Mechanical simulator of the cardiovascular system

Zannoli, Romano; Corazza, Ivan; Branzi, Angelo

doi:10.1016/j.ejmp.2008.02.007

Cited by 42 publications

(31 citation statements)

References 8 publications

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“…Recent attempts have been able to physiologically mimic the atrium, ventricle, and vascular components, through the controlled use of pneumatic or hydraulic drives for flow, along with air tight integrated chambers to produce vascular resistance and compliance [19]. Although mock circulation loops provide a suitable test platform to evaluate cardiac assist devices [20,21] and their controllers performance [22,23], it has difficulty to produce complex nonlinear CV functions and implies high cost and compound mechanisms [24]. By focusing our attention on DMVA, it has not been shown how the mechanical interaction of these systems directly affects the complete mock circulatory system.…”

Section: Mock Modelsmentioning

confidence: 99%

Introducing a hardware-in-the-loop simulation of the cardiovascular system

Alazmani

Keeling

Walker

et al. 2012

2012 4th IEEE RAS &Amp; EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob)

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Advances in direct mechanical ventricular actuation devices have been limited by the inability to test the whole device interaction in-vitro. In this study, we introduce a novel technique to produce a realistic, multimodality cardiovascular simulator to mimic the activity of a beating heart. To achieve the mechanical representation of the heart, each ventricle was defined by a real-time modifiable semicircular pattern of post-buckled spring steel strips with adjustable boundary attachments. The mechanical properties of these strips such as stiffness, length, width and boundary conditions approximated the local and global biomechanical properties of the native heart. This physical heart model interfaced with a mathematical model of the cardiovascular system based on hardware-in-the-loop simulation. In-vitro experiments were carried out in an attempt to investigate into the effect that the DMVA system has on PV loop, cardiac output, and overall hemodynamics under different physiological conditions. By employing this in-vitro setting, assist devices can be physically applied to the circulatory models and assessed before animal or clinical trials are conducted. This will significantly aid device behavioural understanding, development time and cost during device's prototyping.

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Section: Mock Modelsmentioning

confidence: 99%

Introducing a hardware-in-the-loop simulation of the cardiovascular system

Alazmani

Keeling

Walker

et al. 2012

2012 4th IEEE RAS &Amp; EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob)

View full text Add to dashboard Cite

show abstract

“…During the peak forward-flow phase, the flow rate in the ascending aorta can reach 500 mL/s [12]. Hydraulic Pump (6) Sequence Valve (7) Rotary Actuator (9) The scaled results of the In a normal adult, the blood pressure 80 mmHg and 120 mmHg over a cardiac cycle, following the same curve and as those presented in Fig. Each component is numbered according to its identification in Fig.…”

Section: Reference Cardiac Conditionmentioning

confidence: 99%

Mechanical simulation model of the systemic circulation

et al. 2015

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“…They are also useful to study heart valves (Scharfscherdt et al 2009) in the aortic (Kuehnel et al 2005), mitral (Jimenez et al 2005) and pulmonary (Gohean et al 2006) positions, as well as being used as ''bioreactors'' for bioengineering tissue valves (Bowles et al 2010;Dumont et al 2002). Finally, mock loops are an extremely effective teaching tool (Pantalos et al 2010;Zannoli et al 2009).…”

Section: In Vitro Modelingmentioning

confidence: 99%