“…Emerging evidence suggests that within a tumor microenvironment EVs are crucial factors in the communication between cancer and normal cells, influencing cancer onset, progression and metastatization ( Tai et al, 2018 ; Dai et al, 2020 ). In turn, cancer cells can modulate EV production by altering the microenvironment in terms of mechanics ( Eichholz et al, 2020 ; Nicastro et al, 2020 ) and acidity ( Parolini et al, 2009 ; Logozzi et al, 2018 ). In the bone microenvironment, EVs are known to participate in tissue remodeling process by regulating the fine equilibrium between bone deposition and bone resorption, at both physiological and pathological levels, as well as in the tissue engineering-based bone regeneration ( Eichholz et al, 2020 ; Yan et al, 2020 ).…”