Mechanical, corrosion, and biocompatibility properties of Mg-Zr-Sr-Sc alloys for biodegradable implant applications

Munir, Khurram; Lin, Jixing; Wen, Cuie; Wright, Paul; Li, Yuncang

doi:10.1016/j.actbio.2019.12.001

Cited by 105 publications

(93 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Materials based on iron (Fe), zinc (Zn), and magnesium (Mg) have been widely investigated as potential BMs for orthopedic applications [ 15 , 22 , 31 , 37 , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] ]. The microstructure of Zn alloys mainly contains a matrix phase (α-Zn) and second phases called intermetallic phases, which are generally hard and brittle.…”

Section: Introductionmentioning

confidence: 99%

Recent research and progress of biodegradable zinc alloys and composites for biomedical applications: Biomechanical and biocorrosion perspectives

Kabir

Munir

Wen

et al. 2021

Bioactive Materials

Self Cite

209

143

View full text Add to dashboard Cite

Biodegradable metals (BMs) gradually degrade in vivo by releasing corrosion products once exposed to the physiological environment in the body. Complete dissolution of biodegradable implants assists tissue healing, with no implant residues in the surrounding tissues. In recent years, three classes of BMs have been extensively investigated, including magnesium (Mg)-based, iron (Fe)-based, and zinc (Zn)-based BMs. Among these three BMs, Mg-based materials have undergone the most clinical trials. However, Mg-based BMs generally exhibit faster degradation rates, which may not match the healing periods for bone tissue, whereas Fe-based BMs exhibit slower and less complete in vivo degradation. Zn-based BMs are now considered a new class of BMs due to their intermediate degradation rates, which fall between those of Mg-based BMs and Fe-based BMs, thus requiring extensive research to validate their suitability for biomedical applications. In the present study, recent research and development on Zn-based BMs are reviewed in conjunction with discussion of their advantages and limitations in relation to existing BMs. The underlying roles of alloy composition, microstructure, and processing technique on the mechanical and corrosion properties of Zn-based BMs are also discussed.

show abstract

Section: Introductionmentioning

confidence: 99%

Recent research and progress of biodegradable zinc alloys and composites for biomedical applications: Biomechanical and biocorrosion perspectives

Kabir

Munir

Wen

et al. 2021

Bioactive Materials

Self Cite

209

143

View full text Add to dashboard Cite

show abstract

“…Therefore, the strict usage of biocompatible powders should be the main attention. The information gathered from the biodegradable bulk material design can help with the primary design of powder composition [89,[110][111][112]. For the enhancement of biocompatibility and mechanical integrity of bulk magnesium alloys during biodegradation, surface biofunctionalization has been carried out [113].…”

Section: Biocompatibilitymentioning

confidence: 99%

A review of additive manufacturing of Mg-based alloys and composite implants

Zamani

Ghazanfari

Erabi

et al. 2021

jcc

View full text Add to dashboard Cite

Magnesium based materials are considered promising biodegradable metals for orthopedic bone implant applications as they exhibit similar density and elastic modulus to that of bone, biodegradability, and excellent osteogenic properties. The use of Mg based biomaterials eliminates the limitations of currently used implant materials such as stress shielding and the need for the second surgery. Recently, the development of Mg-based implants has attracted significant attention. Additive manufacturing is one of the effective techniques to develop Mg based implants. Additive manufacturing which could be named 3D printing is a transformative and rapid method of producing industrial parts with in the acceptable dimensional range. Therefore, recent investigations have tried to apply this method for the development of Mg-based implants. This state-of-the-art review focuses on the additive manufacturing of Mg biodegradable materials and their in-vitro corrosion and degradation, and mechanical properties. The future directions to develop Mg biodegradable materials are reported through summarization of current achievements.

show abstract

“…First, the mechanical properties of magnesium alloys have not yet met the performance requirements for implant materials, and their fast resorption can lead to mechanical instability before completion of bone healing. [13,24,25] Second, the degradation rates of magnesium alloys are too fast, especially in an aggressive chloride medium like human bodily fluids, and the degradation products are likely to cause problems such as tissue inflammation. [26] Finally, magnesium alloys do not corrode uniformly, which may cause premature failure of implant materials.…”

Section: Introductionmentioning

confidence: 99%

Progress in Research on Biodegradable Magnesium Alloys: A Review

Wen

et al. 2020

Adv Eng Mater

View full text Add to dashboard Cite

Magnesium alloys have great potential as biodegradable materials and have attracted much attention in recent years. Much effort has been expended to improve the properties of biodegradable alloys. Herein, various methods for improving the mechanical properties and biocorrosion resistance of magnesium alloys are discussed in detail, including alloying, thermal processing, and surface modification. The mechanisms by which the mechanical properties of alloys are modified are described, including grain refinement strengthening, solid solution strengthening, dislocation strengthening, and precipitation strengthening. On the basis of previous studies, the mechanisms underlying modifications to the biocorrosion resistance of magnesium alloys are summarized as grain refinement, grain growth, the formation of a passivation film, reduction in cathode-anode potential difference, second-phase barrier function, and texture formation. Finally, the remaining problems are summarized and directions for future research are indicated.

show abstract

Mechanical, corrosion, and biocompatibility properties of Mg-Zr-Sr-Sc alloys for biodegradable implant applications

Cited by 105 publications

References 71 publications

Recent research and progress of biodegradable zinc alloys and composites for biomedical applications: Biomechanical and biocorrosion perspectives

Recent research and progress of biodegradable zinc alloys and composites for biomedical applications: Biomechanical and biocorrosion perspectives

A review of additive manufacturing of Mg-based alloys and composite implants

Progress in Research on Biodegradable Magnesium Alloys: A Review

Contact Info

Product

Resources

About