Mechanical Properties of Reversibly Cross-Linked Ultrathin Polyelectrolyte Complexes

Jaber, Jad A.; Schlenoff, Joseph B.

doi:10.1021/ja055892n

Cited by 138 publications

(243 citation statements)

References 83 publications

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“…27 The PEM must provide a mechanical support for LSEC culture, a physical barrier between hepatocytes and LSECs, but most importantly allow diffusion of signaling molecules to facilitate cell-cell communication and phenotypic maintenance of both cell types. Recent efforts to create free standing PEMs comprised of synthetic and biologically derived PEs 18,140,141 exhibit tremendous potential to be utilized as scaffolds in tissue engineering. An application with much potential in biological therapeutic applications is the coating of individual cells with biocompatible PEMs.…”

Section: Conclusion and Future Possibilitiesmentioning

confidence: 99%

Polyelectrolyte Multilayers in Tissue Engineering

Detzel

Larkin

Rajagopalan

2011

Tissue Engineering Part B: Reviews

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The layer-by-layer assembly of sequentially adsorbed, alternating polyelectrolytes has become increasingly important over the past two decades. The ease and versatility in assembling polyelectrolyte multilayers (PEMs) has resulted in numerous wide ranging applications of these materials. More recently, PEMs are being used in biological applications ranging from biomaterials, tissue engineering, regenerative medicine, and drug delivery. The ability to manipulate the chemical, physical, surface, and topographical properties of these multilayer architectures by simply changing the pH, ionic strength, thickness, and postassembly modifications render them highly suitable to probe the effects of external stimuli on cellular responsiveness. In the field of regenerative medicine, the ability to sequester growth factors and to tether peptides to PEMs has been exploited to direct the lineage of progenitor cells and to subsequently maintain a desired phenotype. Additional novel applications include the use of PEMs in the assembly of three-dimensional layered architectures and as coatings for individual cells to deliver tunable payloads of drugs or bioactive molecules. This review focuses on literature related to the modulation of chemical and physical properties of PEMs for tissue engineering applications and recent research efforts in maintaining and directing cellular phenotype in stem cell differentiation.

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Section: Conclusion and Future Possibilitiesmentioning

confidence: 99%

Polyelectrolyte Multilayers in Tissue Engineering

Detzel

Larkin

Rajagopalan

2011

Tissue Engineering Part B: Reviews

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“…5 Many researchers have investigated freestanding LBL films. [6][7][8] However, the LBL ultrathin film breaks or decomposes easily during the application, which is one of the main shortages that hampers the application of the materials. 9 Covalent assembly is an effective strategy for improving the physical or chemical properties of the LBL films.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of covalently bonded PVA/Laponite/HAPI nanocomposite multilayer freestanding films by layer‐by‐layer assembly

Ren

Guo

et al. 2015

J Polym Sci B Polym Phys

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The layer-by-layer (LBL) assembly technique is an attractive method to make functional multilayer thin films and has been applied to fabricate a wide range of materials. LBL materials could improve optical transmittance and mechanical properties if the film components were covalently bonded. Covalently bonded nanocomposite multilayer films were prepared by employing hydrophilic aliphatic polyisocyanate (HAPI) as the reactive component, to react with Laponite and polyvinyl alcohol (PVA). FT-IR spectra suggested that HAPI reacted with Laponite and PVA at ambient temperature rapidly. Ellipsometry measurement showed that the film thickness was in linear growth. The influences of HAPI on the optical, mechanical and thermal properties of the films were investigated by UV-Vis spectroscopy, tensile stress measurement, DSC and TGA. The obtained results showed that the optical transmittance and mechanical strength were enhanced when the film components were covalently bonded by HAPI. V C 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2015, 00, 000-000 KEYWORDS: covalently bonded; layer-by-layer; nanocomposites; self-assembly; thin films INTRODUCTION The layer-by-layer (LBL) assembly technique is an attractive method to make functional multilayer thin films and has been applied in the fabrication of nanodevice, drug release, and biomimetic materials.1-4 LBL multilayer films are more versatile in many aspects than bulk materials because they have more precisely controlled composition and structure at nanoscale dimensions. 5 Many researchers have investigated freestanding LBL films.6-8 However, the LBL ultrathin film breaks or decomposes easily during the application, which is one of the main shortages that hampers the application of the materials.9 Covalent assembly is an effective strategy for improving the physical or chemical properties of the LBL films.10-12 Another approach is achieved by introducing inorganic materials such as Laponite, montmorillonite and carbon nanotube into the LBL multilayer films. [13][14][15][16] Researchers have employed hydrogen bond, dipolar bond, or electrostatic attraction between polymer and inorganic particles to fabricate nanocomposite LBL multilayer films. 17,18 This type of physical interaction, however, often leads to unstable multilayer films in strong acid, strong alkali or high humidity conditions.

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“…Another strategy for stiffening the polyelectrolyte multilayer films is to modify their internal composition and structure. According to Schlenoff et al, the mechanical properties of the films are strongly influenced by the presence of counterions, which must ensure charge balance within the film [8][9][10]. Multilayer films with extrinsic charge are much softer since counterions break ion pair cross-links between oppositely charged polyelectrolyte pairs [9].…”

Section: Introductionmentioning

confidence: 99%