Mechanical properties, in vitro degradation behavior, hemocompatibility and cytotoxicity evaluation of Zn–1.2Mg alloy for biodegradable implants

Abstract

The microstructure, mechanical properties, in vitro degradation behavior, in vitro hemocompatibility and cytotoxicity were tested to investigate Zn–1.2Mg alloy as a new biodegradable material.

Facile synthesis of biocompatible MoSe2 nanoparticles for efficient targeted photothermal therapy of human lung cancer

“…6a, no signicant hemolysis phenomenon was detected for FA-PL-MoSe 2 -treated RBCs below 250 mg mL À1 , similar to that of the negative PBS-treated group, suggesting an excellent hemocompatibility of FA-PL-MoSe 2 . 38,39 Moreover, the cytotoxicity of the nanoparticles on SPC-A-1 cells was evaluated by the CCK-8 assay. As shown in Fig.…”

The Prospects of Zinc as a Structural Material for Biodegradable Implants—A Review Paper

“…It can be seen from Table 5 that even minor alloying can significantly improve mechanical properties; for example, adding 0.15% Mg to pure zinc improves its ultimate tensile strength from 18 MPa to 250 MPa, and the elongation fraction from 0.32% to 22% [9,44]. Moreover, hot rolling and hot extrusion contribute to the strength and ductility of zinc alloys [3,9,44,46]. For example: the yield strength (YS), ultimate tensile strength (UTS) and elongation of as-cast Zn-1Mg-1Ca are 80 MPa, 130 MPa, and 1%, respectively.…”

“…In other cases, a chronic inflammatory response against the implant may undermine the therapeutic function of the device. In such circumstances, a second operation may be necessary to extract the implant, resulting in additional injury and expense [1,3,6,7].…”

“…During this time, metals have become widely used as orthopedic implants, cardiovascular interventional devices, and tissue engineering scaffolds, due to their high strength and toughness compared with polymers and ceramic materials [3,4]. Traditional metallic biomaterials with high corrosion resistance, such as titanium alloys, stainless steels, cobalt-chromium alloys and tantalum are generally used as permanent implants in patients [3][4][5].…”

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

“…Combination of Mg as an alloying element with Zn-based alloys especially about 1% is newly introduced and investigated by several researchers [54,55]. Shen et al [150] produced Zn-1.2% Mg alloy and achieved the high ultimate strength of 362 MPa and elongation of 21%, which is the highest ductility obtained for biodegradable Zn alloys. The combination of Zn with other alloying elements is still a challenging topic for researchers.…”