Mechanical properties and in vitro degradation of PLGA suture manufactured via electrospinning

Haghighat, Fatemeh; Ravandi, Seyed Abdolkarim Hosseini

doi:10.1007/s12221-014-0071-9

Cited by 39 publications

(29 citation statements)

References 23 publications

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“…In this regard, through the variation of the percentage of these two polymers, the degradation rate of PLGA products is controllable. Therefore, PLGA is preferred compared to PGA and could be used in various biomedical applications such as sutures and cancer drug delivery systems [ 80 , 81 ]. When the implants are made from PLGA, the rate of bone healing and growing has demonstrated a great acceleration [ 82 ].…”

Section: Introductionmentioning

confidence: 99%

A comprehensive review of biodegradable synthetic polymer-ceramic composites and their manufacture for biomedical applications

Alizadeh-Osgouei

Wen

2019

Bioactive Materials

217

114

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The application of various materials in biomedical procedures has recently experienced rapid growth. One area that is currently receiving significant attention from the scientific community is the treatment of a number of different types of bone-related diseases and disorders by using biodegradable polymer-ceramic composites. Biomaterials, the most common materials used to repair or replace damaged parts of the human body, can be categorized into three major groups: metals, ceramics, and polymers. Composites can be manufactured by combining two or more materials to achieve enhanced biocompatibility and biomechanical properties for specific applications. Biomaterials must display suitable properties for their applications, about strength, durability, and biological influence. Metals and their alloys such as titanium, stainless steel, and cobalt-based alloys have been widely investigated for implant-device applications because of their excellent mechanical properties. However, these materials may also manifest biological issues such as toxicity, poor tissue adhesion and stress shielding effect due to their high elastic modulus. To mitigate these issues, hydroxyapatite (HA) coatings have been used on metals because their chemical composition is similar to that of bone and teeth. Recently, a wide range of synthetic polymers such as poly (l-lactic acid) and poly (l-lactide-co-glycolide) have been studied for different biomedical applications, owing to their promising biocompatibility and biodegradability. This article gives an overview of synthetic polymer-ceramic composites with a particular emphasis on calcium phosphate group and their potential applications in tissue engineering. It is hoped that synthetic polymer-ceramic composites such as PLLA/HA and PCL/HA will provide advantages such as eliminating the stress shielding effect and the consequent need for revision surgery.

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Section: Introductionmentioning

confidence: 99%

A comprehensive review of biodegradable synthetic polymer-ceramic composites and their manufacture for biomedical applications

Alizadeh-Osgouei

Wen

2019

Bioactive Materials

217

114

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“…Poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and their copolymer, poly(lactic-co-glycolic acid) (PLGA), have been approved by the FDA for clinical uses, such as bioabsorbable sutures1 and bone fixation devices2. The applications of biodegradable polymers also extend to the fields of drug delivery carriers34 and tissue scaffolding56.…”

mentioning

confidence: 99%

“…Biodegradable polymers are attracting considerable interest in the field of biomedical applications because of their high mechanical strength, biocompatibility, and biodegradability. Poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and their copolymer, poly(lactic-co-glycolic acid) (PLGA), have been approved by the FDA for clinical uses, such as bioabsorbable sutures 1 and bone fixation devices 2 . The applications of biodegradable polymers also extend to the fields of drug delivery carriers 3 4 and tissue scaffolding 5 6 .…”

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confidence: 99%

Biodegradability of poly(lactic-co-glycolic acid) after femtosecond laser irradiation

Shibata

Yada

Terakawa

2016

Sci Rep

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Biodegradation is a key property for biodegradable polymer-based tissue scaffolds because it can provide suitable space for cell growth as well as tailored sustainability depending on their role. Ultrashort pulsed lasers have been widely used for the precise processing of optically transparent materials, including biodegradable polymers. Here, we demonstrated the change in the biodegradation of a poly(lactic-co-glycolic acid) (PLGA) following irradiation with femtosecond laser pulses at different wavelengths. Microscopic observation as well as water absorption and mass change measurement revealed that the biodegradation of the PLGA varied significantly depending on the laser wavelength. There was a significant acceleration of the degradation rate upon 400 nm-laser irradiation, whereas 800 nm-laser irradiation did not induce a comparable degree of change. The X-ray photoelectron spectroscopy analysis indicated that laser pulses at the shorter wavelength dissociated the chemical bonds effectively, resulting in a higher degradation rate at an early stage of degradation.

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“…PLGA PLGA is formed by the ring-opening copolymerization of PLA and PGA, and its degradation rate can be regulated by changing the percentage of these two polymers [82]. PLGA is a widely used biodegradable polymer that has the advantages of safety, biocompatibility, non-cytotoxicity, ideal mechanical properties and controllable degradation [46].…”

Section: Synthetic Biodegradable Polymersmentioning

confidence: 99%

Biodegradable materials for bone defect repair

et al. 2020

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Compared with non-degradable materials, biodegradable biomaterials play an increasingly important role in the repairing of severe bone defects, and have attracted extensive attention from researchers. In the treatment of bone defects, scaffolds made of biodegradable materials can provide a crawling bridge for new bone tissue in the gap and a platform for cells and growth factors to play a physiological role, which will eventually be degraded and absorbed in the body and be replaced by the new bone tissue. Traditional biodegradable materials include polymers, ceramics and metals, which have been used in bone defect repairing for many years. Although these materials have more or fewer shortcomings, they are still the cornerstone of our development of a new generation of degradable materials. With the rapid development of modern science and technology, in the twenty-first century, more and more kinds of new biodegradable materials emerge in endlessly, such as new intelligent micro-nano materials and cell-based products. At the same time, there are many new fabrication technologies of improving biodegradable materials, such as modular fabrication, 3D and 4D printing, interface reinforcement and nanotechnology. This review will introduce various kinds of biodegradable materials commonly used in bone defect repairing, especially the newly emerging materials and their fabrication technology in recent years, and look forward to the future research direction, hoping to provide researchers in the field with some inspiration and reference.

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Mechanical properties and in vitro degradation of PLGA suture manufactured via electrospinning

Cited by 39 publications

References 23 publications

A comprehensive review of biodegradable synthetic polymer-ceramic composites and their manufacture for biomedical applications

A comprehensive review of biodegradable synthetic polymer-ceramic composites and their manufacture for biomedical applications

Biodegradability of poly(lactic-co-glycolic acid) after femtosecond laser irradiation

Biodegradable materials for bone defect repair

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