Mechanical Properties of Excised Human Skin

Annaidh, Aisling Ní; Otténio, Melanie; Bruyère-Garnier, Karine; Destrade, Michel; Gilchrist, Michael D.

doi:10.1007/978-3-642-14515-5_255

Cited by 56 publications

(62 citation statements)

References 13 publications

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“…The material described here demonstrated a tensile modulus of 0.5 MPa, which was designed to cover the range of elastic response in normal healthy skin reported in the literature 24,25 . Such elastic recoil behaviour, together with a 250% elastic strain region until fracture demonstrated by this material, are likely design parameters that promote the seamless integration of the XPL at the skin interface, thereby allowing for even extreme ranges of motion while providing the instantaneous recoil that is characteristic of youthful, intact skin.…”

Section: Discussionmentioning

confidence: 99%

“…Uniaxial tensile testing that investigated skin anisotropy with respect to the Langer Lines (topological lines corresponding to structural orientation of collagen fibers in the dermis) at different body locations and orientations reported a linear elastic deformation zone at low strains (up to 10% to 40%) and corresponding elastic moduli ranging from 0.5 MPa to 1.95 MPa, with the resulting fracture strain measured at 140% to 180% 24 . Based on these established skin mechanical properties, the target XPL modulus space was identified at 0.5 MPa to 1.95 MPa, and the elastic strain region was specified to be greater than 180%.…”

Section: Materials Synthesis For Network Architecture That Optimizes Ementioning

confidence: 99%

See 1 more Smart Citation

An elastic second skin

Yu¹,

Kang²,

Akthakul³

et al. 2016

Nature Mater

200

141

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We report the synthesis and application of an elastic, wearable crosslinked polymer layer (XPL) that mimics the properties of normal, youthful skin. XPL is made of a tunable polysiloxane-based material that can be engineered with specific elasticity, contractility, adhesion, tensile strength and occlusivity. XPL can be topically applied, rapidly curing at the skin interface without the need for heat-or light-mediated activation. In a pilot human study, we examined the performance of a prototype XPL that has a tensile modulus matching normal skin responses at low strain (< 40%), and that withstands elongations exceeding 250%, elastically recoiling with minimal strain-energy loss on repeated deformation. The application of XPL to the herniated lower-eyelid fat pads of 12 subjects resulted in an average 2-grade decrease in herniation appearance in a 5-point severity scale. The XPL platform may offer advanced solutions to compromised skin barrier function, pharmaceutical delivery, and wound dressings.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Materials Synthesis For Network Architecture That Optimizes Ementioning

confidence: 99%

An elastic second skin

Yu¹,

Kang²,

Akthakul³

et al. 2016

Nature Mater

200

141

View full text Add to dashboard Cite

show abstract

“…5b, pure PDMS film possessed a tensile Young's modulus, ultimate tensile strength and elongation at break of 1 MPa, 1.8 MPa and 150%, respectively. By comparison, the blue-phase PDA could sustain up to~300% stretch- [41], double network gel (DN gel) [42], poly(N-acryloyl glycinamide) gel (PNAGA gel) [43], polyurethane (PEU gel) [44], polypyrrole-grafted chitosan gel (DCh-Ppy gel) [45], nanocomposite hydrogels (NC gel) [46], hydrophobic association hydrogels (HA gel) [47], bacterial cellulose gel (BC gel) [48] and skin [49][50][51].…”

Section: Resultsmentioning

confidence: 99%

A skin-like stretchable colorimetric temperature sensor

Chen

Yin

et al. 2018

Sci. China Mater.

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“…Based on Bottlang et al [24], the compression force is estimated on a pelvic binder in order to reduce unstable pelvic fracture i.e. 180 N. Displacement was applied on both tips of the pelvic straps during binder-tissue interactions to describe the compressive force of the pelvic binder used.…”

Section: Human Tissue-pccds Interactionmentioning

confidence: 99%

Pressure sores of human tissue damage during pelvic binder compression

Munandar

Huzni

Ismail

et al. 2016

Int. J. Automot. Mech. Eng.

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Pelvic circumferential compression is a device used to reduce injury which inadvertently, cause soft tissue damage. When force is applied excessively to the pelvic binder, tissue is damaged due to prolonged high pressure. Therefore, effect from this interaction between tissue and pelvic binder is an important factor to avoid pressure sores due to human tissue damage. The aim of this study is to investigate the effects of human tissue interaction due to compression of the pelvic binder using a finite element modelling approach. A three-dimensional human pelvic model was developed to simulate pressure distribution on tissue interfaces. The applied loads with two different conditions -dry and wet skin were applied on both tips of the pelvic strap during binder-tissue interaction. The compression load of the pelvic binder was estimated on a pelvic strap in order to reduce pelvic fracture. The compression load was varied substantially between locations as well as between skin conditions. There were two straps on the pelvis. For pelvic strap 1, the pressure on the sacrum and ilium was higher than the pressure measured on pelvic strap 2 while pressure on the anterior area was the same for both pelvic straps. Analysis results showed that the pressure which developed between both tissue and pelvic binder exceeded the recommended pressure i.e. ≥ 9.3 kPa at tissue interfaces. When pressure on tissue interfaces is not controlled, this condition can lead to tissue damage due to prolonged periods of time. Hence, to avoid tissue damage to the pelvic binder a cushion must be introduced to reduce the effect of tissue reaction from the prehospital device. Subsequently, tissue and pelvic binder interaction simulation results were compared with experimental data for validation in the model developed.

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Mechanical Properties of Excised Human Skin

Cited by 56 publications

References 13 publications

An elastic second skin

An elastic second skin

A skin-like stretchable colorimetric temperature sensor

Pressure sores of human tissue damage during pelvic binder compression

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