Mechanical strain regulates osteogenesis via Antxr1/LncRNA H19/Wnt/β‐catenin axis
Lifei Liu,
Jianmin Guo,
Xiaoyang Tong
et al.
Abstract:Alleviating bone loss is an essential way to prevent osteoporotic fractures. Proper exercise improves bone density without the side effects of long‐term medications, but the mechanism is unclear. Our study explored the role of Antxr1/LncRNA H19/Wnt/β‐catenin axis in the process of exercise‐mediated alleviation of bone loss. Here we discovered that moderate‐intensity treadmill exercise alleviates bone loss caused by ovariectomy and ameliorates bone strength accompanied by an increased lncRNA H19 expression. Con… Show more
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