Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons
Guoqiang Wang,
Ryan Guasp,
Sangeena Salam
et al.
Abstract:Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate extrusion of large vesicles, such as exophers produced by proteostressedC. eleganstouch neurons, are poorly understood. Here we document that mechanical force can significantly potentiate exopher extrusion from proteostressed neurons. Exopher production from theC. elegansALMR neuron peaks at adult day 2 or… Show more
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