Mechanical fatigue of whole rabbit-tibiae under combined compression-torsional loading is better explained by strained volume than peak strain magnitude

Haider, Ifaz T.; Lee, Mattea; Page, Rebecca; Smith, Donovan; Edwards, W. Brent

doi:10.1016/j.jbiomech.2021.110434

Cited by 12 publications

(10 citation statements)

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“…found no differences in strained volume of the tibia after 30 min of downhill running (Khassetarash et al., 2023), but it is not clear if this finding is specific to the downhill nature of the running. Strained volume may be a better predictor of bone failure than peak magnitude (Haider et al., 2021), and investigation of strained volume using participant specific imaging and density data would aid understanding of the present findings.…”

Section: Discussionmentioning

confidence: 90%

Tibial loading and damage accumulation in recreational and competitive male runners during a demanding 10 km run

Rice,

Mai,

Sanno

et al. 2024

European Journal of Sport Science

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Tibial stress injuries are problematic among runners. The loading magnitude is the most important mechanical contributor to bone damage accumulation, but loading quantity is also important, and faster runners require fewer loading cycles to complete a given distance than slower runners. This study estimated tibial loading and damage accumulation throughout a demanding 10‐km run in recreational (RR) and competitive runners (CR). Male runners reporting a 10‐km season‐best run slower than 47:30 min (RR) or faster than 37:30 min (CR) completed a 10‐km treadmill running protocol at 105% of their season's best time. Tibial loading was estimated from bending moments at the distal 1/3rd of the tibia by ensuring static equilibrium at each 1% of stance. Peak loading was obtained, and cumulative damage per kilometer was estimated using a tissue‐dependent weighting factor. Peak tibial loading and damage accumulation per kilometer significantly decreased throughout the run, by 5% and 4%, respectively. Peak loading was significantly higher (31%) in CR than RR, and there was an indication (p = 0.058 and large effect size) of a greater rate of damage accumulation in CR than RR. Tibial loading per step and the rate of accumulation per kilometer decreased throughout a demanding 10‐km run suggesting that changes in running mechanics as a result of prolonged running may not be a primary mechanism for stress injury development. Competitive runners experience greater peak tibial loading and possibly greater cumulative tibial damage when they complete 10 km faster than recreational runners.

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Section: Discussionmentioning

confidence: 90%

Tibial loading and damage accumulation in recreational and competitive male runners during a demanding 10 km run

Rice,

Mai,

Sanno

et al. 2024

European Journal of Sport Science

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“…Moreover, most studies that investigated patellofemoral, 9,10 tibial, [12][13][14][15] and Achilles tendon load did not consider the non-linear relationship between load and damage. 4 However, ex vivo studies show that the fatigue life of bone and tendinous tissue follows an inverse powerlaw relationship, [20][21][22][23] whereby higher loading magnitudes shorten the time to tissue failure substantially more than a higher number of loading cycles. For example, Wren and colleagues 21 found the human Achilles tendon to fail on average after 1400 cycles when stretched to 6% strain while stretching to half the strain magnitude (i.e., 3%) increased fatigue life by 6600% (i.e., failure occurred after 93 000 cycles).…”

Section: Introductionmentioning

confidence: 99%

“…24,30 Ex vivo studies show that stress and in particular the resulting strain show strong associations with cortical bone fatigue-life. 23 Information regarding the peak compressive stress and resulting damage at this location could therefore be useful to inform on tibial injury risk. Finally, Achilles tendinopathy is characterized by pain occurring 2-6 cm proximal to the tendon insertion 31 and is believed to primarily result from repetitive longitudinal tendon strain.…”

Section: Introductionmentioning

confidence: 99%

“…Tibial medial stress fractures often occur along the distal third of the posteromedial border of the tibia, 6 which is also the location with peak compressive stresses 24,30 . Ex vivo studies show that stress and in particular the resulting strain show strong associations with cortical bone fatigue‐life 23 . Information regarding the peak compressive stress and resulting damage at this location could therefore be useful to inform on tibial injury risk.…”

Section: Introductionmentioning

confidence: 99%

“…This nonlinear relationship between load and damage can be modeled by applying a weighting factor ( b ) to a given load (e.g., stress or strain value), with this weighting factor reflecting the slope of the power function between fatigue life and the tissue‐specific stress or strain 4,16,24 . For example, weighting factors of 7 and 9.3 have been derived for bone and tendon tissue, respectively 4,16,21,23 . Research conducted by Firminger and colleagues 16 underscores the importance of this nonlinear relationship when examining the impact of speed on the risk of Achilles tendon injuries, as the cumulative impulse decreased with higher speeds, while the cumulative weighted impulse (i.e., a proxy of damage; often referred to as cumulative damage in the literature) and the probability of injury increased.…”

Section: Introductionmentioning

confidence: 99%

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Per‐step and cumulative load at three common running injury locations: The effect of speed, surface gradient, and cadence

Van Hooren,

van Rengs,

Meijer

2024

Scandinavian Med Sci Sports

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Understanding how loading and damage on common running injury locations changes across speeds, surface gradients, and step frequencies may inform training programs and help guide progression/rehabilitation after injuries. However, research investigating tissue loading and damage in running is limited and fragmented across different studies, thereby impairing comparison between conditions and injury locations. This study examined per‐step peak load and impulse, cumulative impulse, and cumulative weighted impulse (hereafter referred to as cumulative damage) on three common injury locations (patellofemoral joint, tibia, and Achilles tendon) across different speeds, surface gradients, and cadences. We also explored how cumulative damage in the different tissues changed across conditions relative to each other. Nineteen runners ran at five speeds (2.78, 3.0, 3.33, 4.0, 5.0 m s−1), and four gradients (−6, −3, +3, +6°), and three cadences (preferred, ±10 steps min−1) each at one speed. Patellofemoral, tibial, and Achilles tendon loading and damage were estimated from kinematic and kinetic data and compared between conditions using a linear mixed model. Increases in running speed increased patellofemoral cumulative damage, with nonsignificant increases for the tibia and Achilles tendon. Increases in cadence reduced damage to all tissues. Uphill running increased tibial and Achilles tendon, but decreased patellofemoral damage, while downhill running showed the reverse pattern. Per‐step and cumulative loading, and cumulative loading and cumulative damage indices diverged across conditions. Moreover, changes in running speed, surface gradient, and step frequency lead to disproportional changes in relative cumulative damage on different structures. Methodological and practical implications for researchers and practitioners are discussed.

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Tibial-fibular geometry and density variations associated with elevated bone strain and sex disparities in young active adults

Bruce

Baggaley

Khassetarash

et al. 2022

Bone

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Mechanical fatigue of whole rabbit-tibiae under combined compression-torsional loading is better explained by strained volume than peak strain magnitude

Cited by 12 publications

References 50 publications

Tibial loading and damage accumulation in recreational and competitive male runners during a demanding 10 km run

Tibial loading and damage accumulation in recreational and competitive male runners during a demanding 10 km run

Per‐step and cumulative load at three common running injury locations: The effect of speed, surface gradient, and cadence

Tibial-fibular geometry and density variations associated with elevated bone strain and sex disparities in young active adults

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