Mechanical reinforcement of electrospun water-soluble polymer nanofibers using nanodiamonds

Wang, Zelong; Cai, Ning; Zhao, Dongpeng; Xu, Jia; Dai, Qin; Xue, Yanan; Luo, Xiaogang; Yuan, Ye; Yu, Faquan

doi:10.1002/pc.22577

Cited by 41 publications

(30 citation statements)

References 50 publications

(54 reference statements)

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“…Following the addition of nanofillers, polymer chain may interact with the fillers through intermolecular attractions, such as van der Waals force and hydrogen bonding [34]. Thus, the mobility of the polymer chain segment in the vicinity of the nanofiller surface may be inhibited by the inorganics [35].…”

Section: Resultsmentioning

confidence: 99%

“…Good particle-matrix interfacial adhesion cannot form in aggregative nanotubes, which impairs the effective load transfer from the polymer matrix to the fillers. Thus, these aggregates act as defects, resulting in degraded mechanical performance [35]. In the results of DSC, 4 wt% is deduced to be the critical concentration to judge whether the dispersion of HNTs is aggravated.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

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Toughening of electrospun poly(l-lactic acid) nanofiber scaffolds with unidirectionally aligned halloysite nanotubes

et al. 2014

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The mechanical properties of the tissue engineering scaffold are important as they are tightly related the regeneration of structural tissue. The application of poly(L-lactic acid) (PLLA) nanofiber scaffolds in tissue engineering has been hindered by their insufficient mechanical properties. In the study, halloysite nanotubes (HNTs) were used to reinforce the mechanical properties of PLLA-based nanofibers. 4 wt% HNT/PLLA nanofiber membranes possess the best mechanical performance, which represents 61 % increase in tensile strength, 100 % improvement of Young's modulus, 49 % augment of elongation to break, as well as 181 % elevation in energy to break compared with neat PLLA samples. The satisfactory enhancement effect of HNTs can be attributed to the effective dispersion and incorporation of HNTs in PLLA matrix, which have been confirmed by the analysis of SEM, TEM, and FTIR. The addition of HNTs also improves the degree of crystallization and thermal stability of PLLA-based nanofibers. HNT-incorporated PLLA nanofiber membranes possess higher protein adsorption from fetal bovine serum than the neat PLLA specimen. Therefore, the introduction of HNTs can effectively enhance the mechanical properties of PLLA nanofiber scaffolds. HNT/PLLA nanofiber scaffolds possess potential application in skin tissue engineering.

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Section: Resultsmentioning

confidence: 99%

Section: Mechanical Propertiesmentioning

confidence: 99%

Toughening of electrospun poly(l-lactic acid) nanofiber scaffolds with unidirectionally aligned halloysite nanotubes

et al. 2014

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“…Hence, they can reinforce the mechanical properties of polymers thereby creating multifunctional nanocomposites for bone regenerative applications [17][18][19]. To fully benefit from the advantages of ND as nanofiller, the quality of the dispersion in the matrix must be addressed first since it determines the surface area of the nanoparticles available for interaction with the matrix and ultimately translates into mechanical properties of the resulting composite.…”

Section: Nds As Nanofillersmentioning

confidence: 99%

Adoption of nanodiamonds as biomedical materials for bone repair

et al. 2017

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Keywords: gene/drug delivery • nanodiamonds • therapeutics Nanodiamonds (NDs) are an emerging class of biologically compatible carbon-based nanomaterials that possess a set of unique properties essential for the design of innovative therapies in the fields of drug delivery, tissue engineering and bioimaging [1]. For instance, the high surface area along with the tunable surface chemistry enables the physical adsorption or covalent conjugation of a variety of therapeutic molecules, such as drugs, peptides and growth factors [2][3][4][5]. Additionally, NDs' surface can be modified with targeting biological signals to achieve a selective cellular internalization of chemotherapeutic agents as well as genetic materials. Aside from their role as carriers in drug and gene delivery, NDs have been widely explored as nanofillers to improve the physical and mechanical properties of both natural and synthetic scaffolds [6,7]. Specifically, NDs have found application in the field of bone tissue engineering as reinforcing nanomaterial to design nanocomposite systems necessary to promote bone regeneration. This editorial emphasizes on the current state-of-the-art research using NDs in the field of bone repair, with a focus on the recent breakthroughs such as precise immobilization of growth factors and peptides. Biomolecule immobilization via surface functionalization of NDsNDs are carbon-based nanomaterials, which possess a set of unique properties that enables their use in a variety of applications including drug delivery, tissue engineering and bioimaging. This advantage has encouraged scientists to investigate NDs for a broad range of applications [8] in regenerative medicine with a primary focus on bone tissue engineering. NDs possess versatile surface functionalities and they can be loaded with virtually any type of biomolecule, thereby enabling their use as delivery vehicles in bone-healing applications [9]. The presence of surface functional groups can efficiently control the interfacial reactions between the nanoparticle and the active biomolecule, eventually maximizing the therapeutic efficiency of the delivered biomaterial. The initial functional groups present on the surface of NDs, following the formation of the nanoparticle, vary according to the selected synthesis and purification methods. For example, hydrogen-assisted chemical vapor deposition generates NDs bearing hydrogen-terminated surfaces. On the other hand, methods, such as detonation synthesis, introduce a highly diverse surface chemistry, with functional groups such as hydroxyl, carbonyl, ether and carboxyl groups. It is essential to maintain a similar functionality throughout the entire surface to enable further surface reactions. Thus, chemical treatment of the NDs is often required to create homogenized reactive surfaces. Among the possible alternatives, carboxylation, hydroxylation or hydrogenation are the commonly investigated routes to generate -COOH and -OH groups on the surface. Due to the presence of these diverse functionalities on the surfac...

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“…Due to their target specificity, anti-bacterial properties and small size, they are primarily used as carriers for: chemotherapeutic anticancerous agents and anti-bacterial drugs. 14,[19][20][21] , growth factors such as bone morphogenic protein 2 (BMP 2) and fibroblast growth factor (FGF) 22 , and DNA for gene therapy 23 .…”

Section: Accepted Version Science Of Advanced Materialsmentioning

confidence: 99%

Dental Applications of Nanodiamonds

Najeeb¹,

Khurshid²,

Agwan³

et al. 2016

sci adv mater

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Nanodiamonds (NDs) have been used in various fields of medicine such as drug delivery, tissue regeneration and gene therapy. Although there has been research carried out investigated the potential of these remarkable materials in dentistry, to date no review has been published to summarize the studies conducted.Due to their target cell specificity, small size and fluorescence they have also been found to be usefulness in dentistry. Main applications of NDs in dentistry and medicine include guided tissue regeneration, reinforcement of polymers and drug delivery to treat infections and cancers. Recent research also suggests that NDs can also be used as bioactive or antibacterial dental implant coatings. However, to date, the research conducted on their biocompatibility is limited and inconclusive. Hence, substantially more in vitro and in vivo studies are required to envisage the future of NDs in dentistry. It is hoped that in the next decade these promising materials will find a variety of uses in routine dentistry.

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Mechanical reinforcement of electrospun water-soluble polymer nanofibers using nanodiamonds

Cited by 41 publications

References 50 publications

Toughening of electrospun poly(l-lactic acid) nanofiber scaffolds with unidirectionally aligned halloysite nanotubes

Toughening of electrospun poly(l-lactic acid) nanofiber scaffolds with unidirectionally aligned halloysite nanotubes

Adoption of nanodiamonds as biomedical materials for bone repair

Dental Applications of Nanodiamonds

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