Mechanical strain, induced noninvasively in the high-frequency domain, is anabolic to cancellous bone, but not cortical bone

Rubin, Clinton T.; Turner, A. Simon; Mallinckrodt, Craig; Jerome, Christopher P.; McLeod, Kenneth J.; Bain, Steven D.

doi:10.1016/s8756-3282(01)00689-5

Cited by 258 publications

(262 citation statements)

References 37 publications

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“…Furthermore, it is likely the body of the animal also received at least a certain component of the physical signal despite efforts to primarily target the cranium. As in previous studies [6,14,15,37], systemic perturbations were not evident but cannot be excluded as a factor that influenced the results. Finally, transmissibility Fig.…”

Section: Discussionmentioning

confidence: 57%

Extremely Small-magnitude Accelerations Enhance Bone Regeneration: A Preliminary Study

Hwang

Lublinsky

Seo

et al. 2008

Clin Orthop Relat Res

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High-frequency, low-magnitude accelerations can be anabolic and anticatabolic to bone. We tested the hypothesis that application of these mechanical signals can accelerate bone regeneration in scaffolded and nonscaffolded calvarial defects. The cranium of experimental rats (n = 8) in which the 5-mm bilateral defects either contained a collagen scaffold or were left empty received oscillatory accelerations (45 Hz, 0.4 g) for 20 minutes per day for 3 weeks. Compared with scaffolded defects in the untreated control group (n = 6), defects with a scaffold and subject to oscillatory accelerations had a 265% greater fractional bone defect area 4 weeks after the surgery. After 8 weeks of healing (1-week recovery, 3 weeks of stimulation, 4 weeks without stimulation), the area (181%), volume (137%), and thickness (53%) of the regenerating tissue in the scaffolded defect were greater in experimental than in control animals. In unscaffolded defects, mechanical stimulation induced an 84% greater bone volume and a 33% greater thickness in the defect. These data provide preliminary evidence that extremely low-level, high-frequency accelerations can enhance osseous regenerative processes, particularly in the presence of a supporting scaffold.

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Section: Discussionmentioning

confidence: 57%

Extremely Small-magnitude Accelerations Enhance Bone Regeneration: A Preliminary Study

Hwang

Lublinsky

Seo

et al. 2008

Clin Orthop Relat Res

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“…The anabolic effects of HF loading on bone and bone healing have been reported in several animal [16][17][18]42] and clinical trials [19,20]. It is well established that bone has the potential of sensing and responding to very small mechanical signals when applied at HF [43]. Since the process of osseointegration of oral implants involves the bone healing process, it was assumed that HF loading might positively affect peri-implant bone healing and osseointegration.…”

Section: Discussionmentioning

confidence: 99%

“…Estrogens are known to regulate the rate and extent of bone remodeling, but the bone homeostasis balance is probably modulated by the prevailing mechanical environment [45]. Also, this phenomenon was observed only in the region where bone formation (modeling) takes place and not at the cortical, remodeling region [43]. The differential effect of HF WBV on the OVX cortical versus trabecular bone could be explained by the presence of decreased cortical bone mass and the correlation of the tissue response to HF loading to the bone mass, as observed by Judex et al [46].…”

