Mechanical Behaviour Evaluation of Porous Scaffold for Tissue-Engineering Applications Using Finite Element Analysis

Kakarla, Akesh Babu; Kong, Ing; Nukala, Satya Guha; Kong, Win

doi:10.3390/jcs6020046

Cited by 15 publications

(7 citation statements)

References 58 publications

(73 reference statements)

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“…The authors concluded that both cross-linking time and volume of the cross-linker were important in the modulation of the mechanical properties of the scaffolds. Also using alginate, Kakarla et al (2022) investigated the maximum stress regions and observed that the stress regions were at the soft zones near the pore area. Compared to experimental results, the stress-strain curves were similar, with a maximum strength obtained at 2.8 MPa for the experimental results and 2.7 MPa for the FE analysis.…”

Section: Finite Element Analysismentioning

confidence: 99%

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

Teixeira

Martins

2023

Front. Bioeng. Biotechnol.

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Female breast cancer was the most prevalent cancer worldwide in 2020, according to the Global Cancer Observatory. As a prophylactic measure or as a treatment, mastectomy and lumpectomy are often performed at women. Following these surgeries, women normally do a breast reconstruction to minimize the impact on their physical appearance and, hence, on their mental health, associated with self-image issues. Nowadays, breast reconstruction is based on autologous tissues or implants, which both have disadvantages, such as volume loss over time or capsular contracture, respectively. Tissue engineering and regenerative medicine can bring better solutions and overcome these current limitations. Even though more knowledge needs to be acquired, the combination of biomaterial scaffolds and autologous cells appears to be a promising approach for breast reconstruction. With the growth and improvement of additive manufacturing, three dimensional (3D) printing has been demonstrating a lot of potential to produce complex scaffolds with high resolution. Natural and synthetic materials have been studied in this context and seeded mainly with adipose derived stem cells (ADSCs) since they have a high capability of differentiation. The scaffold must mimic the environment of the extracellular matrix (ECM) of the native tissue, being a structural support for cells to adhere, proliferate and migrate. Hydrogels (e.g., gelatin, alginate, collagen, and fibrin) have been a biomaterial widely studied for this purpose since their matrix resembles the natural ECM of the native tissues. A powerful tool that can be used in parallel with experimental techniques is finite element (FE) modeling, which can aid the measurement of mechanical properties of either breast tissues or scaffolds. FE models may help in the simulation of the whole breast or scaffold under different conditions, predicting what might happen in real life. Therefore, this review gives an overall summary concerning the human breast, specifically its mechanical properties using experimental and FE analysis, and the tissue engineering approaches to regenerate this particular tissue, along with FE models.

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Section: Finite Element Analysismentioning

confidence: 99%

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

Teixeira

Martins

2023

Front. Bioeng. Biotechnol.

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“…These microstructures act as well-designed reinforcements that mirror the natural tissue’s ability to effectively distribute forces and endure stresses. The strategic arrangement of interwoven struts and lattice formations ensures that bioprinted constructs replicate the biomechanical integrity of native tissues, establishing a foundation for enhanced durability, resilience, and overall stability . This biomechanical resemblance bridges the elegance of natural architecture with the practical demands of functional tissue engineering.…”

Section: Role Of Trabecular Microarchitecture In Scaffold Bioactivitymentioning

confidence: 99%

Prioritizing Biomaterial Driven Clinical Bioactivity Over Designing Intricacy during Bioprinting of Trabecular Microarchitecture: A Clinician’s Perspective

Kumar Shetty,

Sundar Santhanakrishnan,

Padurao

et al. 2024

ACS Omega

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Bone tissue engineering has witnessed a historical shift from three perspectives. From a biomaterial perspective, materials have now become smarter and dynamic; from a bioengineering perspective the bioprinting techniques have now advanced to 4D bioprinting; and from a clinical perspective scaffold bioactivity has progressed toward enhanced osteoinductive scaffolds driven by intricate biomechanical, biophysical, biochemical, and biological cues. Though all of these advancements are indicative of improvised scaffold engineering, a pivotal question regarding the critical role and need of designing and replicating the intricacies of trabecular microarchitecture for enhanced, clinically appreciable osteoangiogenicity needs to be answered. This review hence critically evaluates the rationale and the need of investing substantial effort into designing complex microarchitectures amidst the era of "smart biomaterials" and dynamic 4D bioprinting aimed toward enhancing clinically appreciable bioactivity. The article explores the concept of integrating intricate designs into a scaffold microarchitecture to bolster bioactivity and the practical challenges encountered in 3D bioprinting of complex designs and meticulously examines the pivotal role of biomaterials in scaffold bioactivity, proposing a comprehensive approach to bioprinting geared toward achieving clinical bioactivity and striking a judicious balance between design intricacy and functional outcomes in bone bioprinting.

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“…FEA is widely used to simulate the mechanical behaviour of hydrogels, including their deformation, stress distribution, and responses to external forces [50,51]. It helps us understand how hydrogels will behave in different loading conditions and assists in designing hydrogels with specific mechanical properties for applications such as tissue engineering, drug delivery, and medical devices.…”

Section: Numerical Simulationsmentioning

confidence: 99%

Exploring the Potential of Artificial Intelligence for Hydrogel Development—A Short Review

Negut,

Bita

2023

Gels

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AI and ML have emerged as transformative tools in various scientific domains, including hydrogel design. This work explores the integration of AI and ML techniques in the realm of hydrogel development, highlighting their significance in enhancing the design, characterisation, and optimisation of hydrogels for diverse applications. We introduced the concept of AI train hydrogel design, underscoring its potential to decode intricate relationships between hydrogel compositions, structures, and properties from complex data sets. In this work, we outlined classical physical and chemical techniques in hydrogel design, setting the stage for AI/ML advancements. These methods provide a foundational understanding for the subsequent AI-driven innovations. Numerical and analytical methods empowered by AI/ML were also included. These computational tools enable predictive simulations of hydrogel behaviour under varying conditions, aiding in property customisation. We also emphasised AI’s impact, elucidating its role in rapid material discovery, precise property predictions, and optimal design. ML techniques like neural networks and support vector machines that expedite pattern recognition and predictive modelling using vast datasets, advancing hydrogel formulation discovery are also presented. AI and ML’s have a transformative influence on hydrogel design. AI and ML have revolutionised hydrogel design by expediting material discovery, optimising properties, reducing costs, and enabling precise customisation. These technologies have the potential to address pressing healthcare and biomedical challenges, offering innovative solutions for drug delivery, tissue engineering, wound healing, and more. By harmonising computational insights with classical techniques, researchers can unlock unprecedented hydrogel potentials, tailoring solutions for diverse applications.

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Mechanical Behaviour Evaluation of Porous Scaffold for Tissue-Engineering Applications Using Finite Element Analysis

Cited by 15 publications

References 58 publications

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

A review of bioengineering techniques applied to breast tissue: Mechanical properties, tissue engineering and finite element analysis

Prioritizing Biomaterial Driven Clinical Bioactivity Over Designing Intricacy during Bioprinting of Trabecular Microarchitecture: A Clinician’s Perspective

Exploring the Potential of Artificial Intelligence for Hydrogel Development—A Short Review

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