Mechanical properties and biomineralization of multifunctional nanodiamond-PLLA composites for bone tissue engineering

Zhang, Qingwei; Mochalin, Vadym; Neitzel, Ioannis; Hazeli, Kavan; Niu, Junjie; Kontsos, Antonios; Zhou, Jack G.; Lelkes, Peter I.; Gogotsi, Yury

doi:10.1016/j.biomaterials.2012.03.063

Cited by 214 publications

(153 citation statements)

References 60 publications

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“…However, few scaffolds can fit all of these qualifications. Among the variety of biomaterials used in the biomedical field, poly (L-lactic acid) (PLLA) is one of the polymers most widely employed for the regeneration of different tissues or organs, like bone [4,5], cartilage [6] and skin [7], because of its relatively good mechanical and manufacturing properties. However, the biomedical applications of PLLA are hampered to a certain extent by its high hydro -phobicity and lack of physiological activity [8,9].…”

Section: Introductionmentioning

confidence: 99%

LBL coating of type I collagen and hyaluronic acid on aminolyzed PLLA to enhance the cell-material interaction

Zhao¹,

Zhou²,

Li³

et al. 2014

Express Polym. Lett.

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Abstract. The aim of the present work is to assemble extracellular matrix components onto poly (L-lactic acid) (PLLA) films using layer-by-layer (LBL) depositing method to enhance the cell-material interaction. To introduce charges onto the hydrophobic and neutral PLLA surface so that the electronic assembly can be processed, poly (ethylene imine) (PEI) was covalently bonded to modify the PLLA films. Positively charged collagen I (Col I) was then deposited onto the aminolyzed PLLA film surface in a LBL assembly manner using hyaluronic acid (HA) as a negatively charged polyelectrolyte. The PEI modification efficiency was monitored via X-ray photoelectron spectroscopy (XPS) measurements. The results of Surface Plasmon Resonance (SPR) and Water contact angle (WCA) monitoring the LBL assemble process presented that the HA/Col I deposited alternately onto the PLLA surface. The surface topography of the films was observed by Atomic force microscope (AFM). In vitro osteoblast culture found that the presence of Col I layer greatly improved the cytocompatibility of the PLLA films in terms of cell viability, cell proliferation and Alkaline Phosphatase (ALP) expression. Furthermore, osteoblast extensions were found to be directed by contact guidance of the aligned Col I fibrils. Thus, these very flexible systems may allow broad applications for improve the bioactivity of polymeric materials, which might be a potential application for bone tissue engineering.

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Section: Introductionmentioning

confidence: 99%

LBL coating of type I collagen and hyaluronic acid on aminolyzed PLLA to enhance the cell-material interaction

Zhao¹,

Zhou²,

Li³

et al. 2014

Express Polym. Lett.

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“…Polymeric composite biomaterials, as implant materials for replacing hard tissues of human body, have attracted increasing attention due to their designed structure and physical properties overcoming the disadvantages of metallic and ceramic materials currently adopted in orthopedic application [1][2][3]. The polymeric composite materials prepared by the addition of bioactive hydroxyapatite (HA) fillers in the polyethylene (PE) matrix, as bone analogue, were first introduced by Bonfield [4].…”

Section: Introductionmentioning

confidence: 99%

Mechanical performance and in vivo bioactivity of functionally graded PEEK–HA biocomposite materials

Lin

Luo

et al. 2014

J Sol-Gel Sci Technol

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A functionally graded material (FGM) of polyetheretherketone (PEEK)-hydroxyapatite (HA) with a symmetrical three-layer structure containing 8.7, 2.6 and 8.7 vol% HA, respectively, is successfully fabricated by hot pressing and evaluated by scanning electron microscopy and tensile testing. A good bonding between the HA particles and the PEEK matrix is achieved by virtue of an in situ method in fabricating each PEEK-HA composite layer. There are no apparent microcracks and microscopic interfaces within each layer of the FGM. The symmetrical PEEK-HA FGM does not fall apart or delaminate during loading with a tensile strength of 86.2 MPa, and its fracture energy is 56.5 kJ/m 2 . Furthermore, in vivo bioactivity of the FGM sample is also evaluated, showing that it has sound biocompability and bioactivity. Accordingly, the FGM in the future may be a promising biomaterial to be used as replacement implant of human bone through a proper design to balance mechanical properties and bioactivity.

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“…Moreover, the minimal interaction between the fibers and the polymeric matrix noticeably reduces the nanocomposites strength. 95,128,129 Some of treatment processes involve usage of saline coupling agent 111,130 or ultrasonication or mixer 120 or plasma functionalization 131,132 to achieve uniform distribution of the particles while forming nanobiocomposites. Zhang et al 133 reported that the functionalized carbon nanotubes have better biocompatibility and water miscibility.…”

Section: Modification Of Polymeric Nanobiocompositesmentioning

confidence: 99%

Polymeric nanobiocomposites for biomedical applications

Mozumder

Mairpady

Mourad

2016

J. Biomed. Mater. Res.

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Polymeric nanobiocomposites have recently become one of the most essential sought after materials for biomedical applications ranging from implants to the creation of gels. Their unique mechanical and biological properties provide them the ability to pass through the highly guarded defense mechanism without undergoing noticeable degradation and initiation of immune responses, which in turn makes them advantageous over the other alternatives. Aligned with the advances in tissue engineering, it is also possible to design three-dimensional extracellular matrix using these polymeric nanobiocomposites that could closely mimic the human tissues. In fact, unique polymer chemistry coupled with nanoparticles could create unique microenvironment that promotes cell growth and differentiation. In addition, the nanobiocomposites can also be devised to carry drugs efficiently to the target site without exhibiting any cytotoxicity as well as to eradicate surgical infections. In this article, an effort has been made to thoroughly review a number of different types/classes of polymeric nanocomposites currently used in biomedical fields. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1241-1259, 2017.

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Mechanical properties and biomineralization of multifunctional nanodiamond-PLLA composites for bone tissue engineering

Cited by 214 publications

References 60 publications

LBL coating of type I collagen and hyaluronic acid on aminolyzed PLLA to enhance the cell-material interaction

LBL coating of type I collagen and hyaluronic acid on aminolyzed PLLA to enhance the cell-material interaction

Mechanical performance and in vivo bioactivity of functionally graded PEEK–HA biocomposite materials

Polymeric nanobiocomposites for biomedical applications

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