Mechanical solutions to salvage failed distraction osteogenesis in large bone defect management

Borzunov, D.Yu.; Shastov, A. L.

doi:10.1007/s00264-018-4032-6

Cited by 29 publications

(31 citation statements)

References 24 publications

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“…Bone graft therapy is currently the most common clinical treatment. 1 However, there are several factors that limit the use of this clinical therapy, including bone-related disorders and limited donor supplies. 2 Recently, tissue engineering has become a promising approach for large bone defects regeneration.…”

Section: Introductionmentioning

confidence: 99%

Interleukin‐4‐loaded hydrogel scaffold regulates macrophages polarization to promote bone mesenchymal stem cells osteogenic differentiation via TGF‐β1/Smad pathway for repair of bone defect

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Interleukin‐4‐loaded hydrogel scaffold regulates macrophages polarization to promote bone mesenchymal stem cells osteogenic differentiation via TGF‐β1/Smad pathway for repair of bone defect

et al. 2020

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“…Patients who met the following criteria were included: (1) patient diagnosed as femoral bone defect; (2) treated by folded free vascularized bula graft; (3) patient with complete medical history and follow-up information.…”

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

“…As the main load-bearing bone of lower limb, the reconstruction of bone defect needs to consider the length of bone defect, the thickness of bone and the duration of disease [1] . Generally, segmental bone defects could be managed by several methods, such as Illizarov technique, induced membrane technique and bone graft [2] . Illizarov technique, which needs a long treatment course, has been criticized for related soft tissue and neurovascular complications.…”

Section: Introductionmentioning

confidence: 99%

Folded Free Vascularized Fibular Bone Graft for Segmental Femoral Bone Defect: a Retrospective Report

Jian

et al. 2021

Preprint

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ObjectiveVascularized fibular bone graft is an efficient method for various segmental bone defects. The objective of this report is to introduce our experience of folded free vascularized fibular bone graft for segmental femoral bone defect.Patients and methodsClinical data collected by surgeons and Hospital Information System (HIS) system were screened respectively. Cases with segmental femoral bone defect repaired by folded free vascularized fibular bone graft were collected. Clinical data including demographic characteristics, defect size, coinfection, perioperative treatment and imaging data during follow up were all collected for analysis.ResultsTwelve patients (10 males and 2 females), aged from 6 to 58, were included in this report. The defect range was 3 to 10 cm, with an average of 6.2 cm. Three cases were complicated with infection, the others were not. Folded free vascularized fibular bone graft were harvested for the reconstruction of segmental femoral bone defect. The grafts were fixed with plates in 9 cases and external fixators in 3 cases. All grafts healed uneventfully with an average healing time of 5.2 months (range 4~8 months). Internal fixation failure occurred in one case. The follow up time ranged from 15 to 130 months (average 58.3 months).ConclusionFolded free fibula graft is one of the optional methods for segmental bone defect of femur. Through this method, patients can achieve one-time operation to reconstruct the bone defect of the affected limb.

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“…Compared with the lower limbs, the upper limbs require more function than weight-bearing. Most studies about applying the Ilizarov technique in the treatment of bone defects were focused on the lower extremity [12][13][14][20][21][22][23][24], while there were few published data reported in the upper extremity due to the complexity of the bone transport procedure and for fear of functional loss [2,3,[25][26][27][28]. The purpose of our study was to evaluate the effectiveness of the Ilizarov segmental bone transport technique in the treatment of diaphyseal forearm bone defects caused by infection.…”

Section: Introductionmentioning

confidence: 99%

Treatment of diaphyseal forearm defects caused by infection using Ilizarov segmental bone transport technique

Liu

Yushan

Liu

et al. 2021

BMC Musculoskelet Disord

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Background The Ilizarov segmental bone transport technique can be applied in the reconstruction of the bone defects with less invasive fashion and more versatility compared to other methods, while most studies were focused on the lower extremity. The purpose of this study was to evaluate the effectiveness of the Ilizarov segmental bone transport technique in the treatment of diaphyseal forearm bone defects caused by infection. Methods This study included 12 patients with diaphyseal forearm bone defects caused by infection, who underwent bone transport procedures using the monolateral external fixator at our institution from January 2010 to January 2018, including 10 males and 2 females with a mean age of 39 years (range 23–57 years). Patient’s demographic data and clinical outcomes at least two years follow-up after removing the external fixator were collected and retrospectively analyzed. The functional results were evaluated by the questionnaire of Disability of Arm, Shoulder and Hand (DASH) and the modified Mayo wrist score (MWS) at the final follow-up. Results There were 10 radii and 2 ulnae bone transport procedures collected. The average defect size was 5.1 cm (4-6.5 cm). All patients were successfully followed up with a mean period of 28.2 months (24 to 36 months) and achieved infection-free union. There was no recurrence of infection observed. The mean external fixation time was 232.6 days (182 to 276 days), and the mean external fixation index was 46.3 days/cm (40.9 to 61.8 days/cm). The mean DASH score was 30.6(18 to 49) preoperative, while 13.8 (5 to 26) at the final follow-up. The average modified MWS improved from 68.8 (55 to 80) pre-operatively to 83.8 (65 to 90) at the final follow-up. All the differences between the preoperative and final scores were statistically significant (p < 0.05). Almost all the patients achieved satisfactory clinical outcomes and were able to perform activities of daily living. Conclusions Ilizarov segmental bone transport technique is an alternative and effective method for the treatment of diaphyseal forearm bone defects caused by infection, and this method acquired satisfactory clinical outcomes.

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Mechanical solutions to salvage failed distraction osteogenesis in large bone defect management

Abstract: The technical solutions used for mechanical effects on the ischaemic distraction regenerate resulted in its rescue and bone union in all the cases.

Cited by 29 publications

References 24 publications

Interleukin‐4‐loaded hydrogel scaffold regulates macrophages polarization to promote bone mesenchymal stem cells osteogenic differentiation via TGF‐β1/Smad pathway for repair of bone defect

Interleukin‐4‐loaded hydrogel scaffold regulates macrophages polarization to promote bone mesenchymal stem cells osteogenic differentiation via TGF‐β1/Smad pathway for repair of bone defect

Folded Free Vascularized Fibular Bone Graft for Segmental Femoral Bone Defect: a Retrospective Report

Treatment of diaphyseal forearm defects caused by infection using Ilizarov segmental bone transport technique

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