Mechanical properties and characteristics of microtubules: A review

Liew, K.M.; Xiang, Ping; Zhang, Luwen

doi:10.1016/j.compstruct.2014.12.020

Cited by 32 publications

(16 citation statements)

References 162 publications

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“…This fundamental difference grants individual intermediate filaments the ability to withstand strains much larger than 100% and a nonlinear stress–strain relationship—actin filaments and microtubules exhibit linear stress–strain relationships and much lower yield strains (see Figure (b)). Readers are directed to several excellent reviews for further detailed measurements and models of the mechanical behavior of the three filament types and their networks. Here, we summarize some key measurements of how the different components of the cytoskeleton contribute to the emergent mechanical behavior of the composite cytoskeleton and review models that account for these distinct contributions to cytoskeleton and cell mechanics.…”

Section: Measurements and Models Of The Contribution Of Cytoskeletal mentioning

confidence: 99%

“…While there have been many studies that investigated the stiffness of intermediate filaments and microtubules, more experimental and computational studies are needed to understand the mechanisms that govern microtubule and intermediate filament network dynamics (as mentioned in Mechanics of Microtubules and Intermediate Filament Networks and Mathematical Models of Microtubules and Intermediate Filament Networks ). Their contributions to the emergent behavior of the cell cytoskeleton have also only gained increased traction recently.…”

Section: Measurements and Models Of The Contribution Of Cytoskeletal mentioning

confidence: 99%

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Computational modeling of single‐cell mechanics and cytoskeletal mechanobiology

Rajagopal

Holmes

Lee

2017

WIREs Mechanisms of Disease

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Cellular cytoskeletal mechanics plays a major role in many aspects of human health from organ development to wound healing, tissue homeostasis and cancer metastasis. We summarize the state‐of‐the‐art techniques for mathematically modeling cellular stiffness and mechanics and the cytoskeletal components and factors that regulate them. We highlight key experiments that have assisted model parameterization and compare the advantages of different models that have been used to recapitulate these experiments. An overview of feed‐forward mechanisms from signaling to cytoskeleton remodeling is provided, followed by a discussion of the rapidly growing niche of encapsulating feedback mechanisms from cytoskeletal and cell mechanics to signaling. We discuss broad areas of advancement that could accelerate research and understanding of cellular mechanobiology. A precise understanding of the molecular mechanisms that affect cell and tissue mechanics and function will underpin innovations in medical device technologies of the future. WIREs Syst Biol Med 2018, 10:e1407. doi: 10.1002/wsbm.1407This article is categorized under: Models of Systems Properties and Processes > Mechanistic ModelsPhysiology > Mammalian Physiology in Health and DiseaseModels of Systems Properties and Processes > Cellular Models

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Section: Measurements and Models Of The Contribution Of Cytoskeletal mentioning

confidence: 99%

Section: Measurements and Models Of The Contribution Of Cytoskeletal mentioning

confidence: 99%

Computational modeling of single‐cell mechanics and cytoskeletal mechanobiology

Rajagopal

Holmes

Lee

2017

WIREs Mechanisms of Disease

View full text Add to dashboard Cite

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“…The nucleation of microtubules usually starts at the microtubule organization center (MTOC), which is comprised of the γ‐tubulin ring complex . Owing to the thermodynamic instability of tubulin polymerization, microtubules are in constant transition between rapid growth and disassembly . Their growth occurs as the αβ tubulin interacts with GTP.…”

Section: Structure and Functional Phenotypesmentioning

confidence: 99%

“…The alternation between growth and catastrophe, termed dynamic instability, occurs as the cells modulate the stability of MTs through various factors . The dynamic stability is important for force generation by MTs; the steric energy stored in the unfavorable conformation of a straight protofilament is released during catastrophe to provide energy for other phenomena, such as mitotic spindle formation …”

Section: Structure and Functional Phenotypesmentioning

confidence: 99%

Unraveling the Mechanobiology of the Immune System

Kim

Shin

et al. 2019

Adv Healthcare Materials

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Cells respond and actively adapt to environmental cues in the form of mechanical stimuli. This extends to immune cells and their critical role in the maintenance of tissue homeostasis. Multiple recent studies have begun illuminating underlying mechanisms of mechanosensation in modulating immune cell phenotypes. Since the extracellular microenvironment is critical to modify cellular physiology that ultimately determines the functionality of the cell, understanding the interactions between immune cells and their microenvironment is necessary. This review focuses on mechanoregulation of immune responses mediated by macrophages, dendritic cells, and T cells, in the context of modern mechanobiology.

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“…Microtubules play an important role in plant cell morphology and development (Liew et al 2015). For example, microtubule depolymerization by a specific antagonist causes the loss of directionality of root hair growth (Bibikova et al 1999).…”

Section: Candidate Genes and Possible Mechanism Causing Abnormal Growmentioning

confidence: 99%

Genetic fine mapping and candidate gene analysis of the Gossypium hirsutum Ligon lintless-1 (Li1) mutant on chromosome 22(D)

et al. 2015

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Ligon lintless-1 (Li1) is a Gossypium hirsutum mutant that is controlled by a dominant gene that arrests the development of cotton fiber after anthesis. Two F2 mapping populations were developed from mutant (Li1 × H7124) F1 plants in 2012 and 2013; each was composed of 142 and 1024 plants, respectively. Using these populations, Li1 was mapped to a 0.3-cM region in which nine single-strand conformation polymorphism markers co-segregated with the Li1 locus. In the published G. raimondii genome, these markers were mapped to a region of about 1.2 Mb (the Li1 region) and were separated by markers that flanked the Li1 locus in the genetic map, dividing the Li1 region into three segments. Thirty-six genes were annotated by the gene prediction software FGENESH (Softberry) in the Li1 region. Twelve genes were candidates of Li1, while the remaining 24 genes were identified as transposable elements, DNA/RNA polymerase superfamily or unknown function genes. Among the 12 candidate genes, those encoding ribosomal protein s10, actin protein, ATP synthase, and beta-tubulin 5 were the most-promising candidates of the Li1 mutant because the function of these genes is closely related to fiber development. High-throughput RNA sequencing and quantitative PCR revealed that these candidate genes had obvious differential gene expression between mutant and wild-type plants at the fiber elongation stage, strengthening the inference that they could be the most likely candidate gene of the Li1 mutant phenotype.

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Mechanical properties and characteristics of microtubules: A review

Cited by 32 publications

References 162 publications

Computational modeling of single‐cell mechanics and cytoskeletal mechanobiology

Computational modeling of single‐cell mechanics and cytoskeletal mechanobiology

Unraveling the Mechanobiology of the Immune System

Genetic fine mapping and candidate gene analysis of the Gossypium hirsutum Ligon lintless-1 (Li1) mutant on chromosome 22(D)

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