Mechanical stimuli-driven cancer therapeutics

An, Jusung; Hong, Hyunsik; Won, Miae; Rha, Hyeonji; Ding, Qihang; Kang, Nayeon; Kim, Jong Seung

doi:10.1039/d2cs00546h

Cited by 50 publications

(38 citation statements)

References 88 publications

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“…The medicine can penetrate the membrane more deeply and without harm thanks to the US. The medication accumulates through passive diffusion once the carrier is broken, which causes pores to form in the cell membrane [ 174 ]. The power density, concentration, and the nature (hydrophilic or hydrophobic) of the medicine and the process used for the US, are necessary to be taken into account for the careful application of US.…”

Section: Polymeric Micellar Systems With “Smart” Responsivenessmentioning

confidence: 99%

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The 21st century has seen a transformation in the study of medicine thanks to the advancement in the field of material science and nanomedicine. Improved drug delivery systems with proven efficacy and fewer side effects have been made possible. Nanoformulations with varied functions are being created using lipids, polymers, and inorganic and peptide-based nanomedicines. Therefore, thorough knowledge of these intelligent nanomedicines is crucial for developing very promising drug delivery systems. Polymeric micelles are often simple to make and have high solubilization characteristics; as a result, they seem to be a promising alternative to other nanosystems. Even though recent studies have provided an overview of polymeric micelles, here we included a discussion on the “intelligent” drug delivery from these systems. We also summarized the state-of-the-art and the most recent developments of polymeric micellar systems with respect to cancer treatments. Additionally, we gave significant attention to the clinical translation potential of polymeric micellar systems in the treatment of various cancers.

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Section: Polymeric Micellar Systems With “Smart” Responsivenessmentioning

confidence: 99%

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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“…6a). 83 In 2021, Ye's group designed a nanocarrier that is simply degraded upon ultrasound activation to release its pre-loaded substances for ultrasound-induced ferroptosis. 46 In detail, among the released components such as metal ions and radical generators, Fe 2+ ions and Cu 2+ ions react with high level of H 2 O 2 in MKN45 (gastric cancer) cells to produce ROS for lipid peroxidation-mediated ferroptosis.…”

Section: Ultrasound-induced Ferroptosismentioning

confidence: 99%

Stimuli-responsive ferroptosis for cancer therapy

et al. 2023

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“…In addition to the in situ self-assembly method using endogenous stimuli, exogeneous stimuli-mediated in situ self-assembly is a promising spatiotemporal method with safe and deep tissue penetrability for inducing the eradication of cancer cells. 48 For instance, Cheng's group presented a mechanical-thermal induction therapy (MTIT) strategy for a programmable ROS increase by harnessing magnetically-derived self-assembly nanocubes ( RGD-MNPs ) integrated via magneto-inductions. 49 The external magneto-based mechanical and thermal stimuli effectively generate in situ self-assemblies, which can disrupt the lysosomes leading to sequentially induced dysfunction of mitochondria with synergistic therapeutic effects of mechanical forces and heat (according to magnetic field frequencies).…”

Section: -D Nanomaterials For Cancer Therapymentioning

confidence: 99%