Mechanical stress combines with planar polarised patterning during metaphase to orient embryonic epithelial cell divisions
Guy B. Blanchard,
Elena Scarpa,
Leila Muresan
et al.
Abstract:The planar orientation of cell division (OCD) is important for epithelial morphogenesis and homeostasis. We ask how mechanics and antero-posterior (AP) patterning combine to influence the first divisions after gastrulation in the Drosophila embryonic epithelium.
We analyse hundreds of cell divisions and show that stress anisotropy, notably from compressive forces, can reorient division directly in metaphase. Stress anisotropy influences the OCD by imposing cell elongation, despite mitotic roundi… Show more
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