Mechanical loading intensities affect the release of extracellular vesicles from mouse bone marrow‐derived hematopoietic progenitor cells and change their osteoclast‐modulating effect
C. Bratengeier,
L. Johansson,
A. Liszka
et al.
Abstract:Low‐intensity loading maintains or increases bone mass, whereas lack of mechanical loading and high‐intensity loading decreases bone mass, possibly via the release of extracellular vesicles by mechanosensitive bone cells. How different loading intensities alter the biological effect of these vesicles is not fully understood. Dynamic fluid shear stress at low intensity (0.7 ± 0.3 Pa, 5 Hz) or high intensity (2.9 ± 0.2 Pa, 1 Hz) was used on mouse hematopoietic progenitor cells for 2 min in the presence or absenc… Show more
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