Zytokine tatsächlich die Folge einer verstärkten Plaqueakkumulation durch kieferorthopädische Geräte sein könnte, so deuten doch zahlreiche In-vitro-Studien darauf hin, dass die Synthese von Entzündungsmolekülen auch durch biomechanische Kräfte induziert werden kann [28,32]. Somit könnten kieferorthopädische Kräfte in Verbindung mit okklusalen Belastungen den Abbau des Parodonts durch eine Verstärkung der parodontalen Entzündung beschleunigen.…”

Section: Introductionunclassified

Contribution of Orthodontic Load to Inflammationmediated Periodontal Destruction

et al. 2010

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“…Our pattern (a) is also related to interleukin 8 (IL-8). It was reported that mechanical stress induced expression of IL-8 and IL-6 in human periodontal ligament cells [10]. Mast cells may be influenced by barometric pressure and be an important source of TNFalpha and IL-6 [11].…”

Section: (A)mentioning

confidence: 99%

A probabilistic approach for links between rheumatic diseases and weather

Morimoto¹

2017

Int Med Care

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Rheumatoid arthritis (RA) is an autoimmune disorder characterized by a painful swelling that can eventually result in bone erosion and joint deformity. Many works have studied the effect of weather on arthritis and rheumatism. However, some studies showed that the relationship was not clinically significant, and thus scientific evidence on the link remains sparse and non-conclusive. The aim of this paper is to clarify what sort of changes of weather factors lead to the deterioration of the symptom of RA by a probabilistic method in conjunction with cytokine network.As a method, we chose a naive Bayes classifier rather than usual regression models. While a naive Bayes classifier is normally used for the problem of discrimination, we invented a new application of naive Bayes and applied it to calculate the tendency of meteorological factors towards high risk of deterioration of RA. Among meteorological factors, we selected barometric pressure and relative humidity.We identified three patterns of tendencies of weather factors that led to deterioration of rheumatic diseases. These findings suggested mechanisms connecting weather and RA. The differences of three patterns were associated with the varied responses of cytokine network including interleukin IL-6 as a key cytokine. Our findings are expected to contribute to avoid the event of destructive deterioration of RA on the basis of daily observation of the weather.

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Mechanical stress induces expression of cytokines in human periodontal ligament cells

Abstract: These results suggest that hPDL cells may play a role in the production of cytokines in response to mechanical stress in vivo.

Cited by 67 publications

References 15 publications

Human periodontal ligament fibroblasts stimulate osteoclastogenesis in response to compression force through TNF-α-mediated activation of CD4+ T cells

Human periodontal ligament fibroblasts stimulate osteoclastogenesis in response to compression force through TNF-α-mediated activation of CD4+ T cells

Contribution of Orthodontic Load to Inflammationmediated Periodontal Destruction

A probabilistic approach for links between rheumatic diseases and weather

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