Mechanical Properties of Dilated Human Ascending Aorta

Okamoto, Ruth J.; Wagenseil, Jessica E.; DeLong, William R.; Peterson, S. J.; Kouchoukos, Nicholas T.; Sundt, Thoralf M.

doi:10.1114/1.1484220

Cited by 181 publications

(198 citation statements)

References 36 publications

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“…Additionally, Pham et al found BAV patients, which have been structurally and mechanically linked to MFS patients (13,14,23), to have significantly more isotropic aortic tissue than other AsAA patients, as also found in MFS patients in the current study (24). Pham also found a trend of age-related thickening in BAV tissue, agreeing with our MFS findings.…”

Section: Aneurysmal Stiffeningsupporting

confidence: 82%

“…Significant effort has been devoted to the investigation of the mechanical properties and pathogenesis of AsAA tissue (7,13,14,(18)(19)(20)(21); however, MFS-specific studies are scarce. A number of in vivo studies on Marfan tissues investigate aortic distensibility, stiffness index, and pulse wave velocity (3,(8)(9)(10)(11)(12), consistently finding increased aortic diameter (12), decreased distensibility (8)(9)(10), and stiffness (8,9,12) in MFS patients compared to age-and gender-matched controls; however, these parameters were not correlated, as also found in our study.…”

Section: In Vivomentioning

confidence: 99%

“…Previous studies have investigated the mechanical and structural properties of MFS thoracic aortic aneurysmal tissue both in vivo and ex vivo, consistently showing a decrease in aortic distensibility, increase of stiffness index, and increase in aortic size with dilation (3,(8)(9)(10)(11)(12)(13)(14)(15). However, in vivo studies are limited to the investigation of the physiological range of pressures and thus are unable to characterize the possibility of adverse events, such as aortic dissection and rupture potential.…”

Section: Introductionmentioning

confidence: 99%

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Biomechanical properties of the thoracic aorta in Marfan patients

Sulejmani¹,

Pokutta-Paskaleva²,

Ziganshin³

et al. 2017

Ann. Cardiothorac. Surg.

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Background: Marfan syndrome (MFS), a genetic disorder of the connective tissue, has been strongly linked to dilation of the thoracic aorta, among other cardiovascular complications. As a result, MFS patients frequently suffer from aortic dissection and rupture, contributing to the high rate of mortality and morbidity among MFS patients. Despite the significant effort devoted to the investigation of mechanical and structural properties of aneurysmal tissue, studies on Marfan aneurysmal biomechanics are scarce. Ex vivo mechanical characterization of MFS aneurysmal tissue can provide a better insight into tissue strength outside the physiologic loading range and serve as a basis for improved risk assessment and failure prediction. Methods:The mechanical and microstructural properties of MFS aneurysmal thoracic aorta (MFS, n=15, 39.5±3.91 years), non-MFS aneurysmal thoracic aorta (TAA, n=8, 52.8±4.9 years), healthy human thoracic aorta (HH, n=8, 75.4±6.1 years), and porcine thoracic aorta (n=10) are investigated. Planar biaxial tensile testing and uniaxial failure testing were utilized to characterize the mechanical and failure properties of the tissue, respectively. Verhoeff-Van Gieson (VVG) and PicroSirius Red stains were utilized to visualize the elastin and collagen fiber architecture, respectively.Results: MFS tissue was found to have age-dependent but diameter-independent mechanical, structural, and morphological properties, also showing extensive elastin fiber degradation. Non-MFS thoracic aneurysmal aorta was thicker and stiffer than age-matched MFS tissue. Moreover, non-MFS thoracic aneurysmal mechanics resembled closely the mechanics of older healthy human tissue. Younger MFS tissue (<40 years) exhibited similar mechanical and structural properties to aged porcine tissue.Conclusions: Both age and aneurysmal presence were found to be factors associated with increased stiffness in aortic tissue, and aortic diameter was not a significant determinant of mechanical property deterioration. Additionally, the presence of MFS was found to induce stiffening of the thoracic aorta, although not to the extent of the non-MFS aneurysm.

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Section: Aneurysmal Stiffeningsupporting

confidence: 82%

Section: In Vivomentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biomechanical properties of the thoracic aorta in Marfan patients

Sulejmani¹,

Pokutta-Paskaleva²,

Ziganshin³

et al. 2017

Ann. Cardiothorac. Surg.

