Mechanical determinants of osteoarthrosis

Radin, Eric L.; Burr, David B.; Caterson, Bruce; Fyhrie, David P.; Brown, Thomas; Boyd, Robert D.

doi:10.1016/0049-0172(91)90036-y

Cited by 291 publications

(158 citation statements)

References 44 publications

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“…A cutoff of 2 mm was chosen because Ͻ2 mm medial JSW is considered to indicate advanced disease (28). The OA sample and the normative reference group were comparable for age, but 30 Fransen et al the OA sample had a higher body weight in each stratified group (Table 1). A large proportion of this sample of referred patients with knee OA reported symptom duration of 5 years or longer and advanced radiographic disease.…”

Section: Resultsmentioning

confidence: 83%

“…The loss of force with aging has been attributed to both a loss of functioning motor neurons as well as a reduced number of fast-twitch muscle fibers (29). Both animal and human studies have demonstrated that loading rate, rather than load magnitude, is the critical factor for cartilage damage in OA (30). Fast-twitch muscle fibers function to rapidly develop high tension for short periods of time, and, arguably, isometric testing is a poor indicator of the capacity of a muscle to reduce potentially destructive high loading rates.…”

Section: Discussionmentioning

confidence: 99%

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Isometric muscle force measurement for clinicians treating patients with osteoarthritis of the knee

Fransen¹,

Crosbie²,

Edmonds³

2003

Arthritis & Rheumatism

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Objective. To evaluate the discriminant validity and, for clinicians, the test-retest reliability of isometric force in patients with knee osteoarthritis (OA). Methods. Mean isometric muscle strength data collected for 113 patients with knee OA were compared with published normative data for 131 asymptomatic subjects. Results. Patients with knee OA, ages 60 -79 years, could attain only 40 -53% of the knee extensor force and 35-46% of the knee flexor force generated by their age-and sex-matched peers. One-week test-retest intraclass correlations ranged from 0.79 to 0.95. Random measurement error demonstrated a favorable "signal-to-noise" ratio. Conclusion. The similar decrease in knee extensor and knee flexor strength demonstrated by patients with knee OA compared with their age-and sex-matched asymptomatic peers suggests that strategies should be directed at both muscle groups to optimally limit joint damage. Isometric muscle force measurement can be a useful assessment tool for clinicians. KEY WORD. Knee osteoarthritis isometric force reliability.

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Section: Resultsmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Isometric muscle force measurement for clinicians treating patients with osteoarthritis of the knee

Fransen¹,

Crosbie²,

Edmonds³

2003

Arthritis & Rheumatism

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“…At this stage, cartilage is even more prone to wearing. Besides degenerative changes in cartilage, the underlying bone undergoes a remodeling process that leads to a sclerosis of the subchondral bone (Radin, 1976). The developing OA increases pain, restricts exercise and limits physical capability.…”

Section: Introductionmentioning

confidence: 99%

Comparison of novel clinically applicable methodology for sensitive diagnostics of cartilage degeneration

Kiviranta

Töyräs²,

Nieminen³

et al. 2007

eCM

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In order efficiently to target therapies intending to stop or reverse degenerative processes of articular cartilage, it would be crucial to diagnose osteoarthritis (OA) earlier and more sensitively than is possible with the existing clinical methods. Unfortunately, current clinical methods for OA diagnostics are insensitive for detecting the early degenerative changes, e.g., arising from collagen network damage or proteoglycan depletion. We have recently investigated several novel quantitative biophysical methods, including ultrasound indentation, quantitative ultrasound techniques and magnetic resonance imaging, for diagnosing the degenerative changes of articular cartilage, typical for OA. In this study, the combined results of these novel diagnostic methods were compared with histological (Mankin score, MS), compositional (proteoglycan, collagen and water content) and mechanical (dynamic and equilibrium moduli) reference measurements of the same bovine cartilage samples. Receiver operating characteristics (ROC) analysis was conducted to judge the diagnostic performance of each technique. Indentation and ultrasound techniques provided the most sensitive measures to differentiate samples of intact appearance (MS= 0) from early (13) degeneration. Furthermore, these techniques were good predictors of tissue composition and mechanical properties. The specificity and sensitivity analyses revealed that the mechano-acoustic methods, when further developed for in vivo use, may provide more sensitive probes for OA diagnostics than the prevailing qualitative X-ray and arthroscopic techniques. Noninvasive quantitative MRI measurements showed slightly lower diagnostic performance than mechano-acoustic techniques. The compared methods could possibly also be used for the quantitative monitoring of success of cartilage repair.

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“…Medially localised cartilage lesions, on the other hand, were situated in a transitional region between moderate and slight subchondral mineralisation; they may be caused by infrequent stress peaks and by shear stress in the articular cartilage, the very medial part of the Joint being deprived of mechanical Stimulation for much of the time. These lesions It is widely accepted that mechanical factors play an important part in the initiation and progression of osteoarthrosis in general and chondromalacia of the patella in particular [11,25]. Nevertheless, the exact nature of the mechanism leading to Joint damage, and the exact localisation of the initial changes in cartilage degeneration are still a matter of discussion and disagreement [17].…”

Section: T Naidichmentioning

confidence: 99%

Cartilage degeneration in the human patellae and its relationship to the mineralisation of the underlying bone: A key to the understanding of chondromalacia patellae and femoropatellar arthrosis?

Eckstein¹,

Putz²,

Müller‐Gerbl³

et al. 1993

Surg Radiol Anat

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Mechanical determinants of osteoarthrosis

Cited by 291 publications

References 44 publications

Isometric muscle force measurement for clinicians treating patients with osteoarthritis of the knee

Isometric muscle force measurement for clinicians treating patients with osteoarthritis of the knee

Comparison of novel clinically applicable methodology for sensitive diagnostics of cartilage degeneration

Cartilage degeneration in the human patellae and its relationship to the mineralisation of the underlying bone: A key to the understanding of chondromalacia patellae and femoropatellar arthrosis?

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