Mechanical properties of l-lysine based segmented polyurethane vascular grafts and their shape memory potential

Castillo-Cruz, O.; Avilés, F.; Vargas-Coronado, Rossana Faride; Cauich-Rodríguez, Juan Valerio; Chan-Chan, Lerma H.; Sessini, Valentina; Peponi, Laura

doi:10.1016/j.msec.2019.04.073

Cited by 26 publications

(11 citation statements)

References 44 publications

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“…It was observed that the attachment of cells to lysine-modified hydrogel was five times more effective, compared with a poly- l- lysine coating. The interaction between the biomaterial and the cells might occur through electrostatic interaction between the positive charge from –NH 3+ and negatively charged substances on the cell surface such as glycosaminoglycans [ 35 , 36 ]. The synergistic role of l -lysine and hydroxyapatite in osteoblast healing processes was also reported [ 11 ].…”

Section: Resultsmentioning

confidence: 99%

Influence of Hydroxyapatite Surface Functionalization on Thermal and Biological Properties of Poly(l-Lactide)- and Poly(l-Lactide-co-Glycolide)-Based Composites

Gazińska

Krokos

Kobielarz

et al. 2020

IJMS

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Novel biocomposites of poly(L-lactide) (PLLA) and poly(l-lactide-co-glycolide) (PLLGA) with 10 wt.% of surface-modified hydroxyapatite particles, designed for applications in bone tissue engineering, are presented in this paper. The surface of hydroxyapatite (HAP) was modified with polyethylene glycol by using l-lysine as a linker molecule. The modification strategy fulfilled two important goals: improvement of the adhesion between the HAP surface and PLLA and PLLGA matrices, and enhancement of the osteological bioactivity of the composites. The surface modifications of HAP were confirmed by attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), TGA, and elemental composition analysis. The influence of hydroxyapatite surface functionalization on the thermal and in vitro biological properties of PLLA- and PLLGA-based composites was investigated. Due to HAP modification with polyethylene glycol, the glass transition temperature of PLLA was reduced by about 24.5 °C, and melt and cold crystallization abilities were significantly improved. These achievements were scored based on respective shifting of onset of melt and cold crystallization temperatures and 1.6 times higher melt crystallization enthalpy compared with neat PLLA. The results showed that the surface-modified HAP particles were multifunctional and can act as nucleating agents, plasticizers, and bioactive moieties. Moreover, due to the presented surface modification of HAP, the crystallinity degree of PLLA and PLLGA and the polymorphic form of PLLA, the most important factors affecting mechanical properties and degradation behaviors, can be controlled.

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Section: Resultsmentioning

confidence: 99%

Influence of Hydroxyapatite Surface Functionalization on Thermal and Biological Properties of Poly(l-Lactide)- and Poly(l-Lactide-co-Glycolide)-Based Composites

Gazińska

Krokos

Kobielarz

et al. 2020

IJMS

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“…In the soft tissue area in contact with hard tissues, flexibility plays a key role in successful integration, cell adhesion, and proliferation. For that, long and flexible SS based on polyester polycaprolactone (PCL) diol, , polycarbonate (PC) diol, , and/or polyether like PEG or polytetramethylene glycol (PTMG) diol structures have been extensively studied for nonspecific , or specific soft tissue mimicking such as cardiac applications, − cartilage, nerve conduits, − or vessels. − …”

Section: Introductionmentioning

confidence: 99%

Recent Advancements in Polyurethane-based Tissue Engineering

Singh

Paswan

Kumar

et al. 2023

ACS Appl. Bio Mater.

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In tissue engineering, polyurethane-based implants have gained significant traction because of their high compatibility and inertness. The implants therefore show fewer side effects and lasts longer. Also, the mechanical properties can be tuned and morphed into a particular shape, owing to which polyurethanes show immense versatility. In the last 3 years, scientists have devised methods to enhance the strength of and induce dynamic properties in polyurethanes, and these developments offer an immense opportunity to use them in tissue engineering. The focus of this review is on applications of polyurethane implants for biomedical application with detailed analysis of hard tissue implants like bone tissues and soft tissues like cartilage, muscles, skeletal tissues, and blood vessels. The synthetic routes for the preparation of scaffolds have been discussed to gain a better understanding of the issues that arise regarding toxicity. The focus here is also on concerns regarding the biocompatibility of the implants, given that the precursors and byproducts are poisonous.

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“…Sessini et al [64] proposed inducing crystallization in an ethylene-vinyl acetate (EVA)-thermoplastic starch (TPS) system in order to obtain both thermally and humidity-activated shape-memory materials. At the same time, the induced crystallization in the PCL domains of PU was used by Castillo et al [65] to obtain shape-memory materials with potential applications as vascular grafts. In this regard, one of the most recent works based on polyurethane was performed by Nissenbaum et al [66], by combining polycaprolactone-diol (PCL-diol)/2,4,2,6-toluene diisocyante (TDI) and ethylene glycol as a chain extender to obtain SMPU nanofibers by electrospinning.…”

Section: Study Of Smp Structure and Propertiesmentioning

confidence: 99%

Shape-Memory Materials via Electrospinning: A Review

et al. 2022

Self Cite

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This review aims to point out the importance of the synergic effects of two relevant and appealing polymeric issues: electrospun fibers and shape-memory properties. The attention is focused specifically on the design and processing of electrospun polymeric fibers with shape-memory capabilities and their potential application fields. It is shown that this field needs to be explored more from both scientific and industrial points of view; however, very promising results have been obtained up to now in the biomedical field and also as sensors and actuators and in electronics.

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Mechanical properties of l-lysine based segmented polyurethane vascular grafts and their shape memory potential

Cited by 26 publications

References 44 publications

Influence of Hydroxyapatite Surface Functionalization on Thermal and Biological Properties of Poly(l-Lactide)- and Poly(l-Lactide-co-Glycolide)-Based Composites

Influence of Hydroxyapatite Surface Functionalization on Thermal and Biological Properties of Poly(l-Lactide)- and Poly(l-Lactide-co-Glycolide)-Based Composites

Recent Advancements in Polyurethane-based Tissue Engineering

Shape-Memory Materials via Electrospinning: A Review

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