Mechanical shear flow regulates the malignancy of colorectal cancer cells
Yu‐Ting Tseng,
Ching‐Chung Tsai,
Ping‐Chen Chen
et al.
Abstract:Colorectal cancer (CRC) is notable for its high mortality and high metastatic characteristics. The shear force generated by bloodstream provides mechanical signals regulating multiple responses of cells, including metastatic cancer cells, dispersing in blood vessels. We, therefore, studied the effect of shear flow on circulating CRC cells in the present study. The CRC cell line SW620 was subjected to shear flow of 12.5 dynes/cm2 for 1 and 2 h separately. Resulting elevated caspase‐9 and ‐3 indicated that shear… Show more
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