Mechanical Reinforcement of Low‐Concentration Alginate Fibers by Microfluidic Embedding of Multiple Cores

Yoon, Dong Hyun; Tanaka, Daiki; Sekiguchi, Tetsushi; Shoji, Shuichi

doi:10.1002/mame.201700516

Cited by 6 publications

(4 citation statements)

References 38 publications

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“…This unique property enables the preparation of alginate textile fibres through a wet-spinning process, using SA as the spinning solution and divalent metal salt solutions as the coagulant [6,7]. Alginate textile fibres, which are important supplements for natural and modified textile fibres, such as cotton, wool, silk, and modified cellulose, are biocompatible, biodegradable, inexpensive, easy to prepare and can be widely used to make clothes, decoration materials and disposable non-woven medical fabrics [8]. Because land resources are currently being exhausted, the investigation and utilization of ocean-based alginate fibres are of great significance.…”

Section: Introductionmentioning

confidence: 99%

Preparation of CdTe/Alginate Textile Fibres with Controllable Fluorescence Emission through a Wet-Spinning Process and Application in the Trace Detection of Hg2+ Ions

et al. 2019

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Fluorescent textile fibres (FTFs) are widely used in many industrial fields. However, in addition to fibres with good fluorescence, fibres with excellent colour controllability, structural stability and appropriate mechanical strength still need to be developed. In this work, CdTe/alginate composite FTFs are prepared by taking advantage of the interactions between CdTe nanocrystals (NCs) and alginate macromolecules via a wet-spinning machine with a CaCl2 aqueous solution as the coagulation bath. CdTe NCs were chemically fixed in the fibre due to the interactions among surface ligands, macromolecules and coagulators (calcium ions), which ensured the excellent dispersity and good stability of the fibres. Förster resonance energy transfer (FRET) between NCs in the fibre was found to be restricted, which means that the emission colour of the fibres was totally controllable and could be predicted. Other properties of alginate fibres, such as flame retardance and mechanical strength, were also well preserved in the fluorescent fibres. Finally, FTFs showed good selectivity toward trace Hg2+ ions over other metallic ions, and the detection could be identified by the naked eye.

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Section: Introductionmentioning

confidence: 99%

Preparation of CdTe/Alginate Textile Fibres with Controllable Fluorescence Emission through a Wet-Spinning Process and Application in the Trace Detection of Hg2+ Ions

et al. 2019

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“…An analogical approach has been later also used to generate core–shell fibers with hollow subcompartments ( Figure 14 C), resulting in fibers with cross-sectional tunable flower-like morphology. 357 Merging of up to four different alginate streams has been also demonstrated 80 via 3D coflow in a three-layer device, resulting in Janus fibers with compartments aligned side-by-side or forming a pie-chart-like pattern with up to four different compartments ( Figure 14 D). Yet another approach has exploited integration of multiple streams in-plane, 69 resulting in alginate structures intermediate between a fiber and a ribbon, with up to 11 parallel compartments including hollow sections ( Figure 14 E).…”

Section: Microfluidic Strategies Of Formulation Of Compartmentalized ...mentioning

confidence: 96%

“…An analogical approach has been later also used to generate core–shell fibers with hollow subcompartments (Figure C), resulting in fibers with cross-sectional tunable flower-like morphology . Merging of up to four different alginate streams has been also demonstrated via 3D coflow in a three-layer device, resulting in Janus fibers with compartments aligned side-by-side or forming a pie-chart-like pattern with up to four different compartments (Figure D).…”

Section: Microfluidic Strategies Of Formulation Of Compartmentalized ...mentioning

confidence: 99%

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Microfluidic Formulation of Topological Hydrogels for Microtissue Engineering

et al. 2022

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Microfluidics has recently emerged as a powerful tool in generation of submillimeter-sized cell aggregates capable of performing tissue-specific functions, so-called microtissues, for applications in drug testing, regenerative medicine, and cell therapies. In this work, we review the most recent advances in the field, with particular focus on the formulation of cell-encapsulating microgels of small "dimensionalities": "0D" (particles), "1D" (fibers), "2D" (sheets), etc., and with nontrivial internal topologies, typically consisting of multiple compartments loaded with different types of cells and/or biopolymers. Such structures, which we refer to as topological hydrogels or topological microgels (examples including core− shell or Janus microbeads and microfibers, hollow or porous microstructures, or granular hydrogels) can be precisely tailored with high reproducibility and throughput by using microfluidics and used to provide controlled "initial conditions" for cell proliferation and maturation into functional tissue-like microstructures. Microfluidic methods of formulation of topological biomaterials have enabled significant progress in engineering of miniature tissues and organs, such as pancreas, liver, muscle, bone, heart, neural tissue, or vasculature, as well as in fabrication of tailored microenvironments for stem-cell expansion and differentiation, or in cancer modeling, including generation of vascularized tumors for personalized drug testing. We review the available microfluidic fabrication methods by exploiting various cross-linking mechanisms and various routes toward compartmentalization and critically discuss the available tissue-specific applications. Finally, we list the remaining challenges such as simplification of the microfluidic workflow for its widespread use in biomedical research, bench-to-bedside transition including production upscaling, further in vivo validation, generation of more precise organ-like models, as well as incorporation of induced pluripotent stem cells as a step toward clinical applications.

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Multifunctional Micro/Nanoscale Fibers Based on Microfluidic Spinning Technology

2019

Advanced Materials

187

174

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Superfine multifunctional micro/nanoscale fibrous materials with high surface area and ordered structure have attracted intensive attention for widespread applications in recent years. Microfluidic spinning technology (MST) has emerged as a powerful and versatile platform because of its various advantages such as high surface‐area‐to‐volume ratio, effective heat transfer, and enhanced reaction rate. The resultant well‐defined micro/nanoscale fibers exhibit controllable compositions, advanced structures, and new physical/chemical properties. The latest developments and achievements in microfluidic spun fiber materials are summarized in terms of the underlying preparation principles, geometric configurations, and functionalization. Variously architected structures and shapes by MST, including cylindrical, grooved, flat, anisotropic, hollow, core–shell, Janus, heterogeneous, helical, and knotted fibers, are emphasized. In particular, fiber‐spinning chemistry in MST for achieving functionalization of fiber materials by in situ chemical reactions inside fibers is introduced. Additionally, the applications of the fabricated functional fibers are highlighted in sensors, microactuators, photoelectric devices, flexible electronics, tissue engineering, drug delivery, and water collection. Finally, recent progress, challenges, and future perspectives are discussed.

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Mechanical Reinforcement of Low‐Concentration Alginate Fibers by Microfluidic Embedding of Multiple Cores

Cited by 6 publications

References 38 publications

Preparation of CdTe/Alginate Textile Fibres with Controllable Fluorescence Emission through a Wet-Spinning Process and Application in the Trace Detection of Hg2+ Ions

Preparation of CdTe/Alginate Textile Fibres with Controllable Fluorescence Emission through a Wet-Spinning Process and Application in the Trace Detection of Hg2+ Ions

Microfluidic Formulation of Topological Hydrogels for Microtissue Engineering

Multifunctional Micro/Nanoscale Fibers Based on Microfluidic Spinning Technology

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