Mechanical Property Changes of Barium Titanate (Ceramic) After in Vivo and in Vitro Aging

Abstract

Since barium titanate (BaTi03) can be made piezoelectric, it may be used to substitute hard tissues directly. As a first step in testing this concept, a series of in vivo and in vitro aging and biocompatibility studies were performed. The mean compressive strength of samples implanted subcutaneously in the backs of rabbits decreased to 138 MPa after 20 weeks from a control value of 281 MPa. Similar, though less drastic losses of strength were seen when specimens were aged in distilled water (182 MPa at 28 weeks) and Ringer's solution (159 MPa at 28 weeks). The most rapid decrease of strength in all cases was seen prior to 4 weeks. Thereafter, the decrease was much slower. Histological evaluation of the tissue surrounding the implant revealed a thin fibrous capsule and no evidence of tissue inflammation.

Multifunctional Properties of Multistage Spark Plasma Sintered HA–BaTiO3‐Based Piezobiocomposites for Bone Replacement Applications

“…A careful consideration of every aspect (biocompatibility, mechanical, and electrical) of the bone analogue material with that of the natural bone can comprehensively improve the performance of implants. At this juncture, the perovskite BaTiO 3 (BT) can be a promising material as it is proved to be in vitro and in vivo biocompatible . Also, due to piezoelectricity, the addition of BT as a secondary phase has been demonstrated to improve the mechanical properties in a number of composite systems .…”

In vitro/In vivo assessment and mechanisms of toxicity of bioceramic materials and its wear particulates

“…Among the various HA-BaTiO 3 composites developed by our group, HA-40 wt% BaTiO 3 showed mechanical and electrical properties similar to bone. Although the biocompatibility of BaTiO 3 has been proved by several studies in both hard and so tissues, 181,182 the presence of Ba in the composite still raises concerns on the potential toxicity, if used as a long term implant. In view of this, HA-40 wt% BaTiO 3 nanoparticulates were evaluated both in vitro using myoblasts cells and in vivo, by injecting at the articular joints of mice.…”

Capacitive Feedthroughs for Medical Implants

“…The most suitable material for the concept seems to be barium titanate, as it shows the highest relative permittivity and also a great biocompatibility in in-vitro (Park et al, 1977; Beloti et al, 2006; Zhang et al, 2014) and in-vivo studies (Park et al, 1977, 1981; Lopes et al, 2013). Also conceivable would be the use of titanium dioxide, which has a well-known and well-tested biocompatibility, and a relative permittivity of around 110.…”