Mechanical properties of rat thoracic and abdominal aortas

Assoul, Nabila; Flaud, Patrice; Chaouat, Marc; Letourneur, Didier; Bataille, Isabelle

doi:10.1016/j.jbiomech.2008.04.017

Cited by 40 publications

(29 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No statistically significant difference was also observed between native Wistar and both native and decellularized DA aortas, suggesting that the treated DA is a suitable tissue for the in vivo studies in Wistar rats (recipients). Unfortunately, there is a paucity of studies related to the mechanical properties of abdominal rat aorta [29,37]. Previous studies performed on Wistar Kyoto and Lewis rats showed values of collagen phase slope and ultimate tensile strength similar to those reported in the present study for all the test groups [29]; nevertheless, the rat strains and the mechanical testing methods were different.…”

Section: Discussionsupporting

confidence: 65%

Investigation of the Biomechanical Integrity of Decellularized Rat Abdominal Aorta

Katsimpoulas

Morticelli

Michalopoulos

et al. 2015

Transplantation Proceedings

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 65%

Investigation of the Biomechanical Integrity of Decellularized Rat Abdominal Aorta

Katsimpoulas

Morticelli

Michalopoulos

et al. 2015

Transplantation Proceedings

View full text Add to dashboard Cite

“…elderly vs. young). In biomechanics, many investigations are based on animal models [19,21] or imaging methods in vivo [2,4,5], and these have obvious limitations. Only studies with ex vivo aortic specimens allow the direct assessment of biomechanical properties through destructive testing [22].…”

Section: Discussionmentioning

confidence: 99%

Biomechanical Properties and Microstructural Analysis of the Human Nonaneurysmal Aorta as a Function of Age, Gender and Location: An Autopsy Study

et al. 2015

View full text Add to dashboard Cite

Introduction: The biomechanical failure properties and histological composition of the human nonaneurysmal aorta were studied. Methods: Twenty-six human aortas were harvested from fresh cadavers at autopsy. A total of 153 circumferentially oriented strips were obtained from the aortas for biomechanical and histological studies. Results: The failure load (6.18 ± 2.03 vs. 4.85 ± 2.04 N; p = 0.001), failure tension (19.88 ± 9.05 vs. 14.53 ± 7 N/cm; p = 0.001), failure strain (0.66 ± 0.31 vs. 0.49 ± 0.25; p = 0.003) and amount of elastic fibers (19.39 ± 15.57 vs. 14.06 ± 9.5%; p = 0.011) were all significantly higher for the thoracic than the abdominal aorta. There was a significant negative correlation between age and failure load (R = -0.35; p < 0.0001), failure stress (R = -0.63; p < 0.0001), failure tension (R = -0.52; p < 0.0001) and failure strain (R = -0.8; p < 0.0001). Male aortas had a higher failure load and failure tension than female aortas. Conclusion: The thoracic aorta has a higher strength and elasticity than the abdominal aorta. The elderly have weaker and stiffer aortas than the young. Male aortas are stronger than female aortas.

show abstract

“…For example, it has been shown that the kidney vascular tree consists of 10 – 12 branching orders and includes 10,000 segments [30]. Organospecific organization of vascular trees in human organs is the subject of intensive ongoing research [33–39]. Classical anatomical techniques such as corrosion casts have been combined with high-resolution scanning electron microscopy [40,41].…”

Section: Designing the Intra-organ Vascular Treementioning

confidence: 99%

Towards organ printing: engineering an intra-organ branched vascular tree

Visconti

Kasyanov

Gentile

et al. 2010

Expert Opinion on Biological Therapy

208

142

View full text Add to dashboard Cite

Importance of the field Effective vascularization of thick three-dimensional engineered tissue constructs is a problem in tissue engineering. As in native organs, a tissue-engineered intra-organ vascular tree must be comprised of a network of hierarchically branched vascular segments. Despite this requirement, current tissue-engineering efforts are still focused predominantly on engineering either large-diameter macrovessels or microvascular networks. Areas covered in this review We present the emerging concept of organ printing or robotic additive biofabrication of an intra-organ branched vascular tree, based on the ability of vascular tissue spheroids to undergo self-assembly. What the reader will gain The feasibility and challenges of this robotic biofabrication approach to intra-organ vascularization for tissue engineering based on organ-printing technology using self-assembling vascular tissue spheroids including clinically relevantly vascular cell sources are analyzed. Take home message It is not possible to engineer 3D thick tissue or organ constructs without effective vascularization. An effective intra-organ vascular system cannot be built by the simple connection of large-diameter vessels and microvessels. Successful engineering of functional human organs suitable for surgical implantation will require concomitant engineering of a ‘built in’ intra-organ branched vascular system. Organ printing enables biofabrication of human organ constructs with a ‘built in’ intra-organ branched vascular tree.

show abstract

Mechanical properties of rat thoracic and abdominal aortas

Cited by 40 publications

References 37 publications

Investigation of the Biomechanical Integrity of Decellularized Rat Abdominal Aorta

Investigation of the Biomechanical Integrity of Decellularized Rat Abdominal Aorta

Biomechanical Properties and Microstructural Analysis of the Human Nonaneurysmal Aorta as a Function of Age, Gender and Location: An Autopsy Study

Towards organ printing: engineering an intra-organ branched vascular tree

Contact Info

Product

Resources

About