Mechanical properties and in vitro response of strontium-containing hydroxyapatite/polyetheretherketone composites

Wong, Ka-Lok; Wong, Cho Lee; Liu, W. C.; Pan, Haobo; Fong, M.K.; Lam, Wwm; Cheung, William K.; Tang, Wing Man; Chiu, K. Y.; Luk, K.D.K.; Lu, William W.

doi:10.1016/j.biomaterials.2009.04.016

Cited by 180 publications

(115 citation statements)

References 21 publications

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“…Roeder's group densified PEEK and HA-whisker dry powders at 125 MPa first, to avoid porosity, and then compression moulded at 250 MPa and 350℃-370℃ [8] . Wong et al [5] described an alternative technique in which PEEK and strontium-containing HA (Sr-HA) powders were densified at 35 MPa and then compression b moulded at 12-15 MPa and 350℃-375℃. The use of injection pressures of 11-14 MPa and temperature of 395℃was previously used in the injection moulding of PEEK/HA compounds [4] .…”

Section: Resultsmentioning

confidence: 99%

“…Ma et al [41] used compression moulding to make a simple functionally graded PEEK/HA composites. Roeder's group at University of Notre Dame, USA, reported successful use of compression moulding and particulate leaching to make porous bioactive PEEK/HA-whisker composite [5][6][7][8] . Bioactive particles and/or a fugitive particle are mixed with PEEK powders, and then the mixture is densified by pressure, and finally, compression moulded.…”

Section: Discussionmentioning

confidence: 99%

“…Whilst addition of bioactive materials to PEEK offers an efficient method to engineer implants with tailored biomechanical properties, it may result in reduced strength and toughness of the implant [1] . Different processing methods such as compounding and injection moulding [2][3][4] , compression moulding [5][6][7][8] , cold press sintering [9][10][11] and selective laser sintering (SLS) [12][13][14] have been used to produce bioactive PEEK/HA and β-TCP composites.…”

Section: Introductionmentioning

confidence: 99%

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A novel bioactive PEEK/HA composite with controlled 3D interconnected HA network

Vaezi¹,

Yang²

2015

ijb

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Polyetheretherketone (PEEK) is a high-performance thermoplastic biomaterial which is currently used in a variety of biomedical orthopaedic applications. It has comparable tensile and compressive strength to cortical bone with favourable biocompatibility. However, natural grade PEEK-OPTIMA has shown insufficient bioactivity and limited bone integration. Bioactive PEEK composites (e.g., PEEK/calcium phosphates or Bioglass) and porous PEEK have been used to improve bone-implant interface of PEEK-based devices, but the bioactive phase distribution or porosity control is poor. In this paper, a novel method is developed to fabricate a bioactive PEEK/hydroxyapatite (PEEK/HA) composite with a unique configuration in which the HA (bioactive phase) distribution is computer-controlled within a PEEK matrix. This novel process results in complete interconnectivity of the HA network within a composite material, representing a superior advantage over alternative forms of product. The technique combines extrusion freeforming, a type of additive manufacturing (AM), and compression moulding. Compression moulding parameters, including pressure, temperature, dwelling time, and loading method together with HA microstructure were optimized by experimentation for successful biocomposite production. PEEK/HA composites with a range of HA were produced using static pressure loading to minimise air entrapment within PEEK matrix. In addition, the technique can also be employed to produce porous PEEK structures with controlled pore size and distribution.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A novel bioactive PEEK/HA composite with controlled 3D interconnected HA network

Vaezi¹,

Yang²

2015

ijb

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show abstract

“…Hence, surface engineering of biomaterials is aimed at modifying the material and biological responses through the surface changes while maintaining the bulk mechanical properties of the implant [5]. There have been several ways to improve the bioactivity of polymers for the use of bone repair, such as compounding with bioactive inorganic particles [2,3,6], grafting with bioactive groups [7] and forming bioactive coatings [8,9]. Compared with the first two methods, coating is relatively easy and low cost.…”

Section: Introductionmentioning

confidence: 99%

“…Because of its similarity to the inorganic component of human hard tissues, synthetic hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , HA) could be the first candidate for bioactive coating of orthopaedic implants. Various techniques have been investigated for coating HA onto metallic or non-metallic implants, including plasma spraying [10][11][12][13], sol -gel processing [14], electrophoretic deposition [15] and biomimetic coating [16,17].…”

Section: Introductionmentioning

confidence: 99%

Bioactive composite gradient coatings of nano-hydroxyapatite/polyamide66 fabricated on polyamide66 substrates

Huang

Zuo

et al. 2012

J. R. Soc. Interface.

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Tightly bonding of bioactive coating is the first crucial need for orthopaedic implants. This study describes a novel and convenient technique to prepare bioactive coating with high adhesion on orthopaedic substitutes made of polymeric matrix. Here, a chemical corrosion method has been adopted to fabricate a coating on the surface of injection-moulded polyamide66 (PA66) substrates by corrosive nano-hydroxyapatite/polyamide66 (n-HA/PA66) composite slurry. Scanning electron microscopy observation shows that a porous chemical corrosion region presents between the coating and dense PA66 substrate. Energy-dispersive X-ray spectroscopy analysis indicates that the chemical corrosion region is mainly composed of PA66 matrix, and the coating layer is an n-HA-rich layer. Both the pore size and n-HA composition increase gradually from the polymeric substrate towards the coating surface. Mechanical testing shows the bonding strength can reach 13.7 + 0.2 MPa, which is much higher than that fabricated on polymeric matrix by other coating methods. The gradual transition in coating structure and composition benefits for the interface bonding and for the surface bone-bonding bioactivity. Subsequent cell experiments corroborate n-HA-rich coating and a porous structure is benefitting for cell attachment and proliferation. The convenient coating method could be popularized and applied on similar polymer implants to produce a tightly and porous bioactive coating for bone tissue regeneration.

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Bioactive Polymers and Nanobiomaterials Composites for Bone Tissue Engineering

Khan¹,

Ahmad²

2013

Biomimetics

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Mechanical properties and in vitro response of strontium-containing hydroxyapatite/polyetheretherketone composites

Cited by 180 publications

References 21 publications

A novel bioactive PEEK/HA composite with controlled 3D interconnected HA network

A novel bioactive PEEK/HA composite with controlled 3D interconnected HA network

Bioactive composite gradient coatings of nano-hydroxyapatite/polyamide66 fabricated on polyamide66 substrates

Bioactive Polymers and Nanobiomaterials Composites for Bone Tissue Engineering

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