Mechanical behavior of cold‐water fish gelatin gels crosslinked with 1,4‐butanediol diglycidyl ether

Abstract

In this work, chemical crosslinking with 1,4‐butanediol diglycidyl ether (BDDGE) is used as strategy to enhance mechanical performance of fish gelatin (FG) gels in order to meet the properties' range of mammalian gelatin physical gels. Joint analysis of free amino groups, swelling ratio, and total soluble material indicates that crosslinking degree increases with increasing FG concentration and it is favored by a 0.2 BDDGE/FG ratio. Increasing crosslinking degree enhances gel indentation strength and shear modulus (μ) while decreases fracture toughness (GIC). Measured μ and GIC values lies within the range exhibited by mammalian gelatin physical gels, but the relationship between these parameters is opposite. This is due to the different fracture mechanisms occurring in chemically crosslinked and physical gels.

Characterization of gelatin hydrogels derived from different animal sources

“…Collagen can be either processed by acidic or lime-curing treatment to obtain type A and type B gelatin, respectively. When crosslinked, gelatin forms hydrogels that gained success as scaffolds for regenerative medicine [2], wound dressings [3] and drug delivery applications [4], thanks to its availability, intrinsic presence of cell-adhesive motifs (i.e., RGD sequence), in vivo degradability, and versatility [5]. Different fabrication technologies can be selected to produce gelatin hydrogels (e.g., freeze-drying, particulate leaching, emulsion, 3D printing, electrospinning)…”

Swim bladder-derived biomaterials: structures, compositions, properties, modifications, and biomedical applications

“…BDDGE is water-soluble and can be used as a bifunctional crosslinker to bind amino acids. It is widely used for the crosslinking of HA and gelatin [ 122 ]. Zeeman et al studied its mechanism by crosslinking sheep skin with BDDGE (Fig.…”

Water-Insoluble, Thermostable, Crosslinked Gelatin Matrix for Soft Tissue Implant Development

“…In our previous works, we also found that the use of butanediol diglycidyl ether (BDDE) is safe, as the biocompatibility and cell viability did not change with the use of this material [19]. BDDE was also used to crosslink fish-derived gelatin, and the mechanical properties were examined but not as a biologically applicable material [20]. It had also been discovered earlier that BDDE is suitable to crosslink primary amino groups, and it has been used to modify collagen from sheep [21].…”