Mechanical loading leads to osteoarthritis-like changes in the hypofunctional temporomandibular joint in rats

Effects of bisphosphonates on mandibular condyle of ovariectomized osteoporotic rats using micro‐ct and histomorphometric analysis

“…The condylar cartilage could be subdivided into four layers that can be easily distinguished by H&E staining in the Sham‐operated group (Fig. A,B) . In the OVX group, the cartilage thickness of the anterior and superior region was irregular with a decrease when compared to sham group (165.07 ± 31.26 μm vs. 213.77 ± 34.52 μm, respectively, P < 0.05), whereas there was a significantly increased thickness of cartilage, especially of hypertrophic chondrocyte layers (low mineralization area) in the RIS group compared to the OVX group (Fig.…”

“…4A,B). (19,20) In the OVX group, the cartilage thickness of the anterior and superior region was irregular with a decrease when compared to sham group (165.07 AE 31.26 lm vs. 213.77 AE 34.52 lm, respectively, P < 0.05), whereas there was a significantly increased thickness of cartilage, especially of hypertrophic chondrocyte layers (low mineralization area) in the RIS group compared to the OVX group (Fig. 4A,B) (270.89 AE 43.77 lm vs. 165.07 AE 31.26 lm, respectively, P < 0.05).…”

Expression of endoplasmic reticulum stress protein in rabbit condyle cartilage following anterior disk displacement

“…Anterior disk displacement (ADD) is a most common subtype of temporomandibular disorders (TMD), which is characterized by gradual degeneration of articular cartilage, synovial inflammation, and pain, resulting in significant disability . Sustained excessive joint loading associated with TMD is considered to be a risk factor for osteoarthritis (OA) development by promoting chondrocytes apoptosis . Previous researches have demonstrated the correlation between TMD and apoptosis .…”

“…1,2 Sustained excessive joint loading associated with TMD is considered to be a risk factor for osteoarthritis (OA) development by promoting chondrocytes apoptosis. 3 Previous researches have demonstrated the correlation between TMD and apoptosis. [4][5][6][7] However, the signaling pathways that trigger apoptosis of chondrocytes during the development of TMD are still unknown.…”

Letter to the Editor: Impact of Overloading on Temporomandibular Joint Osteoarthritis

“…Additionally, a mechanical loading on the TMJ and the use of a liquid diet during the growing period of male Wistar rats induced TMJOAlike changes due to the excessive loading (Ikeda et al 2014). TMJ overloading mechanisms are thought to be similar to those in other synovial joints, where hypertrophic chondrocytes respond with increased metabolic activity and activation of pathologic processes, leading to irreversible cartilage degradation and osteoarthritis (Kuroda et al 2009).…”