Mechanical loading of rigid intramuscular implants

Loeb, Gerald E.; Peck, R.A.; Singh, Jasspreet; Kim, Young Ho; Deshpande, Sudeep; Baker, Lucinda L.; Bryant, J. T.

doi:10.1007/s10544-006-9031-5

Cited by 7 publications

(5 citation statements)

References 13 publications

(17 reference statements)

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“…Similarly, the first generation BION microstimulator used a glass housing to enhance RF transparency, but found that the housing was prone to fracture after repeated bending stress due to muscle contraction (Fig. 2b) (Loeb, et al, 2007). Careful mechanical design was able to improve the strength of the BION glass housing; subsequent versions of the implant utilized a ceramic housing with a 7x improvement in bending strength (Kane, et al, 2011).…”

Section: Classical Ceramic Packaging Methodsmentioning

confidence: 99%

“…In cochlear implants, all-alumina housing was explored by Cochlear Ltd, MED-EL, and Neurolec, but due to the large amount of exposed area, the housings were vulnerable to failure due to mechanical impact [55]. Similarly, the first generation BION microstimulator used a glass housing to enhance RF transparency, but found that the housing was prone to fracture after repeated bending stress due to muscle contraction (figure 2) [56]. Careful mechanical design was able to improve the strength of the BION glass housing; subsequent versions of the implant utilized a ceramic housing with a 7× improvement in bending strength [57].…”

Section: Classical Ceramic Packaging Methodsmentioning

confidence: 99%

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Ceramic packaging in neural implants

Shen

Maharbiz

2021

J. Neural Eng.

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The lifetime of neural implants is strongly dependent on packaging due to the aqueous and biochemically aggressive nature of the body. Over the last decade, there has been a drive towards neuromodulatory implants which are wireless and approaching millimeter-scales with increasing electrode count. A so-far unrealized goal for these new types of devices is an in-vivo lifetime comparable to a sizable fraction of a healthy patient’s lifetime (>10–20 years). Existing, approved medical implants commonly encapsulate components in metal enclosures (e.g. titanium) with brazed ceramic inserts for electrode feedthrough. It is unclear how amenable the traditional approach is to the simultaneous goals of miniaturization, increased channel count, and wireless communication. Ceramic materials have also played a significant role in traditional medical implants due to their dielectric properties, corrosion resistance, biocompatibility, and high strength, but are not as commonly used for housing materials due to their brittleness and the difficulty they present in creating complex housing geometries. However, thin-film technology has opened new opportunities for ceramics processing. Thin films derived largely from the semiconductor industry can be deposited and patterned in new ways, have conductivities which can be altered during manufacturing to provide conductors as well as insulators, and can be used to fabricate flexible substrates. In this review, we give an overview of packaging for neural implants, with an emphasis on how ceramic materials have been utilized in medical device packaging, as well as how ceramic thin-film micromachining and processing may be further developed to create truly reliable, miniaturized, neural implants.

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Section: Classical Ceramic Packaging Methodsmentioning

confidence: 99%

Section: Classical Ceramic Packaging Methodsmentioning

confidence: 99%

Ceramic packaging in neural implants

Shen

Maharbiz

2021

J. Neural Eng.

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show abstract

“…10). No injury was suffered by the patients, but this discovery triggered a voluntary suspension of clinical trials and effort shifted to root-cause analysis [55]. The failures were attributed to stress risers appearing from the application of repetitive shear forces between the electrodes and the glass body.…”

Section: Clinical Testsmentioning

confidence: 99%

“…Broken BION capsules move with wrist flexure, but patients reported no symptoms except loss of function[55]. Reproduced with permission from Springer Science+Business Media: Biomedical Microdevices, Mechanical Loading of Rigid Intramuscular Implants, 2007;9: p902, Loeb,Fig 1.…”

mentioning

confidence: 99%

BION microstimulators: A case study in the engineering of an electronic implantable medical device

Kane

Breen

Quondamatteo

et al. 2011

Medical Engineering & Physics

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“…a) Cracked alumina casing in a cochlear implant due to mechanical impact of the head(Stöver & Lenarz, 2009). b) Broken intramuscular microstimulators encased in glass housing due to bending stresses from muscle contractions(Loeb, et al, 2007).…”

mentioning

confidence: 99%

Ceramic Packaging in Neural Implants

Shen

Maharbiz

2020

Preprint

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AbstractThe lifetime of neural implants is strongly dependent on packaging due to the aqueous and biochemically aggressive nature of the body. Over the last decade, there has been a drive towards neuromodulatory implants which are wireless and approaching millimeter-scales with increasing electrode count. A so-far unrealized goal for these new types of devices is an in-vivo lifetime comparable to a sizable fraction of a healthy patient’s lifetime (>10-20 years). Existing, approved medical implants commonly encapsulate components in metal enclosures (e.g. titanium) with brazed ceramic inserts for electrode feedthrough. It is unclear how amenable the traditional approach is to the simultaneous goals of miniaturization, increased channel count, and wireless communication. Ceramic materials have also played a significant role in traditional medical implants due to their dielectric properties, corrosion resistance, biocompatibility, and high strength, but are not as commonly used for housing materials due to their brittleness and the difficulty they present in creating complex housing geometries. However, thin film technology has opened new opportunities for ceramics processing. Thin films derived largely from the semiconductor industry can be deposited and patterned in new ways, have conductivities which can be altered during manufacturing to provide conductors as well as insulators, and can be used to fabricate flexible substrates. In this review, we give an overview of packaging for neural implants, with an emphasis on how ceramic materials have been utilized in medical device packaging, as well as how ceramic thin film micromachining and processing may be further developed to create truly reliable, miniaturized, neural implants

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Mechanical loading of rigid intramuscular implants

Cited by 7 publications

References 13 publications

Ceramic packaging in neural implants

Ceramic packaging in neural implants

BION microstimulators: A case study in the engineering of an electronic implantable medical device

Ceramic Packaging in Neural Implants

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