Section: Discussionmentioning

confidence: 99%

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

et al. 2014

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Summary High-frequency loading via whole body vibration promotes bone formation and increases bone strength. Whether this translates to positive titanium implant osseointegration in osteoporotic bone was explored in this animal study. An anabolic effect of not only bisphosphonate treatment but also high-frequency loading on implant osseointegration in osteoporotic bone was observed. Introduction The present study investigated the impact of high-frequency (HF) loading, applied via whole body vibration (WBV), on titanium implant osseointegration in healthy versus ovariectomyinduced compromised versus pharmacologically treated compromised bone. Methods A custom-made Ti implant was inserted into the metaphyseal tibia of 59 rats and left to heal for either 4 or 14 days. Rats were divided into six groups according to their hormonal and mechanical status. WBV, consisting of 10 consecutive frequency steps at an acceleration of 0.3g, was applied daily for either 4 or 14 days. Tissue samples were processed for quantitative histology at the tibial cortical and medullar level. Data were analyzed by three-way ANOVA and by post hoc pairwise comparisons. Results The bone healing response at the interface and surrounding titanium implants was negatively influenced by osteoporotic bone conditions, mainly at the trabecular bone level. Furthermore, the administration of bisphosphonates for preventing the ovariectomy-induced impaired periimplant response was successful. Finally, the effect of HF WBV loading on the peri-implant bone healing was dependent on the bone condition and was anabolic solely in untreated osteoporotic trabecular bone when applied for an extended period of time. ConclusionsThe bone healing response to implant installation is compromised in osteoporotic bone conditions, in particular at the trabecular bone compartment. Meanwhile, not only pharmacological treatment but also mechanical loading via HF WBV can exert a positive effect on implant osseointegration in this specific bone micro-environment. The peri-implant cortical bone, however, seems to be less sensitive to HF WBV loading influences.

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“…20 Emphasizing the mechanical nature of the stimulus, vibrations do not produce systemic skeletal changes, but act in a local, sitespecific manner. 21 Despite successes of WBV in small-scale clinical trials, 22,23 an apparent limitation is its reliance on weight bearing as only bones of the lower and axial skeleton can be targeted by standing on a vibrating plate. Confining the anabolic response to weightbearing bones excludes skeletons incapable of bearing weight (e.g., patients with spinal injuries or muscular dystrophy) or clinically important sites not associated with weight bearing (e.g., distal radius).…”

Section: Introductionmentioning

confidence: 99%

Low‐level accelerations applied in the absence of weight bearing can enhance trabecular bone formation

Garman

Gaudette

Donahue

et al. 2007

Journal Orthopaedic Research

141

135

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High-frequency whole body vibrations can be osteogenic, but their efficacy appears limited to skeletal segments that are weight bearing and thus subject to the induced load. To determine the anabolic component of this signal, we investigated whether low-level oscillatory displacements, in the absence of weight bearing, are anabolic to skeletal tissue. A loading apparatus, developed to shake specific segments of the murine skeleton without the direct application of deformations to the tissue, was used to subject the left tibia of eight anesthesized adult female C57BL/6J mice to small (0.3 g or 0.6 g) 45 Hz sinusoidal accelerations for 10 min/day, while the right tibia served as an internal control. Video and strain analysis revealed that motions of the apparatus and tibia were well coupled, inducing dynamic cortical deformations of less than three microstrain. After 3 weeks, trabecular metaphyseal bone formation rates and the percentage of mineralizing surfaces (MS/BS) were 88% and 64% greater (p < 0.05) in tibiae accelerated at 0.3 g than in their contralateral controls. At 0.6 g, bone formation rates and mineral apposition rates were 66% and 22% greater (p < 0.05) in accelerated tibiae. Changes in bone morphology were evident only in the epiphysis, where stimulated tibiae displayed significantly greater cortical area (þ8%) and thickness (þ8%). These results suggest that tiny acceleratory motions -independent of direct loading of the matrix -can influence bone formation and bone morphology. If confirmed by clinical studies, the unique nature of the signal may ultimately facilitate the stimulation of skeletal regions that are prone to osteoporosis even in patients that are suffering from confinement to wheelchairs, bed rest, or space travel. ß

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Mechanical strain, induced noninvasively in the high-frequency domain, is anabolic to cancellous bone, but not cortical bone

Cited by 258 publications

References 37 publications

Extremely Small-magnitude Accelerations Enhance Bone Regeneration: A Preliminary Study

Extremely Small-magnitude Accelerations Enhance Bone Regeneration: A Preliminary Study

High-frequency loading positively impacts titanium implant osseointegration in impaired bone

Low‐level accelerations applied in the absence of weight bearing can enhance trabecular bone formation

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