View full text Add to dashboard Cite

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“…Most of the previous work investigating the material symmetry of aorta has been performed on animal tissue or involved uniaxial tensile testing, which is unable to conclusively assess the anisotropic response of this tissue. There has been very little published work involving the biaxial experimentation of human aortic tissue, 45,46 and none for AAA tissue. Biaxial tensile testing of AAA recently completed by our laboratory has demonstrated that aneurysmal formation is associated with an increase in circumferential stiffness (830Ϯ120 N/cm 2 versus 330Ϯ60 N/cm 2 for the AAA and AA, respectively [Pϭ0.03]).…”

Section: Ex Vivo Tensile Testingmentioning

confidence: 99%

Biomechanical Determinants of Abdominal Aortic Aneurysm Rupture

Vorp

Geest

2005

ATVB

227

172

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Abstract-Rupture of abdominal aortic aneurysm (AAA) represents a significant clinical event, having a mortality rate of 90% and being currently ranked as the 13th leading cause of death in the US. The ability to reliably evaluate the susceptibility of a particular AAA to rupture on a case-specific basis could vastly improve the clinical management of these patients. Because AAA rupture represents a mechanical failure of the degenerated aortic wall, biomechanical considerations are important to understand this process and to improve our predictions of its occurrence. Presented here is an overview of research to date related to the biomechanics of AAA rupture. This includes a summary of results related to ex vivo and in vivo mechanical testing, noninvasive AAA wall stress estimations, and potential mechanisms of AAA wall weakening. We conclude with a demonstration of a biomechanics-based approach to predicting AAA rupture on a patient-specific basis, which may ultimately prove to be superior to the widely and currently used maximum diameter criterion. Key Words: abdominal aortic aneurysm Ⅲ biomechanics Ⅲ rupture Ⅲ strength Ⅲ stress A bdominal aortic aneurysm (AAA) is a focal enlargement of the infrarenal aorta, which occurs over a time course of several years. This condition is present in Ϸ2% of the elderly population, with Ϸ150 000 new cases diagnosed each year, and the incidence is increasing. 1,2 If left untreated, AAA will gradually expand until rupture; it is an event that carries a mortality rate of 90% and that is ranked as the 13th most common cause of death in the US. 3 Current AAA repair procedures are expensive and carry significant morbidity and mortality risks.Open repair of AAA is a major surgical procedure that requires patients to be hospitalized typically for 1 week and to recuperate at home for several more weeks. The mean postoperative mortality for elective repair is Ϸ5% and for emergency operations 47% (range 27% to 69%). 4 The major drawback of open repair is the compromised quality of life after surgery because of postoperative pain, the prolonged recovery period, and the high costs associated with both the surgery and the recovery.An alternative approach that avoids the extensive tissue dissection associated with open repair is the minimally invasive endovascular repair procedure. The potential advantages of endovascular AAA repair include reductions in mortality, morbidity, blood loss, hospital stay, intensive careOriginal

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“…In biaxial loading, tissue is stiffer and its nonlinearity is less (Dixon et al, 2003). Therefore, biaxial and planar tests may be good alternatives to reach a better understanding of arterial behavior (Guccione et al, 1991;L'italien et al, 1994;Okamoto et al, 2002;Sun et al, 2003, Lu et al, 2005Criscione et al, 2005). Simulations of tissues mechanical behavior are applicable for diagnostic and treatment purposes as well as in surgery (Dumoulin & Cochelin, 2000;Gourisankaran & Sharma, 2000;Laroche & Delorme, 2006;Kiousis et al, 2007;Wu et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Determining the biomechanical properties of human intracranial blood vessels through biaxial tensile test and fitting them to a hyperelastic model

Shafigh

Fatouraee²,

Seddighi³

2013

10.5267/j.esm

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Understanding mechanical properties of healthy and unhealthy cerebral vessels is a key element in the development of their science and the relevant clinical diagnosis, prevention and treatment. Thirteen healthy samples were obtained from 23 middle cerebral arteries. The changes of force and deformation until the vessel rupture were recorded using a biaxial device. Thereafter, the stress-strain curve was plotted and fitted with a hyperelastic five-parameter Mooney-Rivlin model and the model parameters (C1, C2, C3, C4, and C5) were determined according to the best fit. For statistical comparison, the samples were divided into three age and two gender groups and subjected to non-parametric statistical analyses. Comparison of obtained results for different age groups showed that there is a significant difference between the "old" group and the other two groups (middle-aged and young). There was no significant difference between male and female groups. Therefore, the results demonstrate the changes of blood vessel wall properties with aging. The results also depicted that the arterial wall is stiffer in the circumferential direction than the axial direction. Anisotropy of cerebral vessels was confirmed by all of the tests. Therefore, the significance of the biaxial tests is in the spot light in the derived data. Moreover, good fitting of data illuminated that the use of multiple-parameter constitutive models is useful for mathematical demonstration of cerebral vessel tissue behavior. In conclusion, good fitting of data illuminated that the use of multiple-parameter constitutive models is useful for mathematical demonstration of cerebral vessel tissue behavior.}}

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Mechanical Properties of Dilated Human Ascending Aorta

Cited by 181 publications

References 36 publications

Biomechanical properties of the thoracic aorta in Marfan patients

Biomechanical properties of the thoracic aorta in Marfan patients

Biomechanical Determinants of Abdominal Aortic Aneurysm Rupture

Determining the biomechanical properties of human intracranial blood vessels through biaxial tensile test and fitting them to a hyperelastic model

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