Mechanical, corrosion, and wear properties of biomedical Ti–Zr–Nb–Ta–Mo high entropy alloys

Hua, Nengbin; Wang, Wenjie; Wang, Qianting; Ye, Youxiong; Lin, Sihan; Zhang, Lei; Guo, Qiaohang; Brechtl, Jamieson; Liaw, Peter K.

doi:10.1016/j.jallcom.2020.157997

Cited by 171 publications

(49 citation statements)

References 62 publications

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“…An evaluation of osseointegration using similar bone morphometrical parameters as in this study has been previously performed [ 49 ]. These results support those of material development of Ti alloys to which Zr, Nb, and Ta have been added [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ].…”

Section: Resultssupporting

confidence: 84%

“…The adverse effects of metal ions include the cytotoxicity of trace amounts of vanadium (V) and aluminum (Al) ions in Ti–6Al–4V alloy and the allergy-related characteristics of nickel (Ni) ions [ 2 , 3 , 4 ]. Recently, many types of Ti alloy containing noncytotoxic elements such as zirconium (Zr), niobium (Nb), tantalum (Ta), and molybdenum (Mo) have been developed for various medical applications [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. Ti–15Zr–4Nb–(0 to 4) Ta alloy, which is an alpha (α)–beta (β)-type alloy, has been developed in Japan as a highly biocompatible alloy [ 17 ], and it is standardized in JIS T 7401-4 [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Biological Safety Evaluation and Surface Modification of Biocompatible Ti–15Zr–4Nb Alloy

Okazaki

Katsuda

2021

Materials

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We performed biological safety evaluation tests of three Ti–Zr alloys under accelerated extraction condition. We also conducted histopathological analysis of long-term implantation of pure V, Al, Ni, Zr, Nb, and Ta metals as well as Ni–Ti and high-V-containing Ti–15V–3Al–3Sn alloys in rats. The effect of the dental implant (screw) shape on morphometrical parameters was investigated using rabbits. Moreover, we examined the maximum pullout properties of grit-blasted Ti–Zr alloys after their implantation in rabbits. The biological safety evaluation tests of three Ti–Zr alloys (Ti–15Zr–4Nb, Ti–15Zr–4Nb–1Ta, and Ti–15Zr–4Nb–4Ta) showed no adverse (negative) effects of either normal or accelerated extraction. No bone was formed around the pure V and Ni implants. The Al, Zr, Nb, and Ni–Ti implants were surrounded by new bone. The new bone formed around Ti–Ni and high-V-containing Ti alloys tended to be thinner than that formed around Ti–Zr and Ti–6Al–4V alloys. The rate of bone formation on the threaded portion in the Ti–15Zr–4Nb–4Ta dental implant was the same as that on a smooth surface. The maximum pullout loads of the grit- and shot-blasted Ti–Zr alloys increased linearly with implantation period in rabbits. The pullout load of grit-blasted Ti–Zr alloy rods was higher than that of shot-blasted ones. The surface roughness (Ra) and area ratio of residual Al2O3 particles of the Ti–15Zr–4Nb alloy surface grit-blasted with Al2O3 particles were the same as those of the grit-blasted Alloclassic stem surface. It was clarified that the grit-blasted Ti–15Zr–4Nb alloy could be used for artificial hip joint stems.

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Section: Resultssupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Biological Safety Evaluation and Surface Modification of Biocompatible Ti–15Zr–4Nb Alloy

Okazaki

Katsuda

2021

Materials

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“…On the one hand, during the author's research into different metallic alloys for biomedical purposes (Ti-based alloys and modified ones, CoCr alloys, etc. ), as reported in [33][34][35] and considering the outcomes of such investigations, the compositions proposed in this manuscript are those reported above. On the other hand, recent developments in research on metallic biomaterials and the requirements for Ti alloy biomaterials (high biocompatibility, no adverse effects on human tissue, high corrosion resistance in biological fluids, high mechanical strength, fatigue strength, low elasticity, low density, good wear resistance) were taken into account; based on these developments and requirements, the following two element systems were selected for the alloys investigated in this paper: Ti-Nb-Zr-Ta and Ti-Nb-Zr-Fe.…”

mentioning

confidence: 84%

Investigations into Ti-Based Metallic Alloys for Biomedical Purposes

Peter

2021

Metals

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In the present research paper, two systems based on Ti-Nb-Zr-Ta and Ti-Nb-Zr–Fe, containing non-toxic elements, are considered and investigated. The first aim of the paper is to enlarge up-to-date developed β-type Ti alloys, analyzing three different compositions, Ti-10Nb-10Zr-5Ta, Ti-20Nb-20Zr-4Ta and Ti-29.3Nb-13.6Zr-1.9Fe, in order to assess their further employment in biomedical applications. To achieve this, structural, microstructural, compositional and mechanical investigations were performed as part of this study. Based on the results obtained, the alloy with the highest Nb content seems to be the most appropriate candidate for advanced biomedical applications and, in particular, for bone substitution.

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“…Variants of the TiZrNbTaMo system were also studied by Hua et al [47] with a molar ratio of 0.5, 1, 1.5, and 2 for the Ti concentration. These high-entropy alloys showed a dendritic structure with two BCC solid solution phases.…”

Section: Comparison Of Mechanical Properties For Bone Implantsmentioning

confidence: 99%

An Overview of High-Entropy Alloys as Biomaterials

Castro

Rocha

Baptista

et al. 2021

Metals

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High-entropy alloys (HEAs) have been around since 2004. The breakthroughs in this field led to several potential applications of these alloys as refractory, structural, functional, and biomedical materials. In this work, a short overview on the concept of high-entropy alloys is provided, as well as the theoretical design approach. The special focus of this review concerns one novel class of these alloys: biomedical high-entropy alloys. Here, a literature review on the potential high-entropy alloys for biomedical applications is presented. The characteristics that are required for these alloys to be used in biomedical-oriented applications, namely their mechanical and biocompatibility properties, are discussed and compared to commercially available Ti6Al4V. Different processing routes are also discussed.

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Mechanical, corrosion, and wear properties of biomedical Ti–Zr–Nb–Ta–Mo high entropy alloys

Cited by 171 publications

References 62 publications

Biological Safety Evaluation and Surface Modification of Biocompatible Ti–15Zr–4Nb Alloy

Biological Safety Evaluation and Surface Modification of Biocompatible Ti–15Zr–4Nb Alloy

Investigations into Ti-Based Metallic Alloys for Biomedical Purposes

An Overview of High-Entropy Alloys as Biomaterials

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