Mechanical regulation of bone regeneration during distraction osteogenesis

Fu, Ruisen; Feng, Yixiang; Liu, Youjun; Yang, Haisheng

doi:10.1016/j.medntd.2021.100077

Cited by 10 publications

(9 citation statements)

References 85 publications

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“…The reconstruction of bone defects with bio-substitute scaffolds that finely fit the natural bone tissue is a highly attractive approach clinically. 1–6 Bone, as an important product of mineralization in the body, 7–9 is an organic–inorganic composite with hierarchical structures across different scales. 1,10–12 Mineralization is the key for the formation of a mechanical adaptive hierarchical structure of bone and for the production of bio-substitute scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Orthophosphate and alkaline phosphatase induced the formation of apatite with different multilayered structures and mineralization balance

Niu

Jia

et al. 2022

Nanoscale

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Section: Introductionmentioning

confidence: 99%

Orthophosphate and alkaline phosphatase induced the formation of apatite with different multilayered structures and mineralization balance

Niu

Jia

et al. 2022

Nanoscale

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Section: Introductionmentioning

confidence: 99%

“…DO is a mechanobiological process which involves producing new bone and overlying soft tissues through the gradual and controlled distraction of surgically separated bone segments [6][7][8]. DO consists of three consecutive phases: latency, distraction, and consolidation phases [6,9]. The process of bone regeneration during DO is regulated by mechanical stimuli; therefore, the healing outcomes are largely affected by distraction parameters such as the distraction rate and frequency [6,[9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…DO consists of three consecutive phases: latency, distraction, and consolidation phases [6,9]. The process of bone regeneration during DO is regulated by mechanical stimuli; therefore, the healing outcomes are largely affected by distraction parameters such as the distraction rate and frequency [6,[9][10][11]. One important mechanical parameter is the distraction rate (i.e., the distance over which the bone is lengthened per day) [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…However, for clinical cases where lengthening exceeds 5 cm, distractions of 1 mm/day are associated with a prolonged treatment period, leading to various complications and increased numbers of revision surgeries [14,15]. Therefore, there remains a critical need to optimize the distraction parameters to shorten the distraction time and improve the efficiency of DO [6].…”

Section: Introductionmentioning

confidence: 99%

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Enhancing the Efficiency of Distraction Osteogenesis through Rate-Varying Distraction: A Computational Study

Feng

Bertrand

et al. 2021

IJMS

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Distraction osteogenesis (DO) is a mechanobiological process of producing new bone and overlying soft tissues through the gradual and controlled distraction of surgically separated bone segments. The process of bone regeneration during DO is largely affected by distraction parameters. In the present study, a distraction strategy with varying distraction rates (i.e., “rate-varying distraction”) is proposed, with the aim of shortening the distraction time and improving the efficiency of DO. We hypothesized that faster and better healing can be achieved with rate-varying distractions, as compared with constant-rate distractions. A computational model incorporating the viscoelastic behaviors of the callus tissues and the mechano-regulatory tissue differentiation laws was developed and validated to predict the bone regeneration process during DO. The effect of rate-varying distraction on the healing outcomes (bony bridging time and bone formation) was examined. Compared to the constant low-rate distraction, a low-to-high rate-varying distraction provided a favorable mechanical environment for angiogenesis and bone tissue differentiation, throughout the distraction and consolidation phase, leading to an improved healing outcome with a shortened healing time. These results suggest that a rate-varying clinical strategy could reduce the overall treatment time of DO and decrease the risk of complications related to the external fixator.

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Management of proximal femur malunion and distal femur nonunion via proximal femoral nailing and free fibular graft: A case report

Kalantar,

Bagheri,

Beheshti Fard

et al. 2023

International Journal of Surgery Case Reports

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Mechanical regulation of bone regeneration during distraction osteogenesis

Cited by 10 publications

References 85 publications

Orthophosphate and alkaline phosphatase induced the formation of apatite with different multilayered structures and mineralization balance

Orthophosphate and alkaline phosphatase induced the formation of apatite with different multilayered structures and mineralization balance

Enhancing the Efficiency of Distraction Osteogenesis through Rate-Varying Distraction: A Computational Study

Management of proximal femur malunion and distal femur nonunion via proximal femoral nailing and free fibular graft: A case report

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