Mechanical properties of micro- and nanocapsules: Single-capsule measurements

Fery, Andreas; Weinkamer, Richard

doi:10.1016/j.polymer.2007.07.050

Cited by 240 publications

(205 citation statements)

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“…11,12 In particular, a colloidal probe (CP) technique offers a valuable means of studying particle mechanics on a single particle level as well as surface interaction forces. [13][14][15] In biological investigations CP-AFM is even employed to analyze the stiffness and deformation behavior of entire cells. 16 Here, we investigated the swelling behavior of dried eADF4-(C16) particles upon hydration and their mechanical properties in the dry and wet state.…”

Section: Introductionmentioning

confidence: 99%

Micromechanical characterization of spider silk particles

Neubauer

Blüm

Agostini³

et al. 2013

Biomater. Sci.

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a Spider silk fibers are well known for their mechanical properties, and they are therefore in the focus of materials scientists. Additionally, silks display biocompatibility making them interesting materials for applications in medicine or cosmetics. Due to the low abundance of natural spider silk proteins because of the spider's cannibalism, the recombinant spider silk protein eADF4 has been established for material science applications. Once processed into micron-sized particles by controlled salting-out, these particles can be used as drug delivery vehicles. For any application of the silk particles it is important to know their mechanical characteristics for processing and storage reasons. Here, we examine the swelling behavior and mechanics of these particles. Upon hydration, a drastic drop in elastic modulus occurs by orders of magnitude, from 0.8 GPa in the dry state to 2.99 MPa in the wet state. Importantly, the elastic modulus of recombinant silk particles can be tuned by varying the molecular weight of the used proteins, as well as chemical crosslinking thereof.

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Section: Introductionmentioning

confidence: 99%

Micromechanical characterization of spider silk particles

Neubauer

Blüm

Agostini³

et al. 2013

Biomater. Sci.

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“…The slope (k mem ) is plotted as a function of pH and shown in Figure 2b. According to the shell deformation theory, the slope of the load-deformation curve represents the stiffness of the vesicle membrane (k mem ), which is expressed as [17] :…”

Section: Resultsmentioning

confidence: 99%

“…Materials PS 139 -b-PAA 17 (subscripts denote the number of repeat units for the respective blocks) was purchased from Polymer Source, Inc. 3-Aminopropyltrimethoxysilane, sodium hydroxide (NaOH, 0.1 M) and hydrochloric acid (HCl, 0.1 M) were purchased from SigmaAldrich, Inc. Tetrahydrofuran (THF, AR grade) was purchased from Biosolve B. V. Milli-Q water was produced by a Millipore Synergy system. All chemicals were used as received.…”

Section: Methodsmentioning

confidence: 99%

pH Dependent Elasticity of Polystyrene‐block‐poly(acrylic acid) Vesicle Shell Membranes by Atomic Force Microscopy

Chen

Vancso

2011

Macromol. Rapid Commun.

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We assess the elastic properties of PS-b-PAA vesicle membranes under different pH values by AFM force measurements. We find that based on the shell deformation theory, the values of the estimated apparent Young's modulus of the vesicle membranes decrease as the pH of the solution increases. The onset of the decrease of E coincides with the surface pK(a) determined from ζ-potential measurements. This decrease of E at higher pH is attributed to electrostatic repulsion between the deprotonated PAA chains resulting in the thinning of the vesicle membrane.

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“…Mechanical properties are fundamentally important because they determine capsule stability and integrity. Design of mechanically stable capsules is of high interest since they are typically deformed upon intracellular uptake, [76], [77] leading to losses in the amount of delivered material. A new method consisting in release upon mechanical deformation of polyelectrolyte multilayer capsules has been developed by combining fluorescence microscopy with AFM force spectroscopy.…”

Section: Release From Polyelectrolyte Multilayer Capsules In Solutionmentioning

confidence: 99%