“…Osteocytes are good mechanosensors (i.e., they detect changes of mechanical stimuli) in bone tissue which serve to sense and respond to alterations produced when a bone is mechanically loaded. Such alterations may be physical deformation of the bone matrix, fluid flow shear stress generated by variations in canalicular fluid flow and electrical streaming potentials (Bonewald and Mundy, 1990;Mundy, 1993;Manolagas, 2000;Miyauchi et al, 2000;Bonewald and Johnson, 2008;Datta et al, 2008;Parra-Torres et al, 2013;Takemura et al, 2019). Mechanical strain signal is converted into a cellular response (i.e., biochemical signals) with the participation of membrane proteins (such as CD44, connexins, integrins, and ion channels) and downstream mediators of intracellular signaling (such as guanine regulatory proteins, mitogen activated protein kinase, cyclic adenosine monophosphate, inositol triphosphate, and intracellular calcium) (Rawlinson et al, 1996;Burger and Klein-Nulend, 1999;Mikuni-Takagaki, 1999;Miyauchi et al, 2000;Gu et al, 2001;Alford et al, 2003;Kapur et al, 2003;Plotkin et al, 2005;Rubin et al, 2006;Miyauchi et al, 2006).…”